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Numbl NUMB-like, endocytic adaptor protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 292732, updated on 10-Jul-2024

Summary

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Official Symbol
Numblprovided by RGD
Official Full Name
NUMB-like, endocytic adaptor proteinprovided by RGD
Primary source
RGD:1307579
See related
EnsemblRapid:ENSRNOG00000020867 AllianceGenome:RGD:1307579
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Involved in positive regulation of dendrite morphogenesis. Predicted to be active in cytoplasm. Orthologous to human NUMBL (NUMB like endocytic adaptor protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 44.0), Uterus (RPKM 30.8) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Numbl in Genome Data Viewer
Location:
1q21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (91677437..91701415)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (82549814..82573788)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (84067841..84091659)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene inositol-trisphosphate 3-kinase C Neighboring gene coenzyme Q8B Neighboring gene ribosomal protein L14, pseudogene 3 Neighboring gene uncharacterized LOC120099779 Neighboring gene small nuclear ribonucleoprotein G-like Neighboring gene latent transforming growth factor beta binding protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Dynamic change of Numbl expression after sciatic nerve crush and its role in Schwann cell differentiation. Zhu L, et al. J Neurosci Res, 2012 Aug. PMID 22437994
  2. Expression of Numb and Numb-like in the development of mammalian auditory sensory epithelium. Gao Z, et al. Neuroreport, 2011 Jan 26. PMID 21150807
  3. Phosphorylation of Numb family proteins. Possible involvement of Ca2+/calmodulin-dependent protein kinases. Tokumitsu H, et al. J Biol Chem, 2005 Oct 21. PMID 16105844
  4. NUMBL interacts with TRAF6 and promotes the degradation of TRAF6. Zhou L, et al. Biochem Biophys Res Commun, 2010 Feb 12. PMID 20079715
  5. Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. Pece S, et al. J Cell Biol, 2004 Oct 25. PMID 15492044, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. peripheral nerve injury induced a downregulation of Numbl in the sciatic nerve, which was associated with Schwann cell differentiation.
    Title: Dynamic change of Numbl expression after sciatic nerve crush and its role in Schwann cell differentiation.
  2. We show that NUMBL is expressed in the rat auditory sensory epithelium during cochlear development
    Title: Expression of Numb and Numb-like in the development of mammalian auditory sensory epithelium.
  3. Numb and Numbl may be intracellular targets for CaM-Ks, and they may also be regulated by phosphorylation-dependent interaction with 14-3-3 protein
    Title: Phosphorylation of Numb family proteins. Possible involvement of Ca2+/calmodulin-dependent protein kinases.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in adherens junction organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within adherens junction organization ISO
Inferred from Sequence Orthology
more info
  
involved_in axonogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within axonogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cytokine-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within forebrain development ISO
Inferred from Sequence Orthology
more info
  
involved_in lateral ventricle development IEA
Inferred from Electronic Annotation
more info
  
involved_in lateral ventricle development ISO
Inferred from Sequence Orthology
more info
  
involved_in lateral ventricle development ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within nervous system development ISO
Inferred from Sequence Orthology
more info
  
involved_in neuroblast division in subventricular zone IEA
Inferred from Electronic Annotation
more info
  
involved_in neuroblast division in subventricular zone ISO
Inferred from Sequence Orthology
more info
  
involved_in neuroblast division in subventricular zone ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within neuroblast proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of neurogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neurogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of postsynapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
numb-like protein
Names
numb homolog-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033888.2 → NP_001029060.2  numb-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    Q3MUI2
    Conserved Domains (3) summary
    PHA03247
    Location:262 → 599
    PHA03247; large tegument protein UL36; Provisional
    cd01268
    Location:64 → 198
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:288 → 370
    NumbF; NUMB domain

  2. NM_001398697.1 → NP_001385626.1  numb-like protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    A1L1I3
    UniProtKB/TrEMBL
    Q3MUI2
    Related
    ENSRNOP00000054039.3, ENSRNOT00000057213.5
    Conserved Domains (3) summary
    PHA03247
    Location:259 → 600
    PHA03247; large tegument protein UL36; Provisional
    cd01268
    Location:64 → 198
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:289 → 371
    NumbF; NUMB domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    91677437..91701415
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104071.2 → XP_038959999.1  numb-like protein isoform X3

    UniProtKB/TrEMBL
    Q3MUI2
    Conserved Domains (3) summary
    PHA03247
    Location:218 → 559
    PHA03247; large tegument protein UL36; Provisional
    cd01268
    Location:23 → 157
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:248 → 330
    NumbF; NUMB domain

  2. XM_006228566.5 → XP_006228628.1  numb-like protein isoform X2

    UniProtKB/TrEMBL
    Q3MUI2
    Conserved Domains (2) summary
    cd01268
    Location:91 → 225
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:313 → 397
    NumbF; NUMB domain

  3. XM_006228565.5 → XP_006228627.1  numb-like protein isoform X1

    UniProtKB/TrEMBL
    A0A0G2K9C5, Q3MUI2
    Conserved Domains (2) summary
    cd01268
    Location:91 → 225
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:314 → 398
    NumbF; NUMB domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1L1I3.1 GenPept UniProtKB/Swiss-Prot:A1L1I3

Gene LinkOut

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