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Afap1l1 actin filament associated protein 1-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291565, updated on 17-Aug-2024

Summary

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Official Symbol
Afap1l1provided by RGD
Official Full Name
actin filament associated protein 1-like 1provided by RGD
Primary source
RGD:1311580
See related
EnsemblRapid:ENSRNOG00000019403 AllianceGenome:RGD:1311580
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311580
Summary
Predicted to enable SH3 domain binding activity. Predicted to be located in cell junction; cell projection; and podosome. Predicted to be active in cytosol. Orthologous to human AFAP1L1 (actin filament associated protein 1 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 193.0), Heart (RPKM 128.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
18q12.1
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (57454120..57514584, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (55183786..55244174, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (57052659..57114589, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene prenylcysteine oxidase 1 like Neighboring gene uncharacterized LOC134482948 Neighboring gene GrpE-like 2, mitochondrial Neighboring gene actin binding LIM protein family, member 3 Neighboring gene uncharacterized LOC120098202

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH3 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in podosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
actin filament-associated protein 1-like 1
Names
AFAP1-like protein 1
actin filament-associated protein, 110 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106142.1 → NP_001099612.1  actin filament-associated protein 1-like 1

    See identical proteins and their annotated locations for NP_001099612.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473971
    UniProtKB/Swiss-Prot
    D4AB98
    UniProtKB/TrEMBL
    A0A8I6AWR7
    Related
    ENSRNOP00000097752.1, ENSRNOT00000109591.2
    Conserved Domains (3) summary
    cd13306
    Location:209 → 314
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:418 → 517
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:225 → 315
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    57454120..57514584 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254794.5 → XP_006254856.3  actin filament-associated protein 1-like 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AWR7, A0A8L2QEB4
    Related
    ENSRNOP00000026495.5, ENSRNOT00000026495.6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D4AB98.1 GenPept UniProtKB/Swiss-Prot:D4AB98

Gene LinkOut

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