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Adam9 ADAM metallopeptidase domain 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 290834, updated on 2-Nov-2024

Summary

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Official Symbol
Adam9provided by RGD
Official Full Name
ADAM metallopeptidase domain 9provided by RGD
Primary source
RGD:621473
See related
EnsemblRapid:ENSRNOG00000017231 AllianceGenome:RGD:621473
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MDC9
Summary
Predicted to enable several functions, including SH3 domain binding activity; metalloendopeptidase activity involved in amyloid precursor protein catabolic process; and protein kinase C binding activity. Involved in response to antineoplastic agent and response to laminar fluid shear stress. Located in basolateral plasma membrane and cell surface. Biomarker of Alzheimer's disease and status epilepticus. Human ortholog(s) of this gene implicated in cone-rod dystrophy 9. Orthologous to human ADAM9 (ADAM metallopeptidase domain 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 255.8), Lung (RPKM 241.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Adam9 in Genome Data Viewer
Location:
16q12.4
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (73725186..73804284)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (67022538..67101647)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (71810377..71887926)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene HtrA serine peptidase 4 Neighboring gene TM2 domain containing 2 Neighboring gene U6 spliceosomal RNA Neighboring gene ADAM metallopeptidase domain 32 Neighboring gene ADAM metallopeptidase domain 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification, cellular distribution and potential function of the metalloprotease-disintegrin MDC9 in the kidney. Mahimkar RM, et al. J Am Soc Nephrol, 2000 Apr. PMID 10752518
  2. Low blood flow after angioplasty augments mechanisms of restenosis: inward vessel remodeling, cell migration, and activity of genes regulating migration. Ward MR, et al. Arterioscler Thromb Vasc Biol, 2001 Feb. PMID 11156854
  3. ADAM9 expression in pancreatic cancer is associated with tumour type and is a prognostic factor in ductal adenocarcinoma. Grützmann R, et al. Br J Cancer, 2004 Mar 8. PMID 14997207, Free PMC Article
  4. Expression of ADAM9 in CIN3 lesions and squamous cell carcinomas of the cervix. Zubel A, et al. Gynecol Oncol, 2009 Aug. PMID 19473694
  5. ADAM9 is involved in pathological retinal neovascularization. Guaiquil V, et al. Mol Cell Biol, 2009 May. PMID 19273593, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables collagen binding ISO
Inferred from Sequence Orthology
more info
  
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables integrin binding ISO
Inferred from Sequence Orthology
more info
  
enables laminin binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
enables metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in amyloid precursor protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in cell-cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
  
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
involved_in keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in membrane protein ectodomain proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within membrane protein intracellular domain proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in monocyte activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of keratinocyte migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of macrophage fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in response to antineoplastic agent IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
involved_in response to glucocorticoid ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
  
involved_in response to laminar fluid shear stress IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to manganese ion ISO
Inferred from Sequence Orthology
more info
  
involved_in response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
  
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 9
Names
a disintegrin and metallopeptidase domain 9 (meltrin gamma)
a disintegrin and metalloproteinase domain 9 (meltrin gamma)
meltrin gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014772.2 → NP_001014772.2  disintegrin and metalloproteinase domain-containing protein 9 precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    E9PTA4, Q58GH6
    Related
    ENSRNOP00000102349.1, ENSRNOT00000168882.1
    Conserved Domains (6) summary
    smart00050
    Location:423 → 498
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:500 → 636
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:212 → 406
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:44 → 163
    Pep_M12B_propep; Reprolysin family propeptide
    pfam07974
    Location:650 → 673
    EGF_2; EGF-like domain
    pfam15240
    Location:732 → 802
    Pro-rich; Proline-rich

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    73725186..73804284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275248.1 → XP_063131318.1  disintegrin and metalloproteinase domain-containing protein 9 isoform X1

  2. XM_039094403.2 → XP_038950331.1  disintegrin and metalloproteinase domain-containing protein 9 isoform X2

    UniProtKB/TrEMBL
    Q58GH6
    Related
    ENSRNOP00000089910.2, ENSRNOT00000120151.2
    Conserved Domains (6) summary
    smart00050
    Location:423 → 498
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:500 → 636
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:212 → 406
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:44 → 163
    Pep_M12B_propep; Reprolysin family propeptide
    pfam06346
    Location:747 → 793
    Drf_FH1; Formin Homology Region 1
    pfam07974
    Location:650 → 673
    EGF_2; EGF-like domain

  3. XM_063275249.1 → XP_063131319.1  disintegrin and metalloproteinase domain-containing protein 9 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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