Zfp418 zinc finger protein 418 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zfp418provided by RGD
Official Full Name: zinc finger protein 418provided by RGD
Primary source: RGD:1311663
See related: EnsemblRapid:ENSRNOG00000015271 AllianceGenome:RGD:1311663
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ZNF418; RGD1311663
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in microautophagy and regulation of proteasomal ubiquitin-dependent protein catabolic process. Is active in nucleus. Orthologous to human ZNF416 (zinc finger protein 416). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 41.0), Brain (RPKM 38.9) and 9 other tissues See more
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Genomic context

Location:: 1q12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (75614531..75627367)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (66581406..66594247)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (69615413..69629997)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH131093 (e-PCR)
- UniSTS:214376

RH130850 (e-PCR)
- UniSTS:214134

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in microautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microautophagy	ISO Inferred from Sequence Orthology more info
involved_in microautophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: zinc finger protein 418

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191620.1 → NP_001178549.1 zinc finger protein 418

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A0G2K5M4

Related

ENSRNOP00000020751.9, ENSRNOT00000020751.9

Conserved Domains (5) summary

smart00349
Location:25 → 66

KRAB; krueppel associated box

COG5048
Location:290 → 647

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:574 → 594

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01352
Location:25 → 64

KRAB; KRAB box

pfam13465
Location:614 → 639

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

75614531..75627367

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006228177.5 → XP_006228239.1 zinc finger protein 418 isoform X1

UniProtKB/TrEMBL

A0A0G2K5M4

Conserved Domains (5) summary

smart00349
Location:35 → 76

KRAB; krueppel associated box

COG5048
Location:300 → 657

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:584 → 604

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01352
Location:35 → 74

KRAB; KRAB box

pfam13465
Location:624 → 649

zf-H2C2_2; Zinc-finger double domain
XM_039103765.2 → XP_038959693.1 zinc finger protein 418 isoform X2

Conserved Domains (3) summary

COG5048
Location:286 → 643

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:570 → 590

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01352
Location:32 → 60

KRAB; KRAB box