U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Stx11 syntaxin 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 292483, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
Stx11provided by RGD
Official Full Name
syntaxin 11provided by RGD
Primary source
RGD:1304744
See related
EnsemblRapid:ENSRNOG00000014902 AllianceGenome:RGD:1304744
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to act upstream of or within cellular response to interferon-gamma and leukocyte degranulation. Predicted to be located in phagocytic vesicle. Human ortholog(s) of this gene implicated in familial hemophagocytic lymphohistiocytosis 4. Orthologous to human STX11 (syntaxin 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 72.6), Spleen (RPKM 68.9) and 8 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Stx11 in Genome Data Viewer
Location:
1p13
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (9111216..9140227, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (7293427..7320060, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (7039160..7064870, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene utrophin Neighboring gene uncharacterized LOC134482577 Neighboring gene uncharacterized LOC134482578 Neighboring gene transfer RNA leucine (anticodon UAA) 1 Neighboring gene uncharacterized LOC120098780 Neighboring gene uncharacterized LOC120098781 Neighboring gene uncharacterized LOC134484945 Neighboring gene small nucleolar RNA SNORA48

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Syntaxin 11 is required for NK and CD8⁺ T-cell cytotoxicity and neutrophil degranulation. D'Orlando O, et al. Eur J Immunol, 2013 Jan. PMID 23042080, Free PMC Article
  2. Hemophagocytic lymphohistiocytosis in syntaxin-11-deficient mice: T-cell exhaustion limits fatal disease. Kögl T, et al. Blood, 2013 Jan 24. PMID 23190531
  3. The phagosomal proteome in interferon-gamma-activated macrophages. Trost M, et al. Immunity, 2009 Jan 16. PMID 19144319
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Clone Names

  • MGC116325

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within T cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cytotoxic T cell degranulation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within natural killer cell degranulation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neutrophil degranulation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
syntaxin-11

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025638.3 → NP_001020809.2  syntaxin-11

    See identical proteins and their annotated locations for NP_001020809.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A0G2K516, A6JP51
    Related
    ENSRNOP00000108874.1, ENSRNOT00000124313.1
    Conserved Domains (3) summary
    cd00179
    Location:41 → 193
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    cd15878
    Location:203 → 265
    SNARE_syntaxin11; SNARE motif of syntaxin 11
    pfam00804
    Location:41 → 238
    Syntaxin; Syntaxin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    9111216..9140227 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008758601.3 → XP_008756823.1  syntaxin-11 isoform X1

    See identical proteins and their annotated locations for XP_008756823.1

    UniProtKB/TrEMBL
    A0A0G2K516, A6JP51
    Related
    ENSRNOP00000111679.1, ENSRNOT00000163095.1
    Conserved Domains (3) summary
    cd00179
    Location:41 → 193
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    cd15878
    Location:203 → 265
    SNARE_syntaxin11; SNARE motif of syntaxin 11
    pfam00804
    Location:41 → 238
    Syntaxin; Syntaxin
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials