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Car4 carbonic anhydrase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29242, updated on 10-Jul-2024

Summary

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Official Symbol
Car4provided by RGD
Official Full Name
carbonic anhydrase 4provided by RGD
Primary source
RGD:2242
See related
EnsemblRapid:ENSRNOG00000002916 AllianceGenome:RGD:2242
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ca4
Summary
Enables carbonate dehydratase activity. Involved in animal organ development; response to steroid hormone; and response to xenobiotic stimulus. Located in apical plasma membrane; sarcolemma; and sarcoplasmic reticulum. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human CA4 (carbonic anhydrase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 349.5), Kidney (RPKM 191.9) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Car4 in Genome Data Viewer
Location:
10q26
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (70325102..70333916)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (69827945..69836501)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (72272286..72281069)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene cytochrome c oxidase subunit 7B, pseudogene 4 Neighboring gene ribosomal protein L37A, pseudogene 3 Neighboring gene ubiquitin specific peptidase 32 Neighboring gene DAB adaptor protein 1, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Regression of medial elastocalcinosis in rat aorta: a new vascular function for carbonic anhydrase. Essalihi R, et al. Circulation, 2005 Sep 13. PMID 16144999
  2. Rat embryos express transcripts for cyclooxygenase-1 and carbonic anhydrase-4, but not for cyclooxygenase-2, during organogenesis. Streck RD, et al. Birth Defects Res B Dev Reprod Toxicol, 2003 Feb. PMID 12852484
  3. Regional expression and androgen regulation of carbonic anhydrase IV and II in the adult rat epididymis. Kaunisto K, et al. Biol Reprod, 1999 Dec. PMID 10569998
  4. Membrane-associated carbonic anhydrase IV in skeletal muscle: subcellular localization. Decker B, et al. Histochem Cell Biol, 1996 Oct. PMID 8911968
  5. Pulmonary carbonic anhydrase IV: developmental regulation and cell-specific expression in the capillary endothelium. Fleming RE, et al. Am J Physiol, 1993 Dec. PMID 8279579

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Renal vascular reactivity is associated with up regulation of renal endothelin receptors type A.
    Title: Lipopolysaccharide enhanced renal vascular response to endothelin-1 through ETA overexpression in portal hypertensive rats.
  2. Vascular mineral loss induced by blockade of endothelin receptors seems dependent on activation of membrane-bound carbonic anhydrase IV. Mineral loss may proceed via local changes in pH similar to that seen in bone resorption.
    Title: Regression of medial elastocalcinosis in rat aorta: a new vascular function for carbonic anhydrase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carbonate dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbonate dehydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carbonate dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables carbonate dehydratase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in bicarbonate transport ISO
Inferred from Sequence Orthology
more info
  
involved_in one-carbon metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to steroid hormone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
NOT located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in sarcolemma IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in secretory granule membrane ISO
Inferred from Sequence Orthology
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  
located_in transport vesicle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
carbonic anhydrase 4
Names
CA-IV
carbonate dehydratase IV
carbonic anhydrase IV
NP_062047.1
XP_038941640.1
XP_063124865.1
XP_063124866.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019174.3 → NP_062047.1  carbonic anhydrase 4 precursor

    See identical proteins and their annotated locations for NP_062047.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    P48284, Q4QR97
    UniProtKB/TrEMBL
    A0A0H2UHB3, A6HHN2
    Related
    ENSRNOP00000003908.3, ENSRNOT00000003908.7
    Conserved Domains (1) summary
    cd03117
    Location:47 → 280
    alpha_CA_IV_XV_like; Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    70325102..70333916
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268796.1 → XP_063124866.1  carbonic anhydrase 4 isoform X2

  2. XM_039085712.2 → XP_038941640.1  carbonic anhydrase 4 isoform X1

    Conserved Domains (1) summary
    cl00012
    Location:1 → 190
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

  3. XM_063268795.1 → XP_063124865.1  carbonic anhydrase 4 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48284.1 GenPept UniProtKB/Swiss-Prot:P48284

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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