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Gzmm granzyme M [ Rattus norvegicus (Norway rat) ]

Gene ID: 29252, updated on 10-Jul-2024

Summary

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Official Symbol
Gzmmprovided by RGD
Official Full Name
granzyme Mprovided by RGD
Primary source
RGD:620022
See related
EnsemblRapid:ENSRNOG00000030530 AllianceGenome:RGD:620022
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables serine-type peptidase activity. Predicted to be involved in cell death. Predicted to act upstream of or within T cell mediated cytotoxicity. Predicted to be located in extracellular region. Orthologous to human GZMM (granzyme M). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 191.2), Lung (RPKM 90.7) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gzmm in Genome Data Viewer
Location:
7q11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10661683..10667448, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (10011065..10016841, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12893431..12899004, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 Neighboring gene uncharacterized LOC134479816 Neighboring gene basigin Neighboring gene cell division cycle 34, ubiqiutin conjugating enzyme Neighboring gene tubulin polyglutamylase complex subunit 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Purification and cloning of a novel serine protease, RNK-Met-1, from the granules of a rat natural killer cell leukemia. Smyth MJ, et al. J Biol Chem, 1992 Dec 5. PMID 1447189
  2. Intracellular serine protease inhibitor SERPINB4 inhibits granzyme M-induced cell death. de Koning PJ, et al. PLoS One, 2011. PMID 21857942, Free PMC Article
  3. SPI-CI and SPI-6 cooperate in the protection from effector cell-mediated cytotoxicity. Bots M, et al. Blood, 2005 Feb 1. PMID 15454490
  4. Gene expression profile of the rat eye iridocorneal angle: NEIBank expressed sequence tag analysis. Ahmed F, et al. Invest Ophthalmol Vis Sci, 2004 Sep. PMID 15326124
  5. The sclerostin-bone protein interactome. Devarajan-Ketha H, et al. Biochem Biophys Res Commun, 2012 Jan 13. PMID 22206666, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within T cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in killing of cells of another organism IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
granzyme M
Names
RNK-Met-1
granzyme M (lymphocyte met-ase 1)
lymphoctye Met-ase 1
met-ase
natural killer cell granular protease

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_057183.1 → NP_476531.1  granzyme M precursor

    See identical proteins and their annotated locations for NP_476531.1

    Status: VALIDATED

    Source sequence(s)
    BI278865, DV216119
    UniProtKB/Swiss-Prot
    Q03238
    UniProtKB/TrEMBL
    A6K8Y7, G3V726
    Related
    ENSRNOP00000083530.1, ENSRNOT00000095743.2
    Conserved Domains (1) summary
    cd00190
    Location:27 → 254
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    10661683..10667448 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263113.1 → XP_063119183.1  granzyme M isoform X1

  2. XM_039078568.2 → XP_038934496.1  granzyme M isoform X2

    UniProtKB/Swiss-Prot
    Q03238
    Related
    ENSRNOP00000011086.4, ENSRNOT00000011086.8
    Conserved Domains (1) summary
    cd00190
    Location:26 → 253
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  3. XM_039078569.2 → XP_038934497.1  granzyme M isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZVJ4
    Conserved Domains (1) summary
    cd00190
    Location:1 → 214
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03238.1 GenPept UniProtKB/Swiss-Prot:Q03238

Gene LinkOut

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