U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

BRD7 bromodomain containing 7 [ Homo sapiens (human) ]

Gene ID: 29117, updated on 3-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
BRD7provided by HGNC
Official Full Name
bromodomain containing 7provided by HGNC
Primary source
HGNC:HGNC:14310
See related
Ensembl:ENSG00000166164 MIM:618489; AllianceGenome:HGNC:14310
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BP75; NAG4; CELTIX1; SMARCI1
Summary
This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Expression
Ubiquitous expression in testis (RPKM 21.8), spleen (RPKM 16.7) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See BRD7 in Genome Data Viewer
Location:
16q12.1
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (50315957..50368988, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (56113791..56166835, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (50349868..50402899, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:50186273-50187230 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7476 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7477 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10808 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10809 Neighboring gene MPRA-validated peak2589 silencer Neighboring gene terminal nucleotidyltransferase 4B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:50217888-50218450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:50218451-50219012 Neighboring gene Sharpr-MPRA regulatory region 14159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10810 Neighboring gene Sharpr-MPRA regulatory region 8986 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:50278238-50278950 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:50278951-50279662 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7478 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:50280376-50281087 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:50288095-50288594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10811 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10812 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:50299606-50300199 Neighboring gene adenylate cyclase 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:50305212-50306046 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:50306047-50306881 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10814 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:50317845-50318346 Neighboring gene Sharpr-MPRA regulatory region 2137 Neighboring gene microRNA 6771 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:50347343-50348542 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:50353005-50354204 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10815 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10816 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7481 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7482 Neighboring gene Sharpr-MPRA regulatory region 13482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10817 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:50430839-50432038 Neighboring gene long intergenic non-protein coding RNA 2178 Neighboring gene uncharacterized LOC124903770

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRIM28 promotes tumor growth and metastasis in breast cancer by targeting the BRD7 protein for ubiquitination and degradation.
    Title: TRIM28 promotes tumor growth and metastasis in breast cancer by targeting the BRD7 protein for ubiquitination and degradation.
  2. Identification of BRD7 by whole-exome sequencing as a predictor for intermediate-stage hepatocellular carcinoma in patients undergoing TACE.
    Title: Identification of BRD7 by whole-exome sequencing as a predictor for intermediate-stage hepatocellular carcinoma in patients undergoing TACE.
  3. BRD7 inhibits enhancer activity and expression of BIRC2 to suppress tumor growth and metastasis in nasopharyngeal carcinoma.
    Title: BRD7 inhibits enhancer activity and expression of BIRC2 to suppress tumor growth and metastasis in nasopharyngeal carcinoma.
  4. Characterization of the Functional Interplay between the BRD7 and BRD9 Homologues in mSWI/SNF Complexes.
    Title: Characterization of the Functional Interplay between the BRD7 and BRD9 Homologues in mSWI/SNF Complexes.
  5. LncRNA LENGA acts as a tumor suppressor in gastric cancer through BRD7/TP53 signaling.
    Title: LncRNA LENGA acts as a tumor suppressor in gastric cancer through BRD7/TP53 signaling.
  6. BRD7 restrains TNF-alpha-induced proliferation and migration of airway smooth muscle cells by inhibiting notch signaling.
    Title: BRD7 restrains TNF-α-induced proliferation and migration of airway smooth muscle cells by inhibiting notch signaling.
  7. Bromodomain-containing protein 7 regulates matrix metabolism and apoptosis in human nucleus pulposus cells through the BRD7-PI3K-YAP1 signaling axis.
    Title: Bromodomain-containing protein 7 regulates matrix metabolism and apoptosis in human nucleus pulposus cells through the BRD7-PI3K-YAP1 signaling axis.
  8. Expression and subcellular localization of the bromodomain-containing protein 7 is a prognostic biomarker in breast cancer.
    Title: Expression and subcellular localization of the bromodomain-containing protein 7 is a prognostic biomarker in breast cancer.
  9. PARP1 induces the degradation of BRD7.
    Title: Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.
  10. c-Myc transactivates miR-141 expression and that BRD7, a direct target of c-Myc, serves as a cofactor of c-Myc and forms a negative feedback loop with c-Myc in miR-141 transcription in NPC.
    Title: BRD7 expression and c-Myc activation forms a double-negative feedback loop that controls the cell proliferation and tumor growth of nasopharyngeal carcinoma by targeting oncogenic miR-141.
Submit: New GeneRIF Correction See all GeneRIFs (43)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of liver enzymes in korean children.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lysine-acetylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysine-acetylated histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables p53 binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of T cell differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cell differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of double-strand break repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of myoblast differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of G0 to G1 transition NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of G1/S transition of mitotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic metaphase/anaphase transition NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of nucleotide-excision repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in transcription initiation-coupled chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of RSC-type complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in chromatin NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in kinetochore NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nuclear matrix NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
bromodomain-containing protein 7
Names
75 kDa bromodomain protein
protein CELTIX-1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023418.2 RefSeqGene

