Ptgr3 prostaglandin reductase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptgr3provided by RGD
Official Full Name: prostaglandin reductase 3provided by RGD
Primary source: RGD:1309999
See related: EnsemblRapid:ENSRNOG00000016239 AllianceGenome:RGD:1309999
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Zadh2
Summary: Predicted to enable 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity. Predicted to be involved in negative regulation of fat cell differentiation. Predicted to be located in mitochondrion and peroxisome. Orthologous to human PTGR3 (prostaglandin reductase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 119.3), Liver (RPKM 86.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.3

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (79729282..79738632)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (77454435..77463785)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (80939875..80949226)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH139406 (e-PCR)
- UniSTS:221492

RH128293 (e-PCR)
- UniSTS:211601

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prostaglandin reductase 3

Names: zinc binding alcohol dehydrogenase, domain containing 2; zinc-binding alcohol dehydrogenase domain-containing protein 2

NP_001099599.1

EC 1.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106129.1 → NP_001099599.1 prostaglandin reductase 3

See identical proteins and their annotated locations for NP_001099599.1

Status: PROVISIONAL

Source sequence(s)

CH474021

UniProtKB/TrEMBL

A6K5K8, D4A264

Related

ENSRNOP00000021729.7, ENSRNOT00000021729.8

Conserved Domains (2) summary

cd08250
Location:32 → 368

Mgc45594_like; Mgc45594 gene product and other MDR family members

COG0604
Location:33 → 368

Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]