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Sil1 SIL1 nucleotide exchange factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 291673, updated on 2-Nov-2024

Summary

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Official Symbol
Sil1provided by RGD
Official Full Name
SIL1 nucleotide exchange factorprovided by RGD
Primary source
RGD:735103
See related
EnsemblRapid:ENSRNOG00000019826 AllianceGenome:RGD:735103
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable adenyl-nucleotide exchange factor activity and identical protein binding activity. Predicted to be involved in protein transport. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in primary cerebellar degeneration. Orthologous to human SIL1 (SIL1 nucleotide exchange factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 100.2), Testes (RPKM 98.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sil1 in Genome Data Viewer
Location:
18p11
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (27146526..27378459, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (26872423..27104365, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (28067476..28302008, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene transfer RNA proline (anticodon AGG) 77 Neighboring gene catenin alpha 1 Neighboring gene leucine rich repeat transmembrane neuronal 2 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC102550858 Neighboring gene uncharacterized LOC120098220

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Protein accumulation and neurodegeneration in the woozy mutant mouse is caused by disruption of SIL1, a cochaperone of BiP. Zhao L, et al. Nat Genet, 2005 Sep. PMID 16116427
  2. BAP, a mammalian BiP-associated protein, is a nucleotide exchange factor that regulates the ATPase activity of BiP. Chung KT, et al. J Biol Chem, 2002 Dec 6. PMID 12356756
  3. Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Palmer DJ, et al. Proteomics, 2006 Apr. PMID 16502470
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC72590

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables adenyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nucleotide exchange factor SIL1
Names
SIL1 homolog, endoplasmic reticulum chaperone

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199376.1 → NP_955408.1  nucleotide exchange factor SIL1 precursor

    See identical proteins and their annotated locations for NP_955408.1

    Status: PROVISIONAL

    Source sequence(s)
    BC062050
    UniProtKB/Swiss-Prot
    Q6P6S4
    UniProtKB/TrEMBL
    A0A8I6ANJ4, A6J2X3
    Conserved Domains (1) summary
    pfam08609
    Location:197 → 226
    Fes1; Nucleotide exchange factor Fes1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    27146526..27378459 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008772025.4 → XP_008770247.1  nucleotide exchange factor SIL1 isoform X1

    See identical proteins and their annotated locations for XP_008770247.1

    UniProtKB/Swiss-Prot
    Q6P6S4
    UniProtKB/TrEMBL
    A0A8I6ANJ4, A6J2X3
    Conserved Domains (1) summary
    pfam08609
    Location:197 → 226
    Fes1; Nucleotide exchange factor Fes1

  2. XM_017600905.3 → XP_017456394.1  nucleotide exchange factor SIL1 isoform X1

    UniProtKB/Swiss-Prot
    Q6P6S4
    UniProtKB/TrEMBL
    A0A8I6ANJ4, A6J2X3
    Related
    ENSRNOP00000097662.1, ENSRNOT00000102716.2
    Conserved Domains (1) summary
    pfam08609
    Location:197 → 226
    Fes1; Nucleotide exchange factor Fes1

  3. XM_039096718.2 → XP_038952646.1  nucleotide exchange factor SIL1 isoform X1

    UniProtKB/Swiss-Prot
    Q6P6S4
    UniProtKB/TrEMBL
    A0A8I6ANJ4, A6J2X3

  4. XM_039096720.2 → XP_038952648.1  nucleotide exchange factor SIL1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZSQ7
    Related
    ENSRNOP00000078831.1, ENSRNOT00000104681.2

  5. XM_039096722.2 → XP_038952650.1  nucleotide exchange factor SIL1 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P6S4.1 GenPept UniProtKB/Swiss-Prot:Q6P6S4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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