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Gadd45g growth arrest and DNA-damage-inducible, gamma [ Rattus norvegicus (Norway rat) ]

Gene ID: 291005, updated on 17-Aug-2024

Summary

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Official Symbol
Gadd45gprovided by RGD
Official Full Name
growth arrest and DNA-damage-inducible, gammaprovided by RGD
Primary source
RGD:1311796
See related
EnsemblRapid:ENSRNOG00000013090 AllianceGenome:RGD:1311796
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including positive regulation of apoptotic process; positive regulation of cold-induced thermogenesis; and positive regulation of stress-activated MAPK cascade. Predicted to act upstream of or within negative regulation of protein kinase activity and positive regulation of MAPK cascade. Predicted to be active in cytoplasm and nucleus. Biomarker of mesangial proliferative glomerulonephritis. Orthologous to human GADD45G (growth arrest and DNA damage inducible gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 128.0), Heart (RPKM 101.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
17p14
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (13528606..13530351, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (13376842..13378587, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (13391474..13393219, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482768 Neighboring gene uncharacterized LOC120097809 Neighboring gene semaphorin 4D Neighboring gene uncharacterized LOC134482683 Neighboring gene SECIS binding protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Apoptosis of glomerular mesangial cells induced by sublytic C5b-9 complexes in rats with Thy-1 nephritis is dependent on Gadd45 gamma upregulation. Qiu W, et al. Eur J Immunol, 2009 Nov. PMID 19882653
  2. Molecular cloning of rat GADD45gamma, gene induction and its role during neuronal cell death. Kojima S, et al. FEBS Lett, 1999 Mar 12. PMID 10100865
  3. The crystal structure and dimerization interface of GADD45gamma. Schrag JD, et al. Proc Natl Acad Sci U S A, 2008 May 6. PMID 18445651, Free PMC Article
  4. Gene expression profile and overexpression of apoptosis-related genes (NGFI-B and Gadd 45 gamma) in early phase of Thy-1 nephritis model. Xu JH, et al. Cell Tissue Res, 2006 Oct. PMID 16736195
  5. Sex differences in Gadd45b expression and methylation in the developing rodent amygdala. Kigar SL, et al. Brain Res, 2016 Jul 1. PMID 27086974, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MicroRNA-128-1-5p attenuates myocardial ischemia/reperfusion injury by suppressing Gadd45g-mediated apoptotic signaling.
    Title: MicroRNA-128-1-5p attenuates myocardial ischemia/reperfusion injury by suppressing Gadd45g-mediated apoptotic signaling.
  2. Report of sex differences in the expression of growth arrest and DNA damage inducible factor beta (Gadd45b), but not family members alpha (a) or gamma (g), in the neonatal and juvenile rodent amygdala
    Title: Sex differences in Gadd45b expression and methylation in the developing rodent amygdala.
  3. Gadd45 gamma gene expression is involved in regulating glomerular mesangial cell apoptosis mediated by sublytic C5b-9 in Thy-1 nephritis
    Title: Apoptosis of glomerular mesangial cells induced by sublytic C5b-9 complexes in rats with Thy-1 nephritis is dependent on Gadd45 gamma upregulation.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
growth arrest and DNA damage-inducible protein GADD45 gamma
Names
GADD45gamma
growth arrest and DNA damage inducible
growth arrest and DNA-damage-inducible 45 gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077640.2 → NP_001071108.1  growth arrest and DNA damage-inducible protein GADD45 gamma

    See identical proteins and their annotated locations for NP_001071108.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/Swiss-Prot
    Q9WTQ7
    UniProtKB/TrEMBL
    B5DEF0
    Related
    ENSRNOP00000018251.4, ENSRNOT00000018252.9
    Conserved Domains (1) summary
    pfam01248
    Location:24 → 106
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    13528606..13530351 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WTQ7.1 GenPept UniProtKB/Swiss-Prot:Q9WTQ7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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