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Eif3a eukaryotic translation initiation factor 3, subunit A [ Rattus norvegicus (Norway rat) ]

Gene ID: 292148, updated on 14-Nov-2024

Summary

Official Symbol
Eif3aprovided by RGD
Official Full Name
eukaryotic translation initiation factor 3, subunit Aprovided by RGD
Primary source
RGD:1307269
See related
EnsemblRapid:ENSRNOG00000010117 AllianceGenome:RGD:1307269
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ZH12; Eif3s10
Summary
Enables receptor tyrosine kinase binding activity. Involved in negative regulation of ERK1 and ERK2 cascade. Located in microtubule. Orthologous to human EIF3A (eukaryotic translation initiation factor 3 subunit A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 389.0), Spleen (RPKM 371.8) and 9 other tissues See more
Orthologs
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Genomic context

See Eif3a in Genome Data Viewer
Location:
1q55
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (269888730..269925785, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (259902767..259932976, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (282139809..282170017, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485267 Neighboring gene nanos C2HC-type zinc finger 1 Neighboring gene small nucleolar RNA SNORA19 Neighboring gene uncharacterized LOC134485268 Neighboring gene DENN domain containing 10 Neighboring gene sideroflexin 4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to translation initiation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
 
part_of eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
 
part_of eukaryotic translation initiation factor 3 complex IEA
Inferred from Electronic Annotation
more info
 
part_of eukaryotic translation initiation factor 3 complex ISO
Inferred from Sequence Orthology
more info
 
part_of eukaryotic translation initiation factor 3 complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of eukaryotic translation initiation factor 3 complex, eIF3e IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of eukaryotic translation initiation factor 3 complex, eIF3m IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of eukaryotic translation initiation factor 3 complex, eIF3m ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule IDA
Inferred from Direct Assay
more info
PubMed 
part_of multi-eIF complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
eukaryotic translation initiation factor 3 subunit A
Names
eIF-3-theta
eukaryotic translation initiation factor 3 subunit 10
eukaryotic translation initiation factor 3, subunit 10 (theta)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001047087.2NP_001040552.2  eukaryotic translation initiation factor 3 subunit A

    See identical proteins and their annotated locations for NP_001040552.2

    Status: VALIDATED

    Source sequence(s)
    AB259154, CB698626
    UniProtKB/Swiss-Prot
    Q1JU68
    UniProtKB/TrEMBL
    A0A8I6A8S5
    Related
    ENSRNOP00000063484.2, ENSRNOT00000066947.5
    Conserved Domains (5) summary
    smart00753
    Location:426498
    PAM; PCI/PINT associated module
    cd16269
    Location:650661
    GBP_C; coiled coil [structural motif]
    cl19219
    Location:643737
    DUF342; Protein of unknown function (DUF342)
    cl20817
    Location:566685
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21478
    Location:516603
    ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    269888730..269925785 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063282821.1XP_063138891.1  eukaryotic translation initiation factor 3 subunit A isoform X1

    UniProtKB/TrEMBL
    A6JIA5