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Fto FTO, alpha-ketoglutarate dependent dioxygenase [ Rattus norvegicus (Norway rat) ]

Gene ID: 291905, updated on 2-Nov-2024

Summary

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Official Symbol
Ftoprovided by RGD
Official Full Name
FTO, alpha-ketoglutarate dependent dioxygenaseprovided by RGD
Primary source
RGD:1305121
See related
EnsemblRapid:ENSRNOG00000011728 AllianceGenome:RGD:1305121
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305121
Summary
Predicted to enable 2-oxoglutarate-dependent dioxygenase activity and ferrous iron binding activity. Involved in several processes, including negative regulation of eating behavior; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and response to bisphenol A. Predicted to be located in cytosol; nuclear speck; and plasma membrane. Used to study sciatic neuropathy. Biomarker of metabolic dysfunction-associated steatotic liver disease; obesity; transient cerebral ischemia; traumatic brain injury; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetic neuropathy; nuclear senile cataract; renal cell carcinoma (multiple); and type 2 diabetes mellitus. Orthologous to human FTO (FTO alpha-ketoglutarate dependent dioxygenase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 136.3), Kidney (RPKM 111.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fto in Genome Data Viewer
Location:
19p11
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (31456749..31865011, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (15284898..15692142, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (16774549..17115098, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483614 Neighboring gene iroquois homeobox 3 Neighboring gene uncharacterized LOC102556484 Neighboring gene Rpgrip1-like Neighboring gene uncharacterized LOC134483615

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Association between ACE (rs4646994), FABP2 (rs1799883), MTHFR (rs1801133), FTO (rs9939609) Genes Polymorphism and Type 2 Diabetes with Dyslipidemia. Raza ST, et al. Int J Mol Cell Med, 2017 Spring. PMID 28890888, Free PMC Article
  2. IDH2 contributes to tumorigenesis and poor prognosis by regulating m6A RNA methylation in multiple myeloma. Song S, et al. Oncogene, 2021 Sep. PMID 34274946
  3. Relationship between the FTO Genotype and Early Chronic Kidney Disease in Type 2 Diabetes: The Mediating Role of Central Obesity, Hypertension, and High Albuminuria. Marchetti J, et al. Lifestyle Genom, 2021. PMID 34134115
  4. The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain. Fredriksson R, et al. Endocrinology, 2008 May. PMID 18218688
  5. Effect of Pharmacological Inhibition of Fat-Mass and Obesity-Associated Protein on Nerve Trauma-Induced Pain Hypersensitivities. Zheng BX, et al. Neurotherapeutics, 2021 Jul. PMID 33829413, Free PMC Article

See all (98) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. USP18 Stabilized FTO Protein to Activate Mitophagy in Ischemic Stroke Through Repressing m6A Modification of SIRT6.
    Title: USP18 Stabilized FTO Protein to Activate Mitophagy in Ischemic Stroke Through Repressing m6A Modification of SIRT6.
  2. N6 methyladenosine eraser FTO suppresses Staphylococcus aureus-induced ferroptosis of bone marrow mesenchymal stem cells to ameliorate osteomyelitis through regulating the MDM2/TLR4/SLC7A11 signaling pathway.
    Title: N6 methyladenosine eraser FTO suppresses Staphylococcus aureus-induced ferroptosis of bone marrow mesenchymal stem cells to ameliorate osteomyelitis through regulating the MDM2/TLR4/SLC7A11 signaling pathway.
  3. FTO overexpression expedites wound healing and alleviates depression in burn rats through facilitating keratinocyte migration and angiogenesis via mediating TFPI-2 demethylation.
    Title: FTO overexpression expedites wound healing and alleviates depression in burn rats through facilitating keratinocyte migration and angiogenesis via mediating TFPI-2 demethylation.
  4. Fat mass and obesity-associated protein (FTO) affects midpalatal suture bone remodeling during rapid maxillary expansion.
    Title: Fat mass and obesity-associated protein (FTO) affects midpalatal suture bone remodeling during rapid maxillary expansion.
  5. FTO-mediated m[6]A demethylation regulates GnRH expression in the hypothalamus via the PLCbeta3/Ca[2+]/CAMK signalling pathway.
    Title: FTO-mediated m(6)A demethylation regulates GnRH expression in the hypothalamus via the PLCβ3/Ca(2+)/CAMK signalling pathway.
  6. N6-methyladenosine demethylase FTO regulates synaptic and cognitive impairment by destabilizing PTEN mRNA in hypoxic-ischemic neonatal rats.
    Title: N6-methyladenosine demethylase FTO regulates synaptic and cognitive impairment by destabilizing PTEN mRNA in hypoxic-ischemic neonatal rats.
  7. N6-methyladenosine demethylase FTO related to hyperandrogenism in PCOS via AKT pathway.
    Title: N6-methyladenosine demethylase FTO related to hyperandrogenism in PCOS via AKT pathway.
  8. Downregulation of FTO in the hippocampus is associated with mental disorders induced by fear stress during pregnancy.
    Title: Downregulation of FTO in the hippocampus is associated with mental disorders induced by fear stress during pregnancy.
  9. Downregulated FTO Promotes MicroRNA-155-mediated Inflammatory Response in Cerebral Ischemia/Reperfusion Injury.
    Title: Downregulated FTO Promotes MicroRNA-155-mediated Inflammatory Response in Cerebral Ischemia/Reperfusion Injury.
  10. FTO represses NLRP3-mediated pyroptosis and alleviates myocardial ischemia-reperfusion injury via inhibiting CBL-mediated ubiquitination and degradation of beta-catenin.
    Title: FTO represses NLRP3-mediated pyroptosis and alleviates myocardial ischemia-reperfusion injury via inhibiting CBL-mediated ubiquitination and degradation of β-catenin.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 2-oxoglutarate-dependent dioxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables broad specificity oxidative DNA demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables broad specificity oxidative DNA demethylase activity IEA
Inferred from Electronic Annotation
more info
  
