Pak4 p21 (RAC1) activated kinase 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pak4provided by RGD
Official Full Name: p21 (RAC1) activated kinase 4provided by RGD
Primary source: RGD:1307705
See related: EnsemblRapid:ENSRNOG00000019883 AllianceGenome:RGD:1307705
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including negative regulation of endothelial cell apoptotic process; positive regulation of angiogenesis; and regulation of MAPK cascade. Predicted to act upstream of or within cellular response to organic cyclic compound and dendritic spine development. Predicted to be active in cytoplasm. Orthologous to human PAK4 (p21 (RAC1) activated kinase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 45.3), Adrenal (RPKM 43.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (92977437..93016721, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (83849904..83889188, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (85162462..85201746)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In pancreatic acinar cells, activation of focal adhesion kinases (p125(FAK),PYK2) and its accompanying adapter proteins, p130CAS/paxillin; Mek1/2, p44/42, GSK3, and beta-catenin are mediated by PAK4.
Title: Group II p21-activated kinase, PAK4, is needed for activation of focal adhesion kinases, MAPK, GSK3, and β-catenin in rat pancreatic acinar cells.
In summary, PAK4 is a key regulator in the pathophysiological process of acute lung injury (ALI) and can be a useful target for ALI treatment.
Title: Simvastatin Ameliorates PAK4 Inhibitor-Induced Gut and Lung Injury.
PAK4 activity was markedly decreased in postmortem brain tissue from Parkinson's disease (PD) patients and in rodent models of PD. Expression of constitutively active PAK4(S445N/S474E) (caPAK4) protected DA neurons in both the 6-hydroxydopamine and alpha-synuclein rat models of PD and preserved motor function.
Title: Nigral dopaminergic PAK4 prevents neurodegeneration in rat models of Parkinson's disease.

Submit: New GeneRIF Correction

General gene information

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Markers

MARC_20651-20652:1024691026:1 (e-PCR)
- UniSTS:268460

AI030619 (e-PCR)
- UniSTS:243431

Pak4 (e-PCR), detects polymorphism
- UniSTS:507113

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine/threonine-protein kinase PAK 4

Names: p21 (CDKN1A)-activated kinase 4; p21 protein (Cdc42/Rac)-activated kinase 4; p21-activated kinase 4

NP_001099708.1

EC 2.7.11.1

XP_063139397.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106238.1 → NP_001099708.1 serine/threonine-protein kinase PAK 4

See identical proteins and their annotated locations for NP_001099708.1

Status: PROVISIONAL

Source sequence(s)

CH473979

UniProtKB/TrEMBL

B5DF62, F7FL63

Related

ENSRNOP00000026966.5, ENSRNOT00000026966.8

Conserved Domains (2) summary

cd01093
Location:10 → 48

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

cl21453
Location:302 → 593

PKc_like; Protein Kinases, catalytic domain