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Usp14 ubiquitin specific peptidase 14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291796, updated on 2-Nov-2024

Summary

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Official Symbol
Usp14provided by RGD
Official Full Name
ubiquitin specific peptidase 14provided by RGD
Primary source
RGD:1311825
See related
EnsemblRapid:ENSRNOG00000014981 AllianceGenome:RGD:1311825
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable deubiquitinase activity; endopeptidase inhibitor activity; and proteasome binding activity. Predicted to be involved in negative regulation of proteolysis involved in protein catabolic process; protein K48-linked deubiquitination; and regulation of chemotaxis. Predicted to act upstream of or within chemical synaptic transmission. Predicted to be located in several cellular components, including cell surface; cytoplasmic vesicle; and cytosol. Predicted to be part of proteasome complex. Predicted to be active in glutamatergic synapse and presynaptic cytosol. Orthologous to human USP14 (ubiquitin specific peptidase 14). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 487.9), Heart (RPKM 287.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Usp14 in Genome Data Viewer
Location:
18p13
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (1292745..1330867, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (1018111..1057727, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (1178785..1216573, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene SEC13 homolog, nuclear pore and COPII coat complex component, pseudogene 2 Neighboring gene uncharacterized LOC134482897 Neighboring gene THO complex subunit 1 Neighboring gene NDUFA4, mitochondrial complex associated, pseudogene 2 Neighboring gene Rho-associated coiled-coil containing protein kinase 1 Neighboring gene DNA-directed RNA polymerases I, II, and III subunit RPABC3-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Ubiquitin-specific protease 14 regulates cardiac hypertrophy progression by increasing GSK-3β phosphorylation. Liu N, et al. Biochem Biophys Res Commun, 2016 Sep 23. PMID 27545607
  2. Inhibition of deubiquitinating activity of USP14 decreases tyrosine hydroxylase phosphorylated at Ser19 in PC12D cells. Nakashima A, et al. Biochem Biophys Res Commun, 2016 Apr 15. PMID 26969276
  3. Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling. Jung H, et al. Oncogenesis, 2013 Aug 19. PMID 23958854, Free PMC Article
  4. Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease. Kiprowska MJ, et al. Biochim Biophys Acta Mol Basis Dis, 2017 Jun. PMID 28372990, Free PMC Article
  5. Post-endocytotic Deubiquitination and Degradation of the Metabotropic γ-Aminobutyric Acid Receptor by the Ubiquitin-specific Protease 14. Lahaie N, et al. J Biol Chem, 2016 Mar 25. PMID 26817839, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. pharmacologically inhibiting (with low or high IU1 concentrations) or genetically down-regulating USP14 fail to enhance proteasomal degradation of Ub-proteins or Tau in neurons.
    Title: Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease.
  2. mediates the development of cardiac hypertrophy by promoting GSK-3beta phosphorylation.
    Title: Ubiquitin-specific protease 14 regulates cardiac hypertrophy progression by increasing GSK-3β phosphorylation.
  3. Activation of proteasome degradation by IU-1, which is an inhibitor for the deubiquitinating activity of USP14, decreased only the quantity of TH molecules phosphorylated at their Ser19.
    Title: Inhibition of deubiquitinating activity of USP14 decreases tyrosine hydroxylase phosphorylated at Ser19 in PC12D cells.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC95160

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables K63-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables proteasome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proteasome binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K48-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 14
Names
ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
ubiquitin specific protease 14
NP_001008302.1
XP_006254458.1
XP_006254460.1
XP_063133342.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008301.2 → NP_001008302.1  ubiquitin carboxyl-terminal hydrolase 14

    See identical proteins and their annotated locations for NP_001008302.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A8I5ZY29, Q5U2N2
    Related
    ENSRNOP00000020537.7, ENSRNOT00000020537.8
    Conserved Domains (2) summary
    cd02657
    Location:106 → 480
    Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
    cd16104
    Location:4 → 76
    Ubl_USP14_like; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 14 (USP14) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    1292745..1330867 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254396.4 → XP_006254458.1  ubiquitin carboxyl-terminal hydrolase 14 isoform X1

    See identical proteins and their annotated locations for XP_006254458.1

    UniProtKB/TrEMBL
    A0A8I5ZY29, Q5U2N2
    Conserved Domains (2) summary
    cd02657
    Location:106 → 480
    Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
    cd16104
    Location:4 → 76
    Ubl_USP14_like; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 14 (USP14) and similar proteins

  2. XM_006254398.5 → XP_006254460.1  ubiquitin carboxyl-terminal hydrolase 14 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZR30
    Related
    ENSRNOP00000069634.3, ENSRNOT00000084613.3
    Conserved Domains (2) summary
    cd02657
    Location:71 → 445
    Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
    cd16104
    Location:4 → 65
    Ubl_USP14_like; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 14 (USP14) and similar proteins

  3. XM_063277272.1 → XP_063133342.1  ubiquitin carboxyl-terminal hydrolase 14 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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