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Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291057, updated on 5-Mar-2024

Summary

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Official Symbol
Eef1e1provided by RGD
Official Full Name
eukaryotic translation elongation factor 1 epsilon 1provided by RGD
Primary source
RGD:1311056
See related
Ensembl:ENSRNOG00000066344 AllianceGenome:RGD:1311056
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable translation elongation factor activity. Predicted to be involved in negative regulation of cell population proliferation; positive regulation of apoptotic process; and positive regulation of cellular senescence. Predicted to act upstream of or within cellular response to leukemia inhibitory factor; positive regulation of DNA damage response, signal transduction by p53 class mediator; and positive regulation of apoptotic signaling pathway. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Orthologous to human EEF1E1 (eukaryotic translation elongation factor 1 epsilon 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 251.4), Brain (RPKM 203.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Eef1e1 in Genome Data Viewer
Location:
17p12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (26354247..26364953)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (26148652..26159358)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (26785017..26795723)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097954 Neighboring gene solute carrier family 35 member B3 Neighboring gene DNA polymerase epsilon 3, accessory subunit, pseudogene 2 Neighboring gene uncharacterized LOC134482843 Neighboring gene putative protein CRIPAK Neighboring gene biogenesis of lysosomal organelles complex 1 subunit 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Loss of expression of the tumour suppressor gene AIMP3 predicts survival following radiotherapy in muscle-invasive bladder cancer. Gurung PM, et al. Int J Cancer, 2015 Feb 1. PMID 24917520
  2. Expression of AIMP1, 2 and 3, the scaffolds for the multi-tRNA synthetase complex, is downregulated in gastric and colorectal cancer. Kim SS, et al. Tumori, 2011 May-Jun. PMID 21789020
  3. Downregulation of lamin A by tumor suppressor AIMP3/p18 leads to a progeroid phenotype in mice. Oh YS, et al. Aging Cell, 2010 Oct. PMID 20726853
  4. miR-543 and miR-590-3p regulate human mesenchymal stem cell aging via direct targeting of AIMP3/p18. Lee S, et al. Age (Dordr), 2014. PMID 25465621, Free PMC Article
  5. The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR. Park BJ, et al. Cell, 2005 Jan 28. PMID 15680327

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of aminoacyl-tRNA synthetase multienzyme complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
eukaryotic translation elongation factor 1 epsilon-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106106.1 → NP_001099576.1  eukaryotic translation elongation factor 1 epsilon-1

    See identical proteins and their annotated locations for NP_001099576.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473977
    UniProtKB/TrEMBL
    A0A8I6AE61, B2RYN3
    Related
    ENSRNOP00000092572.1, ENSRNOT00000111273.1
    Conserved Domains (1) summary
    cd10305
    Location:65 → 165
    GST_C_AIMP3; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    26354247..26364953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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