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Dpep2 dipeptidase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291984, updated on 16-Aug-2024

Summary

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Official Symbol
Dpep2provided by RGD
Official Full Name
dipeptidase 2provided by RGD
Primary source
RGD:1305746
See related
EnsemblRapid:ENSRNOG00000023303 AllianceGenome:RGD:1305746
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable dipeptidase activity. Predicted to be involved in leukotriene metabolic process. Predicted to be anchored component of membrane. Orthologous to human DPEP2 (dipeptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 98.0), Lung (RPKM 74.0) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19q12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (50795322..50806320, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (33883557..33896487, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37964098..37975154, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098640 Neighboring gene solute carrier family 12 member 4 Neighboring gene dipeptidase 3 Neighboring gene dihydrouridine synthase 2 Neighboring gene DEAD-box helicase 28 Neighboring gene nuclear factor of activated T-cells 3 Neighboring gene epithelial splicing regulatory protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of two additional members of the membrane-bound dipeptidase family. Habib GM, et al. FASEB J, 2003 Jul. PMID 12738806
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables dipeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables dipeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables exopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallodipeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in leukotriene D4 catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in leukotriene D4 catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in leukotriene D4 catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in leukotriene metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in leukotriene metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dipeptidase 2
NP_001011928.1
XP_008770709.1
XP_038953556.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011928.1 → NP_001011928.1  dipeptidase 2 precursor

    See identical proteins and their annotated locations for NP_001011928.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088195
    UniProtKB/Swiss-Prot
    Q5M872
    UniProtKB/TrEMBL
    A0A8L2QGJ8
    Related
    ENSRNOP00000031955.6, ENSRNOT00000034722.7
    Conserved Domains (1) summary
    pfam01244
    Location:80 → 400
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    50795322..50806320 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008772487.4 → XP_008770709.1  dipeptidase 2 isoform X2

    UniProtKB/TrEMBL
    A0A8L2QGJ8
    Conserved Domains (1) summary
    pfam01244
    Location:164 → 485
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

  2. XM_039097628.2 → XP_038953556.1  dipeptidase 2 isoform X1

    Conserved Domains (1) summary
    pfam01244
    Location:1 → 241
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

RNA

  1. XR_005496638.2 RNA Sequence

  2. XR_005496639.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5M872.1 GenPept UniProtKB/Swiss-Prot:Q5M872

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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