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Lilrb4 leukocyte immunoglobulin like receptor B4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 292594, updated on 17-Aug-2024

Summary

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Official Symbol
Lilrb4provided by RGD
Official Full Name
leukocyte immunoglobulin like receptor B4provided by RGD
Primary source
RGD:1359090
See related
EnsemblRapid:ENSRNOG00000027811 AllianceGenome:RGD:1359090
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gp49b; GP49B2
Summary
Predicted to enable protein phosphatase binding activity and transmembrane receptor protein tyrosine kinase inhibitor activity. Predicted to be involved in several processes, including negative regulation of cytokine production; regulation of leukocyte activation; and regulation of signal transduction. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Orthologous to human LILRB4 (leukocyte immunoglobulin like receptor B4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 129.2), Kidney (RPKM 103.1) and 8 other tissues See more
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Genomic context

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Location:
1q12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (78847685..78853294, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (69805020..69810628, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (73393854..73399448, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1 Neighboring gene motile sperm domain containing 1, pseudogene 1 Neighboring gene leukocyte immunoglobulin like receptor B4, pseudogene 1 Neighboring gene leukocyte immunoglobulin like receptor B3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The rat orthologue to the inhibitory receptor gp49B is expressed by neutrophils and monocytes, but not by NK cells or mast cells. Bryceson YT, et al. Eur J Immunol, 2005 Apr. PMID 15756648
  2. Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development. Mori Y, et al. J Immunol, 2008 Oct 1. PMID 18802077
  3. Downregulation of inflammatory microRNAs by Ig-like transcript 3 is essential for the differentiation of human CD8(+) T suppressor cells. Chang CC, et al. J Immunol, 2012 Apr 1. PMID 22387553
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lilrb4 ameliorates ileal injury in rats with hemorrhagic shock and suppresses the activation of NF-kappaB signaling pathway.
    Title: Lilrb4 ameliorates ileal injury in rats with hemorrhagic shock and suppresses the activation of NF-κB signaling pathway.
  2. Compared to mouse, the cytoplasmic domain of rat gp49B contains a third ITIM-like sequence
    Title: The rat orthologue to the inhibitory receptor gp49B is expressed by neutrophils and monocytes, but not by NK cells or mast cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables apolipoprotein binding ISO
Inferred from Sequence Orthology
more info
  
enables fibronectin binding ISO
Inferred from Sequence Orthology
more info
  
enables inhibitory MHC class I receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane receptor protein tyrosine kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Fc receptor mediated inhibitory signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response-regulating signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interleukin-10-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in mast cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of IP-10 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of T cell costimulation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of T cell cytokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cytotoxic T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-5 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of monocyte activation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of CD8-positive, alpha-beta T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell anergy ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
  
involved_in tolerance induction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
leukocyte immunoglobulin like receptor B4
Names
glycoprotein 49b
leukocyte immunoglobulin-like receptor, subfamily B, member 4
leukocyte surface receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013894.2 → NP_001013916.1  leukocyte immunoglobulin like receptor B4 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001013916.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A0G2JVH3, E9PTH5, Q67EV2
    Related
    ENSRNOP00000030632.5, ENSRNOT00000038898.6
    Conserved Domains (1) summary
    cl11960
    Location:124 → 218
    Ig; Immunoglobulin domain

  2. NM_001419406.1 → NP_001406335.1  leukocyte immunoglobulin like receptor B4 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A0G2JVH3, Q67EV3
    Related
    ENSRNOP00000069484.1, ENSRNOT00000077186.3

  3. NM_001419407.1 → NP_001406336.1  leukocyte immunoglobulin like receptor B4 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6A469, A0A8I6GJM6
    Related
    ENSRNOP00000092281.1, ENSRNOT00000110970.2

  4. NM_001419408.1 → NP_001406337.1  leukocyte immunoglobulin like receptor B4 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6A0J7
    Related
    ENSRNOP00000083730.1, ENSRNOT00000098988.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    78847685..78853294 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103862.2 → XP_038959790.1  leukocyte immunoglobulin like receptor B4 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A0J7
    Conserved Domains (2) summary
    cd00096
    Location:29 → 33
    Ig; Ig strand A [structural motif]
    cl11960
    Location:29 → 123
    Ig; Immunoglobulin domain

  2. XM_039103861.2 → XP_038959789.1  leukocyte immunoglobulin like receptor B4 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A095, A0A8I6A469
    Related
    ENSRNOP00000083948.1, ENSRNOT00000095592.2
    Conserved Domains (3) summary
    cd00096
    Location:124 → 128
    Ig; Ig strand A [structural motif]
    cd16843
    Location:28 → 116
    IgC2_D1_D2_LILR_KIR_like; Immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
    cl11960
    Location:124 → 218
    Ig; Immunoglobulin domain

  3. XM_063283034.1 → XP_063139104.1  leukocyte immunoglobulin like receptor B4 isoform X6

  4. XM_063283032.1 → XP_063139102.1  leukocyte immunoglobulin like receptor B4 isoform X5

  5. XM_063283021.1 → XP_063139091.1  leukocyte immunoglobulin like receptor B4 isoform X1

    Related
    ENSRNOP00000087354.2, ENSRNOT00000109192.2

  6. XM_063283028.1 → XP_063139098.1  leukocyte immunoglobulin like receptor B4 isoform X4

RNA

  1. XR_010064555.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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