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Hydin Hydin, axonemal central pair apparatus protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 292017, updated on 2-Nov-2024

Summary

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Official Symbol
Hydinprovided by RGD
Official Full Name
Hydin, axonemal central pair apparatus proteinprovided by RGD
Primary source
RGD:1562254
See related
EnsemblRapid:ENSRNOG00000017178 AllianceGenome:RGD:1562254
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in axonemal central apparatus assembly and cilium movement. Predicted to act upstream of or within epithelial cell development; trachea development; and ventricular system development. Predicted to be located in axonemal central pair projection. Predicted to be active in axoneme. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 5. Orthologous to human HYDIN (HYDIN axonemal central pair apparatus protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 65.9), Lung (RPKM 48.8) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hydin in Genome Data Viewer
Location:
19q12
Exon count:
90
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (55146382..55492660)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (38236996..38583271)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (41036507..41379634, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483364 Neighboring gene cap methyltransferase 2 Neighboring gene uncharacterized LOC134483367 Neighboring gene transfer RNA glycine (anticodon GCC) 10 Neighboring gene transfer RNA glycine (anticodon GCC) 9 Neighboring gene VAC14 component of PIKFYVE complex

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutations in Hydin impair ciliary motility in mice. Lechtreck KF, et al. J Cell Biol, 2008 Feb 11. PMID 18250199, Free PMC Article
  2. Hydrocephalus-3, a Murine mutant. II. Changes in the brain extracellular space. McLone DG, et al. Surg Neurol, 1973 Jul. PMID 4732188
  3. Congenital hydrocephalus in hy3 mice is caused by a frameshift mutation in Hydin, a large novel gene. Davy BE, et al. Hum Mol Genet, 2003 May 15. PMID 12719380
  4. The pathophysiology and morphology of murine hydrocephalus in Hy-3 and Ch mutants. Raimondi AJ, et al. Surg Neurol, 1973 Jan. PMID 4784576
  5. Ependymal cilia beating induces an actin network to protect centrioles against shear stress. Mahuzier A, et al. Nat Commun, 2018 Jun 11. PMID 29891944, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This paper describes a similar gene in mouse.
    Title: Congenital hydrocephalus in hy3 mice is caused by a frameshift mutation in Hydin, a large novel gene.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in axonemal central apparatus assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within axonemal central apparatus assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within brain development ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium movement IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cilium movement ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within epithelial cell development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within trachea development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ventricular system development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axonemal central apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in axonemal central pair projection ISO
Inferred from Sequence Orthology
more info
  
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
hydrocephalus-inducing protein homolog
Names
hydrocephalus inducing

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427650.1 → NP_001414579.1  hydrocephalus-inducing protein homolog

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    55146382..55492660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039098232.2 → XP_038954160.1  hydrocephalus-inducing protein homolog isoform X1

    UniProtKB/TrEMBL
    A0A0G2JXD6, F1LSN6
    Related
    ENSRNOP00000023117.7, ENSRNOT00000023117.8
    Conserved Domains (6) summary
    PTZ00121
    Location:2311 → 2616
    PTZ00121; MAEBL; Provisional
    PRK00279
    Location:2249 → 2305
    adk; adenylate kinase; Reviewed
    pfam17380
    Location:2313 → 2460
    DUF5401; Family of unknown function (DUF5401)
    pfam15780
    Location:538 → 637
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
    pfam17213
    Location:2051 → 2275
    Hydin_ADK; Hydin Adenylate kinase-like domain
    cl27657
    Location:227 → 302
    Motile_Sperm; MSP (Major sperm protein) domain

  2. XM_039098235.2 → XP_038954163.1  hydrocephalus-inducing protein homolog isoform X3

    UniProtKB/TrEMBL
    A0A0G2JXD6
    Conserved Domains (6) summary
    PTZ00121
    Location:2265 → 2570
    PTZ00121; MAEBL; Provisional
    PRK00279
    Location:2203 → 2259
    adk; adenylate kinase; Reviewed
    pfam17380
    Location:2267 → 2414
    DUF5401; Family of unknown function (DUF5401)
    pfam15780
    Location:538 → 637
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
    pfam17213
    Location:2005 → 2229
    Hydin_ADK; Hydin Adenylate kinase-like domain
    cl27657
    Location:227 → 302
    Motile_Sperm; MSP (Major sperm protein) domain

