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Lasp1 LIM and SH3 protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29278, updated on 10-Jul-2024

Summary

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Official Symbol
Lasp1provided by RGD
Official Full Name
LIM and SH3 protein 1provided by RGD
Primary source
RGD:68408
See related
EnsemblRapid:ENSRNOG00000004132 AllianceGenome:RGD:68408
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables ion transmembrane transporter activity. Involved in ion transport. Located in cortical actin cytoskeleton. Orthologous to human LASP1 (LIM and SH3 protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 384.6), Lung (RPKM 305.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lasp1 in Genome Data Viewer
Location:
10q31
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (83290820..83331989)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (82795177..82835659)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (85744662..85785130)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene transfer RNA cysteine (anticodon GCA) 34 Neighboring gene transfer RNA cysteine (anticodon GCA) 35 Neighboring gene F-box protein 47 Neighboring gene U7 small nuclear RNA Neighboring gene plexin domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Actin-binding proteins in a postsynaptic preparation: Lasp-1 is a component of central nervous system synapses and dendritic spines. Phillips GR, et al. J Neurosci Res, 2004 Oct 1. PMID 15372503
  2. The LIM and SH3 domain-containing protein, lasp-1, may link the cAMP signaling pathway with dynamic membrane restructuring activities in ion transporting epithelia. Chew CS, et al. J Cell Sci, 2000 Jun. PMID 10806114
  3. LIM and SH3 protein 1 localizes to the leading edge of protruding lamellipodia and regulates axon development. Pollitt SL, et al. Mol Biol Cell, 2020 Nov 15. PMID 32997597, Free PMC Article
  4. Change in distribution of cytoskeleton-associated proteins, lasp-1 and palladin, during uterine receptivity in the rat endometrium. Nicholson L, et al. Reprod Fertil Dev, 2018 Oct. PMID 29739492
  5. Lasp-1 regulates podosome function. Stölting M, et al. PLoS One, 2012. PMID 22514729, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Up-regulated microRNA-218-5p ameliorates the damage of dopaminergic neurons in rats with Parkinson's disease via suppression of LASP1.
    Title: Up-regulated microRNA-218-5p ameliorates the damage of dopaminergic neurons in rats with Parkinson's disease via suppression of LASP1.
  2. LIM and SH3 protein 1 localizes to the leading edge of protruding lamellipodia and regulates axon development.
    Title: LIM and SH3 protein 1 localizes to the leading edge of protruding lamellipodia and regulates axon development.
  3. Lasp-1 was increased in the uterus at the time of implantation compared with the time of fertilization.
    Title: Change in distribution of cytoskeleton-associated proteins, lasp-1 and palladin, during uterine receptivity in the rat endometrium.
  4. Data indicate that Lasp-1 is a novel component of podosomes and is involved in the regulation of podosomal function.
    Title: Lasp-1 regulates podosome function.
  5. binding sites necessary for Krp1-Lasp1 interaction in vitro and function in vivo
    Title: Novel beta-propeller of the BTB-Kelch protein Krp1 provides a binding site for Lasp-1 that is necessary for pseudopodial extension.
  6. Lasp-1 is strongly expressed by central nervous system neurons and is concentrated at synaptic sites.
    Title: Actin-binding proteins in a postsynaptic preparation: Lasp-1 is a component of central nervous system synapses and dendritic spines.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
LIM and SH3 domain protein 1
Names
LASP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032613.3 → NP_116002.1  LIM and SH3 domain protein 1

    See identical proteins and their annotated locations for NP_116002.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q499R9, Q99MZ8
    UniProtKB/TrEMBL
    A0A8I6G1X8, A6HIN2
    Related
    ENSRNOP00000005522.6, ENSRNOT00000005522.10
    Conserved Domains (3) summary
    smart00227
    Location:98 → 128
    NEBU; The Nebulin repeat is present also in Las1
    cd09447
    Location:5 → 57
    LIM_LASP; The LIM domain of LIM and SH3 Protein (LASP)
    cd11934
    Location:205 → 263
    SH3_Lasp1_C; C-terminal Src Homology 3 domain of LIM and SH3 domain protein 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    83290820..83331989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268798.1 → XP_063124868.1  LIM and SH3 domain protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q499R9, Q99MZ8
    UniProtKB/TrEMBL
    A0A8I6G1X8, A6HIN2
    Related
    ENSRNOP00000098308.2, ENSRNOT00000120676.2

  2. XM_006247288.5 → XP_006247350.1  LIM and SH3 domain protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6G1X8
    Conserved Domains (3) summary
    smart00227
    Location:62 → 92
    NEBU; The Nebulin repeat is present also in Las1
    cd11934
    Location:169 → 227
    SH3_Lasp1_C; C-terminal Src Homology 3 domain of LIM and SH3 domain protein 1
    cl02475
    Location:1 → 21
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  3. XM_063268799.1 → XP_063124869.1  LIM and SH3 domain protein 1 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99MZ8.1 GenPept UniProtKB/Swiss-Prot:Q99MZ8

Gene LinkOut

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