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Sbsn suprabasin [ Rattus norvegicus (Norway rat) ]

Gene ID: 292793, updated on 2-Nov-2024

Summary

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Official Symbol
Sbsnprovided by RGD
Official Full Name
suprabasinprovided by RGD
Primary source
RGD:1562305
See related
EnsemblRapid:ENSRNOG00000021015 AllianceGenome:RGD:1562305
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562305
Summary
Predicted to be located in cytoplasm. Orthologous to human SBSN (suprabasin). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 59.3), Adrenal (RPKM 28.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sbsn in Genome Data Viewer
Location:
1q21
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (95106390..95133448)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (85978970..86006034)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (89202527..89206994)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ATPase H+/K+ transporting subunit alpha Neighboring gene transmembrane protein 147 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase, spermatogenic Neighboring gene dermokine Neighboring gene keratinocyte differentiation associated protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Suprabasin, a novel epidermal differentiation marker and potential cornified envelope precursor. Park GT, et al. J Biol Chem, 2002 Nov 22. PMID 12228223, Free PMC Article
  2. SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers. Zanivan S, et al. Mol Cell Proteomics, 2013 Dec. PMID 23979707, Free PMC Article
  3. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC125085

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
suprabasin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044231.2 → NP_001037696.1  suprabasin isoform 2 precursor

    See identical proteins and their annotated locations for NP_001037696.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splicing site in the CDS, as compared to variant 1. The resulting isoform (2) is much shorter and lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    BC107924, CV112367, JAXUCZ010000001
    UniProtKB/TrEMBL
    Q32PY8

  2. NM_001198590.1 → NP_001185519.1  suprabasin isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    F7FEM5
    Related
    ENSRNOP00000084464.2, ENSRNOT00000111530.2
    Conserved Domains (1) summary
    NF033849
    Location:138 → 418
    ser_rich_anae_1; serine-rich protein

  3. NM_001198591.1 → NP_001185520.1  suprabasin isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate splicing site in the CDS, as compared to variant 1. The resulting isoform (3) is much shorter and lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    BC157808, JAXUCZ010000001

RNA

  1. NR_177078.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate upstream promoter compared to variants 1-3 and is predicted to be non-coding.
    Source sequence(s)
    JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    95106390..95133448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104509.2 → XP_038960437.1  suprabasin isoform X3

    UniProtKB/TrEMBL
    Q32PY8

  2. XM_063283652.1 → XP_063139722.1  suprabasin isoform X1

    Related
    ENSRNOP00000099167.1, ENSRNOT00000133127.1

  3. XM_063283656.1 → XP_063139726.1  suprabasin isoform X2

    UniProtKB/TrEMBL
    F7FEM5

  4. XM_063283654.1 → XP_063139724.1  suprabasin isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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