  3. XM_039098234.2 → XP_038954162.1  hydrocephalus-inducing protein homolog isoform X2

    UniProtKB/TrEMBL
    A0A0G2JXD6
    Conserved Domains (6) summary
    PTZ00121
    Location:2304 → 2609
    PTZ00121; MAEBL; Provisional
    PRK00279
    Location:2242 → 2298
    adk; adenylate kinase; Reviewed
    pfam17380
    Location:2306 → 2453
    DUF5401; Family of unknown function (DUF5401)
    pfam15780
    Location:531 → 630
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
    pfam17213
    Location:2044 → 2268
    Hydin_ADK; Hydin Adenylate kinase-like domain
    cl27657
    Location:227 → 302
    Motile_Sperm; MSP (Major sperm protein) domain

  4. XM_039098237.2 → XP_038954165.1  hydrocephalus-inducing protein homolog isoform X4

    UniProtKB/TrEMBL
    A0A0G2JXD6
    Conserved Domains (5) summary
    PRK00279
    Location:2249 → 2305
    adk; adenylate kinase; Reviewed
    pfam17380
    Location:2313 → 2460
    DUF5401; Family of unknown function (DUF5401)
    pfam15780
    Location:538 → 637
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
    pfam17213
    Location:2051 → 2275
    Hydin_ADK; Hydin Adenylate kinase-like domain
    cl27657
    Location:227 → 302
    Motile_Sperm; MSP (Major sperm protein) domain

  5. XM_039098239.2 → XP_038954167.1  hydrocephalus-inducing protein homolog isoform X6

    Conserved Domains (5) summary
    PRK00279
    Location:2249 → 2305
    adk; adenylate kinase; Reviewed
    pfam17380
    Location:2313 → 2460
    DUF5401; Family of unknown function (DUF5401)
    pfam15780
    Location:538 → 637
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
    pfam17213
    Location:2051 → 2275
    Hydin_ADK; Hydin Adenylate kinase-like domain
    cl27657
    Location:227 → 302
    Motile_Sperm; MSP (Major sperm protein) domain

  6. XM_063277933.1 → XP_063134003.1  hydrocephalus-inducing protein homolog isoform X9

  7. XM_063277934.1 → XP_063134004.1  hydrocephalus-inducing protein homolog isoform X10

  8. XM_063277935.1 → XP_063134005.1  hydrocephalus-inducing protein homolog isoform X11

  9. XM_039098238.2 → XP_038954166.1  hydrocephalus-inducing protein homolog isoform X5

    UniProtKB/TrEMBL
    A0A0G2JXD6
    Conserved Domains (3) summary
    PRK00279
    Location:1280 → 1336
    adk; adenylate kinase; Reviewed
    pfam17380
    Location:1344 → 1491
    DUF5401; Family of unknown function (DUF5401)
    pfam17213
    Location:1082 → 1306
    Hydin_ADK; Hydin Adenylate kinase-like domain

  10. XM_039098241.2 → XP_038954169.1  hydrocephalus-inducing protein homolog isoform X7

    Conserved Domains (4) summary
    PTZ00121
    Location:745 → 1050
    PTZ00121; MAEBL; Provisional
    PRK00279
    Location:683 → 739
    adk; adenylate kinase; Reviewed
    pfam17380
    Location:747 → 894
    DUF5401; Family of unknown function (DUF5401)
    pfam17213
    Location:485 → 709
    Hydin_ADK; Hydin Adenylate kinase-like domain

  11. XM_063277932.1 → XP_063134002.1  hydrocephalus-inducing protein homolog isoform X8

Nucleotide Protein Strain
Heading Accession and Version

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