    Range
    5000..58031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001173984.3 → NP_001167455.1  bromodomain-containing protein 7 isoform 1

    See identical proteins and their annotated locations for NP_001167455.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC007493, AC007597, AF152604, AF213969, AW615116
    Consensus CDS
    CCDS54007.1
    UniProtKB/TrEMBL
    A0AA34QW01
    Related
    ENSP00000378181.2, ENST00000394689.2
    Conserved Domains (2) summary
    cd05513
    Location:135 → 232
    Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
    pfam12024
    Location:287 → 533
    DUF3512; Domain of unknown function (DUF3512)

  2. NM_013263.5 → NP_037395.2  bromodomain-containing protein 7 isoform 2

    See identical proteins and their annotated locations for NP_037395.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks one internal residue, compared to isoform 1.
    Source sequence(s)
    AC007493, AC007597, AF152604, AW615116, DA645362
    Consensus CDS
    CCDS10742.1
    UniProtKB/Swiss-Prot
    Q4VC09, Q8N2L9, Q96KA4, Q9BV48, Q9NPI1, Q9UH59
    UniProtKB/TrEMBL
    A0AA34QW01
    Related
    ENSP00000378180.3, ENST00000394688.8
    Conserved Domains (2) summary
    cd05513
    Location:135 → 232
    Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
    pfam12024
    Location:287 → 532
    DUF3512; Domain of unknown function (DUF3512)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    50315957..50368988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023180.2 → XP_016878669.1  bromodomain-containing protein 7 isoform X6

    UniProtKB/TrEMBL
    A0AA34QW01

  2. XM_017023179.2 → XP_016878668.1  bromodomain-containing protein 7 isoform X5

    UniProtKB/TrEMBL
    A0AA34QW01

  3. XM_011523049.3 → XP_011521351.1  bromodomain-containing protein 7 isoform X4

    UniProtKB/TrEMBL
    A0AA34QW01
    Conserved Domains (2) summary
    cd05513
    Location:152 → 249
    Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
    pfam12024
    Location:304 → 513
    DUF3512; Domain of unknown function (DUF3512)

  4. XM_011523048.3 → XP_011521350.1  bromodomain-containing protein 7 isoform X3

    UniProtKB/TrEMBL
    A0AA34QW01
    Conserved Domains (2) summary
    cd05513
    Location:152 → 249
    Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
    pfam12024
    Location:304 → 514
    DUF3512; Domain of unknown function (DUF3512)

  5. XM_011523047.3 → XP_011521349.1  bromodomain-containing protein 7 isoform X2

    UniProtKB/TrEMBL
    A0AA34QVS2, A0AA34QW01
    Related
    ENSP00000518227.1, ENST00000710356.1
    Conserved Domains (2) summary
    cd05513
    Location:152 → 249
    Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
    pfam12024
    Location:304 → 549
    DUF3512; Domain of unknown function (DUF3512)

  6. XM_011523046.4 → XP_011521348.1  bromodomain-containing protein 7 isoform X1

    UniProtKB/TrEMBL
    A0AA34QW01
    Conserved Domains (2) summary
    cd05513
    Location:152 → 249
    Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
    pfam12024
    Location:304 → 550
    DUF3512; Domain of unknown function (DUF3512)

  7. XM_047434006.1 → XP_047289962.1  bromodomain-containing protein 7 isoform X7

  8. XM_011523050.4 → XP_011521352.1  bromodomain-containing protein 7 isoform X10

    Conserved Domains (2) summary
    pfam12024
    Location:85 → 331
    DUF3512; Domain of unknown function (DUF3512)
    cl02556
    Location:1 → 30
    Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

  9. XM_047434008.1 → XP_047289964.1  bromodomain-containing protein 7 isoform X9

  10. XM_047434007.1 → XP_047289963.1  bromodomain-containing protein 7 isoform X8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    56113791..56166835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054380174.1 → XP_054236149.1  bromodomain-containing protein 7 isoform X6

  2. XM_054380173.1 → XP_054236148.1  bromodomain-containing protein 7 isoform X5

  3. XM_054380172.1 → XP_054236147.1  bromodomain-containing protein 7 isoform X4

  4. XM_054380171.1 → XP_054236146.1  bromodomain-containing protein 7 isoform X3

  5. XM_054380170.1 → XP_054236145.1  bromodomain-containing protein 7 isoform X2

    UniProtKB/TrEMBL
    A0AA34QVS2

  6. XM_054380169.1 → XP_054236144.1  bromodomain-containing protein 7 isoform X1

  7. XM_054380175.1 → XP_054236150.1  bromodomain-containing protein 7 isoform X7

  8. XM_054380178.1 → XP_054236153.1  bromodomain-containing protein 7 isoform X10

  9. XM_054380177.1 → XP_054236152.1  bromodomain-containing protein 7 isoform X9

  10. XM_054380176.1 → XP_054236151.1  bromodomain-containing protein 7 isoform X8

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NPI1.1 GenPept UniProtKB/Swiss-Prot:Q9NPI1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous