Spr sepiapterin reductase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sprprovided by RGD
Official Full Name: sepiapterin reductaseprovided by RGD
Primary source: RGD:3753
See related: EnsemblRapid:ENSRNOG00000015455 AllianceGenome:RGD:3753
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables sepiapterin reductase (NADP+) activity. Involved in positive regulation of cell population proliferation and tetrahydrobiopterin biosynthetic process. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Human ortholog(s) of this gene implicated in dystonia and sepiapterin reductase deficiency. Orthologous to human SPR (sepiapterin reductase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 299.0), Liver (RPKM 294.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (119229447..119233320, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (117671948..117676292, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (116912343..116916073, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ninety-six-hour starved peripheral blood mononuclear cell supernatant inhibited LA7 breast cancer stem cells induced tumor via reduction in angiogenesis and alternations in Gch1 and Spr expressions.
Title: Ninety-six-hour starved peripheral blood mononuclear cell supernatant inhibited LA7 breast cancer stem cells induced tumor via reduction in angiogenesis and alternations in Gch1 and Spr expressions.

Submit: New GeneRIF Correction

General gene information

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Markers

AA926099 (e-PCR)
- UniSTS:248663

Spr (e-PCR), detects polymorphism
- UniSTS:144504

RH140538 (e-PCR)
- UniSTS:222607

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables sepiapterin reductase (NADP+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables sepiapterin reductase (NADP+) activity	IDA Inferred from Direct Assay more info	PubMed
enables sepiapterin reductase (NADP+) activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within L-phenylalanine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell morphogenesis involved in neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dopamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within norepinephrine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pteridine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within serotonin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in tetrahydrobiopterin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in tetrahydrobiopterin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tetrahydrobiopterin biosynthetic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within tetrahydrobiopterin metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within voluntary musculoskeletal movement	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sepiapterin reductase

Names: sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)

NP_062054.1

EC 1.1.1.153

XP_038963128.1

EC 1.1.1.153

XP_038963129.1

EC 1.1.1.153

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019181.2 → NP_062054.1 sepiapterin reductase

See identical proteins and their annotated locations for NP_062054.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

P18297

UniProtKB/TrEMBL

A0A8I5ZU80, B2RYK3

Related

ENSRNOP00000020749.4, ENSRNOT00000020749.8

Conserved Domains (1) summary

cl21454
Location:9 → 261

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

119229447..119233320 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107201.2 → XP_038963129.1 sepiapterin reductase isoform X2

Conserved Domains (1) summary

cl21454
Location:1 → 130

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_039107200.2 → XP_038963128.1 sepiapterin reductase isoform X1

Conserved Domains (1) summary

cl21454
Location:9 → 164

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins