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Nqo2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291084, updated on 2-Nov-2024

Summary

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Official Symbol
Nqo2provided by RGD
Official Full Name
N-ribosyldihydronicotinamide:quinone dehydrogenase 2provided by RGD
Primary source
RGD:1303320
See related
EnsemblRapid:ENSRNOG00000017820 AllianceGenome:RGD:1303320
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including anion binding activity; dihydronicotinamide riboside quinone reductase activity; and melatonin binding activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of neuron apoptotic process; and positive regulation of vascular associated smooth muscle cell proliferation. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Parkinson's disease; agranulocytosis; breast cancer; and breast carcinoma. Orthologous to human NQO2 (N-ribosyldihydronicotinamide:quinone dehydrogenase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 214.6), Heart (RPKM 157.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nqo2 in Genome Data Viewer
Location:
17p12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (31114825..31144062, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (30909482..30938725, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (32131847..32158559, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene biphenyl hydrolase like Neighboring gene receptor interacting serine/threonine kinase 1 Neighboring gene serpin family B member 6A Neighboring gene uncharacterized LOC102554685 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 6e like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Resveratrol inhibits angiotensin II-induced ERK1/2 activation by downregulating quinone reductase 2 in rat vascular smooth muscle cells. Zhang X, et al. J Biomed Res, 2012 Mar. PMID 23554738, Free PMC Article
  2. Downregulation of quinone reductase 2 attenuates vascular smooth muscle cells proliferation and neointimal formation in balloon injured rat carotid artery. Zhang XW, et al. Cell Physiol Biochem, 2012. PMID 22508052
  3. The influence of NQO2 on the dysfunctional autophagy and oxidative stress induced in the hippocampus of rats and in SH-SY5Y cells by fluoride. Ran LY, et al. CNS Neurosci Ther, 2023 Apr. PMID 36650666, Free PMC Article
  4. Association of NRH:quinone oxidoreductase 2 gene promoter polymorphism with higher gene expression and increased susceptibility to Parkinson's disease. Wang W, et al. J Gerontol A Biol Sci Med Sci, 2008 Feb. PMID 18314446
  5. NQO2 gene is associated with clozapine-induced agranulocytosis. Ostrousky O, et al. Tissue Antigens, 2003 Dec. PMID 14617031

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The influence of NQO2 on the dysfunctional autophagy and oxidative stress induced in the hippocampus of rats and in SH-SY5Y cells by fluoride.
    Title: The influence of NQO2 on the dysfunctional autophagy and oxidative stress induced in the hippocampus of rats and in SH-SY5Y cells by fluoride.
  2. Downregulation of NQO2 significantly suppresses vascular smooth muscle cell proliferation and progression of neointimal formation after vascular injury.
    Title: Downregulation of quinone reductase 2 attenuates vascular smooth muscle cells proliferation and neointimal formation in balloon injured rat carotid artery.
  3. these data suggest a role for QR2 in cognitive behaviors
    Title: Loss of quinone reductase 2 function selectively facilitates learning behaviors.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC94180

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables FAD binding ISO
Inferred from Sequence Orthology
more info
  
enables NAD(P)H dehydrogenase (quinone) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chloride ion binding ISO
Inferred from Sequence Orthology
more info
  
enables dihydronicotinamide riboside quinone reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables electron transfer activity ISO
Inferred from Sequence Orthology
more info
  
enables melatonin binding ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on other nitrogenous compounds as donors ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables resveratrol binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in memory IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of vascular associated smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in quinone catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ribosyldihydronicotinamide dehydrogenase [quinone]
Names
N-ribosyldihydronicotinamide:quinone reductase 2
NAD(P)H dehydrogenase, quinone 2
NAD(P)H quinone dehydrogenase 2
NRH dehydrogenase [quinone] 2
NRH:quinone oxidoreductase 2
QR2
quinone reductase 2
ribosyldihydronicotinamide dehydrogenase
NP_001004214.1
XP_006253929.1
XP_006253930.1
XP_038951418.1
XP_038951419.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004214.1 → NP_001004214.1  ribosyldihydronicotinamide dehydrogenase [quinone]

    See identical proteins and their annotated locations for NP_001004214.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079157
    UniProtKB/Swiss-Prot
    Q6AY80
    UniProtKB/TrEMBL
    A6J7H5
    Related
    ENSRNOP00000024141.5, ENSRNOT00000024141.7
    Conserved Domains (1) summary
    pfam02525
    Location:4 → 212
    Flavodoxin_2; Flavodoxin-like fold

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    31114825..31144062 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253867.5 → XP_006253929.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform X1

    See identical proteins and their annotated locations for XP_006253929.1

    UniProtKB/Swiss-Prot
    Q6AY80
    UniProtKB/TrEMBL
    A6J7H5
    Conserved Domains (1) summary
    pfam02525
    Location:4 → 212
    Flavodoxin_2; Flavodoxin-like fold

  2. XM_039095491.2 → XP_038951419.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform X2

    UniProtKB/TrEMBL
    A6J7H5
    Conserved Domains (1) summary
    pfam02525
    Location:3 → 191
    Flavodoxin_2; Flavodoxin-like fold

  3. XM_006253868.4 → XP_006253930.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform X2

    UniProtKB/TrEMBL
    A6J7H5
    Conserved Domains (1) summary
    pfam02525
    Location:3 → 191
    Flavodoxin_2; Flavodoxin-like fold

  4. XM_039095490.2 → XP_038951418.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform X1

    UniProtKB/Swiss-Prot
    Q6AY80
    UniProtKB/TrEMBL
    A6J7H5
    Conserved Domains (1) summary
    pfam02525
    Location:4 → 212
    Flavodoxin_2; Flavodoxin-like fold
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AY80.3 GenPept UniProtKB/Swiss-Prot:Q6AY80

Gene LinkOut

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