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Aprt adenine phosphoribosyl transferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 292072, updated on 28-Oct-2024

Summary

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Official Symbol
Aprtprovided by RGD
Official Full Name
adenine phosphoribosyl transferaseprovided by RGD
Primary source
RGD:1307758
See related
AllianceGenome:RGD:1307758
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables AMP binding activity. Involved in cellular response to insulin stimulus and lactation. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in adenine phosphoribosyltransferase deficiency. Orthologous to human APRT (adenine phosphoribosyltransferase). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Heart (RPKM 571.1), Lung (RPKM 480.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Aprt in Genome Data Viewer
Location:
19q12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (67534737..67537027, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (50626201..50628491, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (55387288..55389256, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103694354 Neighboring gene chromatin licensing and DNA replication factor 1 Neighboring gene galactosamine (N-acetyl)-6-sulfatase Neighboring gene trafficking protein particle complex subunit 2L

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Purification of adenine phosphoribosyltransferase by affinity chromatography. Hershey HV, et al. Prep Biochem, 1978. PMID 748918
  2. The rat adenine phosphoribosyltransferase sequence shows evolutionary rate variation among exons in rodents. Fieldhouse D, et al. Genome, 1993 Dec. PMID 8112572
  3. Enzymes of the pathway of purine synthesis in the rat mammary gland. Changes in the lactation cycle and the effects of diabetes. Beardsley S, et al. Biochem J, 1988 Mar 1. PMID 2451510, Free PMC Article
  4. Identification of two novel mutations in adenine phosphoribosyltransferase gene in patients with 2,8-dihydroxyadenine urolithiasis. Taniguchi A, et al. Nucleosides Nucleotides Nucleic Acids, 2004 Oct. PMID 15571218
  5. Three-dimensional structure of human adenine phosphoribosyltransferase and its relation to DHA-urolithiasis. Silva M, et al. Biochemistry, 2004 Jun 22. PMID 15196008

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables AMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables AMP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables AMP binding IEA
Inferred from Electronic Annotation
more info
  
enables AMP binding ISO
Inferred from Sequence Orthology
more info
  
enables adenine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenine binding IEA
Inferred from Electronic Annotation
more info
  
enables adenine binding ISO
Inferred from Sequence Orthology
more info
  
enables adenine phosphoribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenine phosphoribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables adenine phosphoribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables adenine phosphoribosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in AMP salvage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in AMP salvage IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within AMP salvage ISO
Inferred from Sequence Orthology
more info
  
involved_in AMP salvage ISO
Inferred from Sequence Orthology
more info
  
involved_in GMP salvage IEA
Inferred from Electronic Annotation
more info
  
involved_in GMP salvage ISO
Inferred from Sequence Orthology
more info
  
involved_in IMP salvage IEA
Inferred from Electronic Annotation
more info
  
involved_in IMP salvage ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within adenine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in adenine salvage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenine salvage IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to insulin stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in grooming behavior IEA
Inferred from Electronic Annotation
more info
  
NOT acts_upstream_of_or_within grooming behavior ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within grooming behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in lactation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in purine ribonucleoside salvage IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within purine ribonucleoside salvage ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
adenine phosphoribosyltransferase
NP_001013079.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013061.2 → NP_001013079.1  adenine phosphoribosyltransferase

    See identical proteins and their annotated locations for NP_001013079.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/Swiss-Prot
    P36972
    UniProtKB/TrEMBL
    A0A8L2QU71, A6IZS8
    Conserved Domains (1) summary
    PRK02304
    Location:6 → 180
    PRK02304; adenine phosphoribosyltransferase; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    67534737..67537027 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36972.1 GenPept UniProtKB/Swiss-Prot:P36972

Gene LinkOut

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