U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Apoc2 apolipoprotein C2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 292697, updated on 17-Aug-2024

Summary

Official Symbol
Apoc2provided by RGD
Official Full Name
apolipoprotein C2provided by RGD
Primary source
RGD:2135
See related
AllianceGenome:RGD:2135
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Apo-CII; ApoC-II; RGD1560725
Summary
Predicted to enable several functions, including identical protein binding activity; lipase activator activity; and phospholipase binding activity. Involved in lipoprotein transport and response to xenobiotic stimulus. Predicted to be located in extracellular space. Predicted to be part of several cellular components, including low-density lipoprotein particle; spherical high-density lipoprotein particle; and triglyceride-rich plasma lipoprotein particle. Human ortholog(s) of this gene implicated in familial apolipoprotein C-II deficiency; familial hyperlipidemia; and multiple sclerosis. Orthologous to human APOC2 (apolipoprotein C2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 6966.8) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Apoc2 in Genome Data Viewer
Location:
1q21
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (88457397..88462365, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (79329429..79334397, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (80589023..80593991, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene RELB proto-oncogene, NF-kB subunit Neighboring gene CLPTM1 regulator of GABA type A receptor forward trafficking Neighboring gene uncharacterized LOC134482894 Neighboring gene apolipoprotein C4 Neighboring gene apolipoprotein C1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme activator activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lipase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding ISO
Inferred from Sequence Orthology
more info
 
enables lipoprotein lipase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables molecular function activator activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phospholipase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phospholipase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
involved_in chylomicron remnant clearance ISO
Inferred from Sequence Orthology
more info
 
involved_in high-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in lipoprotein transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of very-low-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipid efflux ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lipoprotein lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of phospholipase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of phospholipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of phospholipid catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of triglyceride catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in triglyceride homeostasis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of chylomicron IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of chylomicron IEA
Inferred from Electronic Annotation
more info
 
part_of chylomicron ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of high-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 
part_of intermediate-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
part_of low-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 
part_of low-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
part_of spherical high-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
part_of very-low-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 
part_of very-low-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085352.1NP_001078821.1  apolipoprotein C-II precursor

    See identical proteins and their annotated locations for NP_001078821.1

    Status: VALIDATED

    Source sequence(s)
    AA819259, BM385272, CO574111
    UniProtKB/Swiss-Prot
    G3V8D4
    Conserved Domains (1) summary
    pfam05355
    Location:2197
    Apo-CII; Apolipoprotein C-II

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    88457397..88462365 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)