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Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291103, updated on 2-Nov-2024

Summary

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Official Symbol
Uqcrfs1provided by RGD
Official Full Name
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1provided by RGD
Primary source
RGD:628838
See related
EnsemblRapid:ENSRNOG00000018281 AllianceGenome:RGD:628838
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
LRRGT00195
Summary
Predicted to enable oxidoreductase activity. Involved in response to hormone and response to xenobiotic stimulus. Located in mitochondrial membrane. Part of respiratory chain complex III. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency. Orthologous to several human genes including UQCRFS1 (ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 5521.8), Muscle (RPKM 4150.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Uqcrfs1 in Genome Data Viewer
Location:
17p12
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (34173787..34190952)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (33977908..33982478)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (35677984..35682262)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 22 Neighboring gene uncharacterized LOC108348556 Neighboring gene glycogenin 1, pseudogene 1 Neighboring gene angiotensin II receptor, type 1a Neighboring gene membrane bound O-acyltransferase domain containing 1 Neighboring gene non-POU domain containing, octamer-binding, pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning and sequence analysis of a cDNA encoding the Rieske iron-sulfur protein of rat mitochondrial cytochrome bc1 complex. Nishikimi M, et al. Biochem Biophys Res Commun, 1989 Feb 28. PMID 2538119
  2. Thyroid hormone regulation of nuclear-encoded mitochondrial inner membrane polypeptides of the liver. Joste V, et al. Eur J Biochem, 1989 Sep 1. PMID 2776768
  3. Molecular mechanisms of doxorubicin-induced cardiomyopathy. Selective suppression of Reiske iron-sulfur protein, ADP/ATP translocase, and phosphofructokinase genes is associated with ATP depletion in rat cardiomyocytes. Jeyaseelan R, et al. J Biol Chem, 1997 Feb 28. PMID 9038198
  4. Proteomic identification of the involvement of the mitochondrial rieske protein in epilepsy. Junker H, et al. Epilepsia, 2005 Mar. PMID 15730530
  5. Dephosphorylation of the Rieske iron-sulfur protein after induction of the mitochondrial permeability transition. He L, et al. Biochem Biophys Res Commun, 2005 Sep 2. PMID 16023995

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mass spectrometric characterization of ubiquinol-cytochrome c reductase; ten of the 11 polypeptides present in this complex were detected directly by MALDI-TOFMS following electroelution of the active complex
    Title: Mass spectrometric characterization of mitochondrial electron transport complexes: subunits of the rat heart ubiquinol-cytochrome c reductase.
  2. Conformational changes from phosphorylation & dephosphorylation of RISP may thus regulate mitochondrial permeability transition pore formation & conductance.
    Title: Dephosphorylation of the Rieske iron-sulfur protein after induction of the mitochondrial permeability transition.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC105530

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquinol-cytochrome-c reductase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex III assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in respiratory electron transport chain ISO
Inferred from Sequence Orthology
more info
  
involved_in respiratory electron transport chain ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to hormone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of respiratory chain complex III IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex III IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex III ISO
Inferred from Sequence Orthology
more info
  
part_of respiratory chain complex III TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
cytochrome b-c1 complex subunit Rieske, mitochondrial
Names
RISP
Rieske protein UQCRFS1
complex III subunit 5
cytochrome b-c1 complex subunit 5
liver regeneration-related protein LRRGT00195
rieske iron-sulfur protein
ubiquinol-cytochrome c reductase iron-sulfur subunit
NP_001008888.1
XP_063132254.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008888.1 → NP_001008888.1  cytochrome b-c1 complex subunit Rieske, mitochondrial

    See identical proteins and their annotated locations for NP_001008888.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085339
    UniProtKB/Swiss-Prot
    P20788, Q6QI13
    UniProtKB/TrEMBL
    A6J7M2, A6J7M3
    Conserved Domains (4) summary
    cd03470
    Location:151 → 274
    Rieske_cytochrome_bc1; Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including ...
    TIGR01416
    Location:114 → 274
    Rieske_proteo; ubiquinol-cytochrome c reductase, iron-sulfur subunit
    pfam02921
    Location:80 → 145
    UCR_TM; Ubiquinol cytochrome reductase transmembrane region
    pfam09165
    Location:2 → 77
    Ubiq-Cytc-red_N; Ubiquinol-cytochrome c reductase 8 kDa, N-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    34173787..34190952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276184.1 → XP_063132254.1  cytochrome b-c1 complex subunit Rieske, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    P20788, Q6QI13
    UniProtKB/TrEMBL
    A6J7M2
    Related
    ENSRNOP00000099852.1, ENSRNOT00000126950.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20788.2 GenPept UniProtKB/Swiss-Prot:P20788

Gene LinkOut

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