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Aopep aminopeptidase O [ Rattus norvegicus (Norway rat) ]

Gene ID: 290963, updated on 2-Nov-2024

Summary

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Official Symbol
Aopepprovided by RGD
Official Full Name
aminopeptidase Oprovided by RGD
Primary source
RGD:1309592
See related
EnsemblRapid:ENSRNOG00000017505 AllianceGenome:RGD:1309592
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Apo; Npepo; RGD1309592
Summary
Predicted to enable metalloaminopeptidase activity and zinc ion binding activity. Predicted to be involved in proteolysis. Predicted to be active in nucleolus. Human ortholog(s) of this gene implicated in dystonia 31. Orthologous to human AOPEP (aminopeptidase O (putative)). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 178.3), Heart (RPKM 176.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Aopep in Genome Data Viewer
Location:
17p14
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (1817001..2133008, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (1811281..2127316, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (507389..825062)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene patched 1 Neighboring gene uncharacterized LOC134482656 Neighboring gene small nucleolar RNA SNORA76 Neighboring gene FA complementation group C Neighboring gene microRNA 3074 Neighboring gene microRNA 24-1 Neighboring gene microRNA 27b Neighboring gene microRNA 23b Neighboring gene uncharacterized LOC134482655 Neighboring gene uncharacterized LOC134482654 Neighboring gene uncharacterized LOC102551048 Neighboring gene fructose-bisphosphatase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Aminopeptidase O contains a functional nucleolar localization signal and is implicated in vascular biology. Axton R, et al. J Cell Biochem, 2008 Mar 1. PMID 17803194
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metalloaminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
aminopeptidase O
Names
AP-O

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012346.2 → NP_001012346.2  aminopeptidase O

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/Swiss-Prot
    F1LRV1, P69527
    Related
    ENSRNOP00000107620.1, ENSRNOT00000160757.1
    Conserved Domains (2) summary
    pfam09127
    Location:709 → 821
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:244 → 640
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    1817001..2133008 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276129.1 → XP_063132199.1  aminopeptidase O isoform X3

  2. XM_063276130.1 → XP_063132200.1  aminopeptidase O isoform X4

  3. XM_063276125.1 → XP_063132195.1  aminopeptidase O isoform X1

    UniProtKB/TrEMBL
    A0A8L2QC72
    Related
    ENSRNOP00000023638.7, ENSRNOT00000023638.8

  4. XM_063276126.1 → XP_063132196.1  aminopeptidase O isoform X1

    UniProtKB/TrEMBL
    A0A8L2QC72

  5. XM_017600471.3 → XP_017455960.1  aminopeptidase O isoform X1

    UniProtKB/TrEMBL
    A0A8L2QC72
    Conserved Domains (2) summary
    pfam09127
    Location:743 → 884
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:250 → 697
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  6. XM_008771431.4 → XP_008769653.1  aminopeptidase O isoform X2

    See identical proteins and their annotated locations for XP_008769653.1

    UniProtKB/Swiss-Prot
    F1LRV1, P69527
    Conserved Domains (2) summary
    pfam09127
    Location:709 → 821
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:244 → 640
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  7. XM_008771432.4 → XP_008769654.1  aminopeptidase O isoform X2

    See identical proteins and their annotated locations for XP_008769654.1

    UniProtKB/Swiss-Prot
    F1LRV1, P69527
    Conserved Domains (2) summary
    pfam09127
    Location:709 → 821
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:244 → 640
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  8. XM_008771429.4 → XP_008769651.1  aminopeptidase O isoform X1

    See identical proteins and their annotated locations for XP_008769651.1

    UniProtKB/TrEMBL
    A0A8L2QC72
    Conserved Domains (2) summary
    pfam09127
    Location:743 → 884
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:250 → 697
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  9. XM_063276127.1 → XP_063132197.1  aminopeptidase O isoform X2

    UniProtKB/Swiss-Prot
    F1LRV1, P69527

  10. XM_017600473.3 → XP_017455962.1  aminopeptidase O isoform X2

    UniProtKB/Swiss-Prot
    F1LRV1, P69527
    Conserved Domains (2) summary
    pfam09127
    Location:709 → 821
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:244 → 640
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  11. XM_063276133.1 → XP_063132203.1  aminopeptidase O isoform X7

  12. XM_063276131.1 → XP_063132201.1  aminopeptidase O isoform X5

  13. XM_063276132.1 → XP_063132202.1  aminopeptidase O isoform X6

RNA

  1. XR_010058813.1 RNA Sequence

  2. XR_010058815.1 RNA Sequence

  3. XR_010058814.1 RNA Sequence

  4. XR_010058816.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P69527.2 GenPept UniProtKB/Swiss-Prot:P69527

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