U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Aga aspartylglucosaminidase [ Rattus norvegicus (Norway rat) ]

Gene ID: 290923, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Agaprovided by RGD
Official Full Name
aspartylglucosaminidaseprovided by RGD
Primary source
RGD:1309646
See related
EnsemblRapid:ENSRNOG00000000108 AllianceGenome:RGD:1309646
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity and identical protein binding activity. Predicted to be involved in protein deglycosylation. Predicted to be located in endoplasmic reticulum and extracellular space. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in aspartylglucosaminuria and lysosomal storage disease. Orthologous to human AGA (aspartylglucosaminidase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 321.3), Lung (RPKM 293.4) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Aga in Genome Data Viewer
Location:
16p11
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (45191215..45249537, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (38504661..38516607, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (41222225..41234169, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene nei-like DNA glycosylase 3 Neighboring gene high mobility group protein B1-like Neighboring gene cytochrome b-c1 complex subunit 6, mitochondrial-like Neighboring gene U7 small nuclear RNA Neighboring gene poly(A) binding protein, cytoplasmic 1, pseudogene 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Co-localization of hydrolytic enzymes with widely disparate pH optima: implications for the regulation of lysosomal pH. Butor C, et al. J Cell Sci, 1995 Jun. PMID 7673341
  2. Comparison of liver glycosylasparaginases from six vertebrates. Tollersrud OK, et al. Biochem J, 1992 Mar 15. PMID 1554372, Free PMC Article
  3. Ser72Pro active-site disease mutation in human lysosomal aspartylglucosaminidase: abnormal intracellular processing and evidence for extracellular activation. Peltola M, et al. Hum Mol Genet, 1996 Jun. PMID 8776587
  4. Molecular cloning, chromosomal assignment, and expression of the mouse aspartylglucosaminidase gene. Tenhunen K, et al. Genomics, 1995 Nov 20. PMID 8586423
  5. Purification and characterization of rat liver glycosylasparaginase. Tollersrud OK, et al. Biochem J, 1989 May 15. PMID 2775174, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC112709

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity IEA
Inferred from Electronic Annotation
more info
  
enables N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein deglycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein deglycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein deglycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase
Names
N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase
glycosylasparaginase
NP_001026811.1
XP_006253173.1
XP_038950351.1
XP_038950352.1
XP_063131333.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031641.1 → NP_001026811.1  N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase precursor

    See identical proteins and their annotated locations for NP_001026811.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098718
    UniProtKB/Swiss-Prot
    P30919, Q4G065
    UniProtKB/TrEMBL
    A0A8I5ZKU5, A6JPI4
    Related
    ENSRNOP00000000120.3, ENSRNOT00000000120.5
    Conserved Domains (1) summary
    cd04513
    Location:29 → 331
    Glycosylasparaginase; Glycosylasparaginase and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    45191215..45249537 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275263.1 → XP_063131333.1  N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase isoform X2

    Related
    ENSRNOP00000078440.2, ENSRNOT00000116014.2

  2. XM_006253111.5 → XP_006253173.1  N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZKU5, A0A8I6AL08
    Related
    ENSRNOP00000093756.1, ENSRNOT00000107358.2
    Conserved Domains (1) summary
    cd04513
    Location:29 → 350
    Glycosylasparaginase; Glycosylasparaginase and similar proteins

  3. XM_039094423.2 → XP_038950351.1  N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase isoform X3

    UniProtKB/TrEMBL
    A6JPI5
    Conserved Domains (1) summary
    cd04513
    Location:1 → 235
    Glycosylasparaginase; Glycosylasparaginase and similar proteins

  4. XM_039094424.2 → XP_038950352.1  N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase isoform X3

    UniProtKB/TrEMBL
    A6JPI5
    Conserved Domains (1) summary
    cd04513
    Location:1 → 235
    Glycosylasparaginase; Glycosylasparaginase and similar proteins

RNA

  1. XR_010058288.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30919.2 GenPept UniProtKB/Swiss-Prot:P30919

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous