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Fhod1 formin homology 2 domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291964, updated on 2-Nov-2024

Summary

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Official Symbol
Fhod1provided by RGD
Official Full Name
formin homology 2 domain containing 1provided by RGD
Primary source
RGD:1589776
See related
EnsemblRapid:ENSRNOG00000054625 AllianceGenome:RGD:1589776
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in positive regulation of stress fiber assembly and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within establishment of centrosome localization and nuclear migration. Predicted to be located in several cellular components, including intercalated disc; nucleoplasm; and stress fiber. Orthologous to human FHOD1 (formin homology 2 domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 165.8), Muscle (RPKM 89.7) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fhod1 in Genome Data Viewer
Location:
19q11-q12
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (50116415..50135868, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (33206492..33225448, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37284923..37303855, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 29 Neighboring gene transmembrane protein 208 Neighboring gene solute carrier family 9 member A5 Neighboring gene pleckstrin homology and RhoGEF domain containing G4 Neighboring gene potassium channel tetramerization domain containing 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Novel signaling axis of FHOD1-RNF213-Col1α/Col3α in the pathogenesis of hypertension-induced tunica media thickening. Chen Y, et al. J Mol Cell Cardiol, 2023 Sep. PMID 37482037
  2. Distribution of formins in cardiac muscle: FHOD1 is a component of intercalated discs and costameres. Al Haj A, et al. Eur J Cell Biol, 2015 Feb. PMID 25555464
  3. Biochemical characterization of the diaphanous autoregulatory interaction in the formin homology protein FHOD1. Schönichen A, et al. J Biol Chem, 2006 Feb 24. PMID 16361249
  4. The mammalian formin FHOD1 is activated through phosphorylation by ROCK and mediates thrombin-induced stress fibre formation in endothelial cells. Takeya R, et al. EMBO J, 2008 Feb 20. PMID 18239683, Free PMC Article
  5. Oligomerization of the diaphanous-related formin FHOD1 requires a coiled-coil motif critical for its cytoskeletal and transcriptional activities. Madrid R, et al. FEBS Lett, 2005 Jan 17. PMID 15642356

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Novel signaling axis of FHOD1-RNF213-Col1alpha/Col3alpha in the pathogenesis of hypertension-induced tunica media thickening.
    Title: Novel signaling axis of FHOD1-RNF213-Col1α/Col3α in the pathogenesis of hypertension-induced tunica media thickening.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within establishment of centrosome localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nuclear migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intercalated disc ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
FH1/FH2 domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395129.1 → NP_001382058.1  FH1/FH2 domain-containing protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A0A0G2JZ38
    Related
    ENSRNOP00000070898.2, ENSRNOT00000084734.3
    Conserved Domains (3) summary
    PTZ00449
    Location:359 → 530
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam02181
    Location:631 → 1003
    FH2; Formin Homology 2 Domain
    pfam18382
    Location:17 → 115
    Formin_GBD_N; Formin N-terminal GTPase-binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    50116415..50135868 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008772483.4 → XP_008770705.1  FH1/FH2 domain-containing protein 1 isoform X1

    Conserved Domains (1) summary
    pfam02181
    Location:657 → 1029
    FH2; Formin Homology 2 Domain

  2. XM_039097608.2 → XP_038953536.1  FH1/FH2 domain-containing protein 1 isoform X2

    Conserved Domains (2) summary
    PTZ00449
    Location:267 → 463
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam02181
    Location:564 → 936
    FH2; Formin Homology 2 Domain

  3. XM_039097609.2 → XP_038953537.1  FH1/FH2 domain-containing protein 1 isoform X3

    Conserved Domains (3) summary
    PTZ00449
    Location:360 → 556
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam18382
    Location:17 → 115
    Formin_GBD_N; Formin N-terminal GTPase-binding domain
    cl19758
    Location:661 → 874
    FH2; Formin Homology 2 Domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001191600.1: Suppressed sequence

    Description
    NM_001191600.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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