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Dus2 dihydrouridine synthase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291978, updated on 17-Aug-2024

Summary

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Official Symbol
Dus2provided by RGD
Official Full Name
dihydrouridine synthase 2provided by RGD
Primary source
RGD:1305612
See related
EnsemblRapid:ENSRNOG00000019819 AllianceGenome:RGD:1305612
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dus2l; RGD1305612
Summary
Predicted to enable several functions, including double-stranded RNA binding activity; nucleotide binding activity; and protein kinase inhibitor activity. Predicted to be involved in negative regulation of cell death and tRNA dihydrouridine synthesis. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human DUS2 (dihydrouridine synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 53.6), Adrenal (RPKM 38.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
19q12
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (50816306..50864559)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (33906517..33954922)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37990374..38033590)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene dipeptidase 3 Neighboring gene dipeptidase 2 Neighboring gene DEAD-box helicase 28 Neighboring gene nuclear factor of activated T-cells 3 Neighboring gene epithelial splicing regulatory protein 2 Neighboring gene phospholipase A2, group XV

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. An extended dsRBD is required for post-transcriptional modification in human tRNAs. Bou-Nader C, et al. Nucleic Acids Res, 2015 Oct 30. PMID 26429968, Free PMC Article
  2. Interaction of human tRNA-dihydrouridine synthase-2 with interferon-induced protein kinase PKR. Mittelstadt M, et al. Nucleic Acids Res, 2008 Feb. PMID 18096616, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables FMN binding ISO
Inferred from Sequence Orthology
more info
  
enables NADPH binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA dihydrouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA dihydrouridine synthase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA dihydrouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA dihydrouridine synthesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
NP_001099651.1
XP_017456720.1
XP_017456721.1
XP_038953546.1
XP_038953547.2
XP_038953548.1
XP_038953550.1
XP_038953551.1
XP_063133996.1
XP_063133997.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106181.1 → NP_001099651.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like

    See identical proteins and their annotated locations for NP_001099651.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473972
    UniProtKB/TrEMBL
    A0A8I5ZYR8, A6IYV4, B0BN89, F7FLX6
    Related
    ENSRNOP00000107611.1, ENSRNOT00000128652.1
    Conserved Domains (2) summary
    cd02801
    Location:13 → 252
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    cd19871
    Location:369 → 436
    DSRM_DUS2L; double-stranded RNA binding motif of tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2L) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    50816306..50864559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097618.2 → XP_038953546.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZYR8, A6IYV4, B0BN89, F7FLX6
    Related
    ENSRNOP00000026827.6, ENSRNOT00000026827.7
    Conserved Domains (2) summary
    cd02801
    Location:13 → 252
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    cd19871
    Location:369 → 436
    DSRM_DUS2L; double-stranded RNA binding motif of tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2L) and similar proteins

  2. XM_017601232.3 → XP_017456721.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZYR8

  3. XM_017601231.3 → XP_017456720.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZYR8, A6IYV4, B0BN89, F7FLX6
    Conserved Domains (2) summary
    cd02801
    Location:13 → 252
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    cd19871
    Location:369 → 436
    DSRM_DUS2L; double-stranded RNA binding motif of tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2L) and similar proteins

  4. XM_039097620.2 → XP_038953548.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X3

    UniProtKB/TrEMBL
    A6IYV5
    Conserved Domains (2) summary
    cd02801
    Location:1 → 139
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    cd19871
    Location:256 → 323
    DSRM_DUS2L; double-stranded RNA binding motif of tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2L) and similar proteins

  5. XM_039097622.2 → XP_038953550.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X4

    Conserved Domains (2) summary
    cd19871
    Location:213 → 280
    DSRM_DUS2L; double-stranded RNA binding motif of tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2L) and similar proteins
    cl21457
    Location:29 → 96
    TIM; TIM-like beta/alpha barrel domains

  6. XM_063277926.1 → XP_063133996.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X4

  7. XM_039097623.2 → XP_038953551.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X4

    Conserved Domains (2) summary
    cd19871
    Location:213 → 280
    DSRM_DUS2L; double-stranded RNA binding motif of tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (DUS2L) and similar proteins
    cl21457
    Location:29 → 96
    TIM; TIM-like beta/alpha barrel domains

  8. XM_039097619.2 → XP_038953547.2  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X3

    UniProtKB/TrEMBL
    A6IYV5

  9. XM_063277927.1 → XP_063133997.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X5

Nucleotide Protein Strain
Heading Accession and Version

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