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Dsc1 desmocollin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291759, updated on 2-Nov-2024

Summary

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Symbol
Dsc1provided by RGD
Full Name
desmocollin 1provided by RGD
Primary source
RGD:1310768
See related
EnsemblRapid:ENSRNOG00000056258 AllianceGenome:RGD:1310768
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in desmosome. Orthologous to human DSC1 (desmocollin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 45.1), Testes (RPKM 20.3) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Dsc1 in Genome Data Viewer
Location:
18p12
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (11774711..11831868, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (11499936..11556801, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (11877918..11906828, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 gamma, pseudogene 2 Neighboring gene desmocollin 2 Neighboring gene leucine aminopeptidase 3, pseudogene 1 Neighboring gene ribosomal protein L3, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues. Abe D, et al. J Periodontal Res, 2011 Jun. PMID 21382035
  2. Assessment of splice variant-specific functions of desmocollin 1 in the skin. Cheng X, et al. Mol Cell Biol, 2004 Jan. PMID 14673151, Free PMC Article
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in desmosome ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
desmocollin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106161.3 → NP_001099631.2  desmocollin-1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A0G2KA90
    Related
    ENSRNOP00000075307.2, ENSRNOT00000078207.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    11774711..11831868 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097287.2 → XP_038953215.1  desmocollin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GE75
    Conserved Domains (3) summary
    cd11304
    Location:105 → 207
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam00028
    Location:216 → 319
    Cadherin; Cadherin domain
    pfam01049
    Location:704 → 747
    Cadherin_C; Cadherin cytoplasmic region

  2. XM_039097286.2 → XP_038953214.1  desmocollin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GE75
    Conserved Domains (3) summary
    cd11304
    Location:105 → 207
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam00028
    Location:216 → 319
    Cadherin; Cadherin domain
    pfam01049
    Location:704 → 747
    Cadherin_C; Cadherin cytoplasmic region
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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