U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Afap1l2 actin filament associated protein 1-like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 292130, updated on 10-Jul-2024

Summary

Go to the top of the page Help
Official Symbol
Afap1l2provided by RGD
Official Full Name
actin filament associated protein 1-like 2provided by RGD
Primary source
RGD:1310668
See related
EnsemblRapid:ENSRNOG00000017164 AllianceGenome:RGD:1310668
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310668
Summary
Predicted to enable SH2 domain binding activity; SH3 domain binding activity; and protein tyrosine kinase activator activity. Predicted to be involved in several processes, including positive regulation of epidermal growth factor receptor signaling pathway; regulation of gene expression; and regulation of mitotic cell cycle. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol. Orthologous to human AFAP1L2 (actin filament associated protein 1 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 87.9), Kidney (RPKM 62.8) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Afap1l2 in Genome Data Viewer
Location:
1q55
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (265969368..266065951, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (255964238..256060828, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (277730760..277827299, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 186 Neighboring gene tudor domain containing 1 Neighboring gene von Willebrand factor A domain containing 2 Neighboring gene actin-binding LIM protein 1 Neighboring gene uncharacterized LOC134485257 Neighboring gene uncharacterized LOC120100065

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Phosphatidylinositol 3-kinase-binding protein, PI3KAP/XB130, is required for cAMP-induced amplification of IGF mitogenic activity in FRTL-5 thyroid cells. Yamanaka D, et al. Mol Endocrinol, 2012 Jun. PMID 22496359, Free PMC Article
  2. Adaptor protein XB130 is a Rac-controlled component of lamellipodia that regulates cell motility and invasion. Lodyga M, et al. J Cell Sci, 2010 Dec 1. PMID 21084565
  3. Estradiol up-regulates L-type Ca(2+) channels via membrane-bound estrogen receptor/phosphoinositide-3-kinase/Akt/cAMP response element-binding protein signaling pathway. Yang X, et al. Heart Rhythm, 2018 May. PMID 29330129
  4. XB130, a novel adaptor protein for signal transduction. Xu J, et al. J Biol Chem, 2007 Jun 1. PMID 17412687
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Estradiol up-regulates Cav1.2alpha1C and ICa,L via plasma membrane ER and by activating Pi3K, Akt, and CREB signaling. The promoter regions of the CACNA1C gene (human-rabbit-rat) contain adjacent/overlapping binding sites for p-CREB and ERalpha, which suggests a synergistic regulation by these pathways.
    Title: Estradiol up-regulates L-type Ca(2+) channels via membrane-bound estrogen receptor/phosphoinositide-3-kinase/Akt/cAMP response element-binding protein signaling pathway.
  2. cAMP-dependent induction of PI3KAP/XB130, which is associated with PI3K, is required for enhancement of IGF mitogenic activities. [PI3KAP]
    Title: Phosphatidylinositol 3-kinase-binding protein, PI3KAP/XB130, is required for cAMP-induced amplification of IGF mitogenic activity in FRTL-5 thyroid cells.
  3. XB130 is a Rac-controlled component of lamellipodia that regulates cell motility and invasion.
    Title: Adaptor protein XB130 is a Rac-controlled component of lamellipodia that regulates cell motility and invasion.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH2 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SH2 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables SH3 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-8 production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of interleukin-6 production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
actin filament-associated protein 1-like 2
Names
phosphatidylinositol 3-kinase-associated protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305184.1 → NP_001292113.1  actin filament-associated protein 1-like 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    F1M5W8, M0R484
    Related
    ENSRNOP00000064164.3, ENSRNOT00000073346.5
    Conserved Domains (3) summary
    cd13306
    Location:184 → 290
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:372 → 472
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:190 → 289
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    265969368..266065951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063282799.1 → XP_063138869.1  actin filament-associated protein 1-like 2 isoform X2

    UniProtKB/TrEMBL
    F1M5W8

  2. XM_008760580.4 → XP_008758802.1  actin filament-associated protein 1-like 2 isoform X1

    See identical proteins and their annotated locations for XP_008758802.1

    UniProtKB/TrEMBL
    F1M5W8
    Conserved Domains (3) summary
    cd13306
    Location:212 → 318
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:400 → 500
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:218 → 317
    PH; PH domain

  3. XM_063282804.1 → XP_063138874.1  actin filament-associated protein 1-like 2 isoform X8

    UniProtKB/TrEMBL
    F1M5W8

  4. XM_063282800.1 → XP_063138870.1  actin filament-associated protein 1-like 2 isoform X4

    UniProtKB/TrEMBL
    F1M5W8

  5. XM_063282803.1 → XP_063138873.1  actin filament-associated protein 1-like 2 isoform X7

    UniProtKB/TrEMBL
    F1M5W8

  6. XM_063282802.1 → XP_063138872.1  actin filament-associated protein 1-like 2 isoform X6

    UniProtKB/TrEMBL
    F1M5W8

  7. XM_017588861.3 → XP_017444350.1  actin filament-associated protein 1-like 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I6ARV2, F1M5W8
    Conserved Domains (3) summary
    cd13306
    Location:212 → 318
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:400 → 500
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:218 → 317
    PH; PH domain

  8. XM_063282801.1 → XP_063138871.1  actin filament-associated protein 1-like 2 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZTP6, F1M5W8
    Related
    ENSRNOP00000097019.2, ENSRNOT00000110011.2

  9. XM_063282805.1 → XP_063138875.1  actin filament-associated protein 1-like 2 isoform X9

    UniProtKB/TrEMBL
    F1M5W8
    Related
    ENSRNOP00000023113.6, ENSRNOT00000023113.9
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools