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Vps37a VPS37A subunit of ESCRT-I [ Rattus norvegicus (Norway rat) ]

Gene ID: 290775, updated on 17-Aug-2024

Summary

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Official Symbol
Vps37aprovided by RGD
Official Full Name
VPS37A subunit of ESCRT-Iprovided by RGD
Primary source
RGD:1560016
See related
EnsemblRapid:ENSRNOG00000012001 AllianceGenome:RGD:1560016
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in protein targeting to membrane; protein targeting to vacuole; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be located in centrosome; cytosol; and nucleoplasm. Predicted to be part of ESCRT I complex. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 53. Orthologous to human VPS37A (VPS37A subunit of ESCRT-I). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 113.1), Thymus (RPKM 107.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Vps37a in Genome Data Viewer
Location:
16q12.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (58434802..58478777, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (51736170..51775384, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (54860811..54899410, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene a disintegrin and metallopeptidase domain 25 Neighboring gene ADAM metallopeptidase domain 24 Neighboring gene myotubularin related protein 7 Neighboring gene CCR4-NOT transcription complex, subunit 7 Neighboring gene zinc finger DHHC-type palmitoyltransferase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Distinct functions of human MVB12A and MVB12B in the ESCRT-I dependent on their posttranslational modifications. Tsunematsu T, et al. Biochem Biophys Res Commun, 2010 Aug 20. PMID 20654576
  2. UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting. Stefani F, et al. Curr Biol, 2011 Jul 26. PMID 21757351
  3. Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding. Morita E, et al. Cell Host Microbe, 2007 Jul 12. PMID 18005716, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC116266

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of ESCRT I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESCRT I complex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
vacuolar protein sorting-associated protein 37A
Names
VPS37A, ESCRT-I subunit
vacuolar protein sorting 37 homolog A
vacuolar protein sorting 37A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024867.1 → NP_001020038.1  vacuolar protein sorting-associated protein 37A

    See identical proteins and their annotated locations for NP_001020038.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098069
    UniProtKB/TrEMBL
    A6JPV3, F7FHB3, Q4V794
    Related
    ENSRNOP00000016321.5, ENSRNOT00000016321.7
    Conserved Domains (1) summary
    pfam07200
    Location:236 → 381
    Mod_r; Modifier of rudimentary (Mod(r)) protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    58434802..58478777 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275236.1 → XP_063131306.1  vacuolar protein sorting-associated protein 37A isoform X2

    UniProtKB/TrEMBL
    A0A8I6GCD4

  2. XM_063275235.1 → XP_063131305.1  vacuolar protein sorting-associated protein 37A isoform X1

    UniProtKB/TrEMBL
    A6JPV3, F7FHB3, Q4V794

  3. XM_008771289.4 → XP_008769511.1  vacuolar protein sorting-associated protein 37A isoform X2

    UniProtKB/TrEMBL
    A0A8I6GCD4
    Related
    ENSRNOP00000085018.1, ENSRNOT00000093996.2
    Conserved Domains (1) summary
    pfam07200
    Location:236 → 358
    Mod_r; Modifier of rudimentary (Mod(r)) protein

  4. XM_039094386.2 → XP_038950314.1  vacuolar protein sorting-associated protein 37A isoform X3

    UniProtKB/TrEMBL
    A6JPV5
    Conserved Domains (1) summary
    pfam07200
    Location:90 → 235
    Mod_r; Modifier of rudimentary (Mod(r)) protein

RNA

  1. XR_596484.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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