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Csrp1 cysteine and glycine-rich protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29276, updated on 2-Nov-2024

Summary

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Official Symbol
Csrp1provided by RGD
Official Full Name
cysteine and glycine-rich protein 1provided by RGD
Primary source
RGD:62053
See related
EnsemblRapid:ENSRNOG00000008937 AllianceGenome:RGD:62053
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Csrp
Summary
Predicted to enable actinin binding activity. Predicted to be a structural constituent of muscle. Predicted to be involved in muscle tissue development; platelet aggregation; and sarcomere organization. Predicted to be active in Z disc and nucleus. Orthologous to human CSRP1 (cysteine and glycine rich protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 2486.7), Uterus (RPKM 1310.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Csrp1 in Genome Data Viewer
Location:
13q13
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (49709928..49731141)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (47158171..47179388)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (52553843..52575054)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene neuron navigator 1 Neighboring gene uncharacterized LOC120096254 Neighboring gene uncharacterized LOC102553722 Neighboring gene ribosomal protein L11, pseudogene 12 Neighboring gene uncharacterized LOC134481563 Neighboring gene pleckstrin homology-like domain, family A, member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Isolation and developmental expression of a rat cDNA encoding a cysteine-rich zinc finger protein. McLaughlin CR, et al. Nucleic Acids Res, 1994 Dec 11. PMID 7816640, Free PMC Article
  2. cDNA cloning of the basement membrane chondroitin sulfate proteoglycan core protein, bamacan: a five domain structure including coiled-coil motifs. Wu RR, et al. J Cell Biol, 1997 Jan 27. PMID 9015313, Free PMC Article
  3. Analysis of the human cysteine-rich protein gene (CSRP), assignment to chromosome 1q24-1q32, and identification of an associated MspI polymorphism. Wang X, et al. Genomics, 1992 Oct. PMID 1385304
  4. Mutations in Subunits of the Activating Signal Cointegrator 1 Complex Are Associated with Prenatal Spinal Muscular Atrophy and Congenital Bone Fractures. Knierim E, et al. Am J Hum Genet, 2016 Mar 3. PMID 26924529, Free PMC Article
  5. Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes. Fröbel J, et al. Mol Cell Proteomics, 2013 May. PMID 23382103, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actinin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of muscle IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in muscle tissue development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nervous system development NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in platelet aggregation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cysteine and glycine-rich protein 1
Names
CRP
CRP1
Csrp 1
cysteine rich protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017148.2 → NP_058844.1  cysteine and glycine-rich protein 1

    See identical proteins and their annotated locations for NP_058844.1

    Status: PROVISIONAL

    Source sequence(s)
    BC062407
    UniProtKB/Swiss-Prot
    P47875
    UniProtKB/TrEMBL
    A0A8L2Q5C4, A6ICG1
    Related
    ENSRNOP00000011991.5, ENSRNOT00000011991.7
    Conserved Domains (2) summary
    cd09403
    Location:119 → 172
    LIM2_CRP; The second LIM domain of Cysteine Rich Protein (CRP)
    cd09479
    Location:8 → 63
    LIM1_CRP1; The first LIM domain of Cysteine Rich Protein 1 (CRP1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    49709928..49731141
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47875.2 GenPept UniProtKB/Swiss-Prot:P47875

Gene LinkOut

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