U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Brd8 bromodomain containing 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291691, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Brd8provided by RGD
Official Full Name
bromodomain containing 8provided by RGD
Primary source
RGD:1307003
See related
EnsemblRapid:ENSRNOG00000020340 AllianceGenome:RGD:1307003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
p120
Summary
Predicted to enable nuclear receptor coactivator activity and nuclear thyroid hormone receptor binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of NuA4 histone acetyltransferase complex; Swr1 complex; and nucleosome. Biomarker of colorectal adenocarcinoma. Orthologous to human BRD8 (bromodomain containing 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 114.2), Testes (RPKM 94.2) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Brd8 in Genome Data Viewer
Location:
18p12
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (26455824..26504106, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (26204892..26229999, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (27375645..27423989, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene Wnt family member 8A Neighboring gene uncharacterized LOC134482927 Neighboring gene NME/NM23 family member 5 Neighboring gene kinesin family member 20A Neighboring gene cell division cycle 23 Neighboring gene GDNF family receptor alpha 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Effects of nicorandil on p120 expression in the spinal cord and dorsal root ganglion of rats with chronic postsurgical pain. Huang SS, et al. Mol Med Rep, 2020 Dec. PMID 33173987, Free PMC Article
  2. Co-activator p120 is increased by gonadotropins in the rat ovary and enhances progesterone receptor activity. Yoshino M, et al. Reprod Biol Endocrinol, 2006 Oct 3. PMID 17014737, Free PMC Article
  3. BRD8 is a potential chemosensitizing target for spindle poisons in colorectal cancer therapy. Yamada HY, et al. Int J Oncol, 2009 Nov. PMID 19787264
  4. ANP32E is a histone chaperone that removes H2A.Z from chromatin. Obri A, et al. Nature, 2014 Jan 30. PMID 24463511
  5. The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics. Watanabe S, et al. Cold Spring Harb Symp Quant Biol, 2010. PMID 21502417

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Effects of nicorandil on p120 expression in the spinal cord and dorsal root ganglion of rats with chronic postsurgical pain.
    Title: Effects of nicorandil on p120 expression in the spinal cord and dorsal root ganglion of rats with chronic postsurgical pain.
  2. BRD8 expression is associated with tumor progression toward advanced stages
    Title: BRD8 is a potential chemosensitizing target for spindle poisons in colorectal cancer therapy.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables nuclear thyroid hormone receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to thyroid hormone stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NuA4 histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Swr1 complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
bromodomain-containing protein 8

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008509.1 → NP_001008509.1  bromodomain-containing protein 8 isoform 2

    See identical proteins and their annotated locations for NP_001008509.1

    Status: VALIDATED

    Source sequence(s)
    AB180485
    UniProtKB/TrEMBL
    A0A8I6ATL0, Q5TLG7
    Related
    ENSRNOP00000076647.2, ENSRNOT00000118939.2
    Conserved Domains (1) summary
    cd05507
    Location:788 → 891
    Bromo_brd8_like; Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be ...

  2. NM_001414410.1 → NP_001401339.1  bromodomain-containing protein 8 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    Related
    ENSRNOP00000069953.2, ENSRNOT00000087968.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    26455824..26504106 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277225.1 → XP_063133295.1  bromodomain-containing protein 8 isoform X3

  2. XM_063277224.1 → XP_063133294.1  bromodomain-containing protein 8 isoform X2

    UniProtKB/TrEMBL
    F1M858
    Related
    ENSRNOP00000033259.6, ENSRNOT00000034385.7

  3. XM_063277223.1 → XP_063133293.1  bromodomain-containing protein 8 isoform X1

    Related
    ENSRNOP00000095490.2, ENSRNOT00000101754.2

  4. XM_063277234.1 → XP_063133304.1  bromodomain-containing protein 8 isoform X14

  5. XM_063277233.1 → XP_063133303.1  bromodomain-containing protein 8 isoform X14

  6. XM_063277229.1 → XP_063133299.1  bromodomain-containing protein 8 isoform X10

  7. XM_006254564.5 → XP_006254626.1  bromodomain-containing protein 8 isoform X8

    UniProtKB/TrEMBL
    A0A0G2JWN9
    Conserved Domains (1) summary
    cd05507
    Location:709 → 812
    Bromo_brd8_like; Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be ...

  8. XM_017600912.3 → XP_017456401.1  bromodomain-containing protein 8 isoform X9

    UniProtKB/TrEMBL
    A0A0G2JWN9

  9. XM_063277228.1 → XP_063133298.1  bromodomain-containing protein 8 isoform X7

    UniProtKB/TrEMBL
    A0A8I6AR97
    Related
    ENSRNOP00000095492.1, ENSRNOT00000106891.2

  10. XM_039096725.2 → XP_038952653.1  bromodomain-containing protein 8 isoform X5

    UniProtKB/TrEMBL
    A0A0G2JWN9, E9PTN1
    Related
    ENSRNOP00000050917.3, ENSRNOT00000048752.5
    Conserved Domains (3) summary
    cd05507
    Location:782 → 885
    Bromo_brd8_like; Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be ...
    PHA03247
    Location:176 → 419
    PHA03247; large tegument protein UL36; Provisional
    PRK14971
    Location:356 → 484
    PRK14971; DNA polymerase III subunit gamma/tau

  11. XM_063277227.1 → XP_063133297.1  bromodomain-containing protein 8 isoform X6

    UniProtKB/TrEMBL
    A0A8I5XUT9

  12. XM_063277226.1 → XP_063133296.1  bromodomain-containing protein 8 isoform X4

  13. XM_063277231.1 → XP_063133301.1  bromodomain-containing protein 8 isoform X12

  14. XM_063277232.1 → XP_063133302.1  bromodomain-containing protein 8 isoform X13

  15. XM_063277230.1 → XP_063133300.1  bromodomain-containing protein 8 isoform X11

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools