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Lonp2 lon peptidase 2, peroxisomal [ Rattus norvegicus (Norway rat) ]

Gene ID: 291922, updated on 10-Oct-2024

Summary

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Official Symbol
Lonp2provided by RGD
Official Full Name
lon peptidase 2, peroxisomalprovided by RGD
Primary source
RGD:1305466
See related
EnsemblRapid:ENSRNOG00000015162 AllianceGenome:RGD:1305466
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
LRRGT00016; RGD1305466
Summary
Predicted to enable peptidase activity and protease binding activity. Involved in response to organic cyclic compound. Located in peroxisomal matrix. Orthologous to human LONP2 (lon peptidase 2, peroxisomal). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 999.5), Kidney (RPKM 539.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lonp2 in Genome Data Viewer
Location:
19p11
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (36580736..36672242, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (20407475..20498985, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (21400736..21492634, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547741 Neighboring gene siah E3 ubiquitin protein ligase 1 Neighboring gene U6 spliceosomal RNA Neighboring gene ATP binding cassette subfamily C member 12 Neighboring gene uncharacterized LOC134483622

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Induction of peroxisomal Lon protease in rat liver after di-(2-ethylhexyl)phthalate treatment. Yokota S, et al. Histochem Cell Biol, 2008 Jan. PMID 17929048
  2. Contribution of peroxisome-specific isoform of Lon protease in sorting PTS1 proteins to peroxisomes. Omi S, et al. J Biochem, 2008 May. PMID 18281296
  3. DNMT1 interacts with the developmental transcriptional repressor HESX1. Sajedi E, et al. Biochim Biophys Acta, 2008 Jan. PMID 17931718, Free PMC Article
  4. Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid β-oxidation in peroxisomal matrix. Okumoto K, et al. J Biol Chem, 2011 Dec 30. PMID 22002062, Free PMC Article
  5. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, et al. J Biol Chem, 2004 Jan 2. PMID 14561759

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into peroxisome matrix IEA
Inferred from Electronic Annotation
more info
  
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
  
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in protein quality control for misfolded or incompletely synthesized proteins IEA
Inferred from Electronic Annotation
more info
  
involved_in protein targeting to peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to peroxisome ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in peroxisomal matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisomal matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisomal matrix IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
lon protease homolog 2, peroxisomal
Names
lon protease 2
lon protease-like protein 2
peroxisomal Lon protease homolog 2
NP_001386125.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399196.1 → NP_001386125.1  lon protease homolog 2, peroxisomal

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/Swiss-Prot
    Q3MIB4
    UniProtKB/TrEMBL
    B2GUU4
    Related
    ENSRNOP00000020770.4, ENSRNOT00000020770.9
    Conserved Domains (1) summary
    COG0466
    Location:11 → 838
    Lon; ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    36580736..36672242 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033689.1: Suppressed sequence

    Description
    NM_001033689.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3MIB4.2 GenPept UniProtKB/Swiss-Prot:Q3MIB4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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