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Ogn osteoglycin [ Rattus norvegicus (Norway rat) ]

Gene ID: 291015, updated on 28-Oct-2024

Summary

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Symbol
Ognprovided by RGD
Full Name
osteoglycinprovided by RGD
Primary source
RGD:1308171
See related
EnsemblRapid:ENSRNOG00000029792 AllianceGenome:RGD:1308171
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable growth factor activity. Involved in negative regulation of smooth muscle cell proliferation. Predicted to be located in endoplasmic reticulum. Predicted to be active in extracellular matrix. Orthologous to human OGN (osteoglycin). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Heart (RPKM 851.8), Lung (RPKM 538.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ogn in Genome Data Viewer
Location:
17p14
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (15238500..15259167, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (15032069..15052626, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (14607442..14628274, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene isoleucyl-tRNA synthetase 1 Neighboring gene small nucleolar RNA SNORA84 Neighboring gene nucleolar protein 8 Neighboring gene centromere protein P Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene osteomodulin Neighboring gene asporin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mimecan is involved in aortic hypertrophy induced by sinoaortic denervation in rats. Gu XS, et al. Mol Cell Biochem, 2011 Jun. PMID 21519924
  2. Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass. Petretto E, et al. Nat Genet, 2008 May. PMID 18443592, Free PMC Article
  3. Osteoglycin knockdown promotes vascular smooth muscle cell proliferation and migration in aortic dissection via the VEGF/VEGFR2 axis. Wang Z, et al. Mol Med Rep, 2021 Jan. PMID 33215216
  4. Osteoglycin post-transcriptional regulation by miR-155 induces cellular architecture changes in H9c2 cardiomyoblasts. de Oliveira G, et al. Gene, 2018 Nov 15. PMID 29990505
  5. Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset. Chiasserini D, et al. J Proteomics, 2014 Jun 25. PMID 24769233

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Osteoglycin knockdown promotes vascular smooth muscle cell proliferation and migration in aortic dissection via the VEGF/VEGFR2 axis.
    Title: Osteoglycin knockdown promotes vascular smooth muscle cell proliferation and migration in aortic dissection via the VEGF/VEGFR2 axis.
  2. Study reveals that Ogn is post-transcriptionally regulated by miR-155 in the maintenance of the cardiac cell morphology in physiological and pathological conditions.
    Title: Osteoglycin post-transcriptional regulation by miR-155 induces cellular architecture changes in H9c2 cardiomyoblasts.
  3. concluded that down-regulation of mimecan was involved in aortic hypertrophy induced by sinoaortic denervation in rats
    Title: Mimecan is involved in aortic hypertrophy induced by sinoaortic denervation in rats.
  4. These data implicate Ogn as a key regulator of LVM in rats, mice and humans, and suggest that Ogn modifies the hypertrophic response to extrinsic factors such as hypertension and aortic stenosis.
    Title: Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in articular cartilage development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in bone development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mimecan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106103.1 → NP_001099573.1  mimecan precursor

    See identical proteins and their annotated locations for NP_001099573.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473977
    UniProtKB/TrEMBL
    A6J6V8, D3ZVB7
    Related
    ENSRNOP00000020532.5, ENSRNOT00000020532.9
    Conserved Domains (2) summary
    sd00033
    Location:123 → 144
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:143 → 225
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    15238500..15259167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008771490.4 → XP_008769712.1  mimecan isoform X1

    See identical proteins and their annotated locations for XP_008769712.1

    UniProtKB/TrEMBL
    A0A1W2Q6Q0
    Related
    ENSRNOP00000110107.1, ENSRNOT00000171835.1
    Conserved Domains (4) summary
    cd00116
    Location:249 → 352
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:229 → 250
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:249 → 331
    LRR_8; Leucine rich repeat
    pfam15376
    Location:167 → 264
    DUF4603; Domain of unknown function (DUF4603)

  2. XM_063276149.1 → XP_063132219.1  mimecan isoform X1

    UniProtKB/TrEMBL
    A0A1W2Q6Q0
Nucleotide Protein Strain
Heading Accession and Version

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