enables broad specificity oxidative DNA demethylase activity ISO
Inferred from Sequence Orthology
more info
  
enables broad specificity oxidative DNA demethylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferrous iron binding IEA
Inferred from Electronic Annotation
more info
  
enables ferrous iron binding ISO
Inferred from Sequence Orthology
more info
  
enables ferrous iron binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables mRNA N6-methyladenosine dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA N6-methyladenosine dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA N6-methyladenosine dioxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables mRNA N6-methyladenosine dioxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables oxidative RNA demethylase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidative RNA demethylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables tRNA demethylase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA demethylase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA demethylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA alkylation repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA alkylation repair ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in adipose tissue development IEA
Inferred from Electronic Annotation
more info
  
involved_in adipose tissue development ISO
Inferred from Sequence Orthology
more info
  
involved_in heart development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in mRNA destabilization IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA destabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of eating behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of brown fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of lipid storage IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of lipid storage ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of respiratory system process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of respiratory system process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of white fat cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of white fat cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to bisphenol A IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in snRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in snRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in temperature homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in temperature homeostasis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
alpha-ketoglutarate-dependent dioxygenase FTO
Names
U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO
fat mass and obesity associated
fat mass and obesity-associated protein
m6A(m)-demethylase FTO
mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
mRNA N(6)-methyladenosine demethylase FTO
protein fto
tRNA N1-methyl adenine demethylase FTO
NP_001034802.1
XP_038953492.1
XP_038953493.1
XP_038953494.1
XP_038953495.1
XP_038953496.1
XP_063133931.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039713.1 → NP_001034802.1  alpha-ketoglutarate-dependent dioxygenase FTO

    See identical proteins and their annotated locations for NP_001034802.1

    Status: PROVISIONAL

    Source sequence(s)
    AM233906
    UniProtKB/Swiss-Prot
    Q2A121
    UniProtKB/TrEMBL
    A0A0G2K675, B4F7E0
    Related
    ENSRNOP00000015718.4, ENSRNOT00000015718.8
    Conserved Domains (2) summary
    pfam12933
    Location:36 → 322
    FTO_NTD; FTO catalytic domain
    pfam12934
    Location:326 → 495
    FTO_CTD; FTO C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    31456749..31865011 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097565.2 → XP_038953493.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X2

    UniProtKB/TrEMBL
    A0A0G2K675
    Conserved Domains (2) summary
    pfam12933
    Location:36 → 322
    FTO_NTD; FTO catalytic domain
    pfam12934
    Location:326 → 452
    FTO_CTD; FTO C-terminal domain

  2. XM_039097564.2 → XP_038953492.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X1

    UniProtKB/TrEMBL
    A0A0G2K675
    Conserved Domains (2) summary
    pfam12933
    Location:36 → 322
    FTO_NTD; FTO catalytic domain
    pfam12934
    Location:326 → 453
    FTO_CTD; FTO C-terminal domain

  3. XM_039097566.2 → XP_038953494.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X3

    Conserved Domains (2) summary
    pfam12933
    Location:6 → 151
    FTO_NTD; FTO catalytic domain
    pfam12934
    Location:155 → 323
    FTO_CTD; FTO C-terminal domain

  4. XM_063277861.1 → XP_063133931.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X3

  5. XM_039097568.2 → XP_038953496.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X3

    Conserved Domains (2) summary
    pfam12933
    Location:6 → 151
    FTO_NTD; FTO catalytic domain
    pfam12934
    Location:155 → 323
    FTO_CTD; FTO C-terminal domain

  6. XM_039097567.2 → XP_038953495.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X3

    Conserved Domains (2) summary
    pfam12933
    Location:6 → 151
    FTO_NTD; FTO catalytic domain
    pfam12934
    Location:155 → 323
    FTO_CTD; FTO C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2A121.1 GenPept UniProtKB/Swiss-Prot:Q2A121

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