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Ino80c INO80 complex subunit C [ Rattus norvegicus (Norway rat) ]

Gene ID: 291737, updated on 17-Aug-2024

Summary

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Official Symbol
Ino80cprovided by RGD
Official Full Name
INO80 complex subunit Cprovided by RGD
Primary source
RGD:1310199
See related
EnsemblRapid:ENSRNOG00000016532 AllianceGenome:RGD:1310199
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310199
Summary
Predicted to be involved in chromatin remodeling. Predicted to be part of Ino80 complex and MLL1 complex. Orthologous to human INO80C (INO80 complex subunit C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 130.2), Muscle (RPKM 129.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ino80c in Genome Data Viewer
Location:
18p12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (15653508..15752455, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (15378764..15398574, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (15995005..16009639, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene proline-rich nuclear receptor coactivator 1. pseudogene 1 Neighboring gene zinc finger protein 24 Neighboring gene U6 spliceosomal RNA Neighboring gene polypeptide N-acetylgalactosaminyltransferase 1 Neighboring gene ribosomal protein L29 like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. Chen L, et al. J Biol Chem, 2011 Apr 1. PMID 21303910, Free PMC Article
  2. The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics. Watanabe S, et al. Cold Spring Harb Symp Quant Biol, 2010. PMID 21502417
  3. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Dou Y, et al. Cell, 2005 Jun 17. PMID 15960975
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC109171

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomere maintenance in response to DNA damage ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA strand elongation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chromosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Ino80 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ino80 complex IEA
Inferred from Electronic Annotation
more info
  
part_of Ino80 complex ISO
Inferred from Sequence Orthology
more info
  
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of MLL1 complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
INO80 complex subunit C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017446.2 → NP_001017446.1  INO80 complex subunit C isoform 1

    See identical proteins and their annotated locations for NP_001017446.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    Q5BJY3
    UniProtKB/TrEMBL
    A6J2J9
    Related
    ENSRNOP00000022169.5, ENSRNOT00000022169.8
    Conserved Domains (1) summary
    cl02154
    Location:65 → 186
    YL1_C; YL1 nuclear protein C-terminal domain

  2. NM_001428709.1 → NP_001415638.1  INO80 complex subunit C isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    15653508..15752455 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277257.1 → XP_063133327.1  INO80 complex subunit C isoform X2

  2. XM_039096736.2 → XP_038952664.1  INO80 complex subunit C isoform X1

    Conserved Domains (1) summary
    cl02154
    Location:28 → 149
    YL1_C; YL1 nuclear protein C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BJY3.1 GenPept UniProtKB/Swiss-Prot:Q5BJY3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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