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Josd2 Josephin domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 292876, updated on 17-Aug-2024

Summary

Official Symbol
Josd2provided by RGD
Official Full Name
Josephin domain containing 2provided by RGD
Primary source
RGD:1307305
See related
EnsemblRapid:ENSRNOG00000019442 AllianceGenome:RGD:1307305
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307305
Summary
Predicted to enable thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination. Orthologous to human JOSD2 (Josephin domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 114.2), Brain (RPKM 88.7) and 9 other tissues See more
Orthologs
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Genomic context

Location:
1q22
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104097382..104101271)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (94960867..94964751)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (100473426..100477352)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108349570 Neighboring gene leucine rich repeat containing 4B Neighboring gene aspartate dehydrogenase domain containing Neighboring gene transfer RNA alanine (anticodon AGC) 69 Neighboring gene ER membrane protein complex subunit 10

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
josephin-2
Names
Josephin-2
NP_001099726.2
XP_006229058.1
XP_006229059.1
XP_006229060.1
XP_038960714.1
XP_038960715.1
XP_063139996.1
XP_063139998.1
XP_063140001.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106256.2NP_001099726.2  josephin-2

    See identical proteins and their annotated locations for NP_001099726.2

    Status: PROVISIONAL

    Source sequence(s)
    CK842299, DV214517
    UniProtKB/TrEMBL
    A6JAP3
    Conserved Domains (1) summary
    pfam02099
    Location:19166
    Josephin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    104097382..104101271
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006228996.5XP_006229058.1  josephin-2 isoform X1

    UniProtKB/TrEMBL
    D4AD44
    Related
    ENSRNOP00000026379.5, ENSRNOT00000026379.7
    Conserved Domains (1) summary
    pfam02099
    Location:58205
    Josephin; Josephin
  2. XM_006228997.5XP_006229059.1  josephin-2 isoform X2

    Conserved Domains (1) summary
    pfam02099
    Location:57204
    Josephin; Josephin
  3. XM_039104786.2XP_038960714.1  josephin-2 isoform X4

    Conserved Domains (1) summary
    pfam02099
    Location:58163
    Josephin
  4. XM_063283926.1XP_063139996.1  josephin-2 isoform X5

  5. XM_063283931.1XP_063140001.1  josephin-2 isoform X6

    UniProtKB/TrEMBL
    A0A8I6GJF0
    Related
    ENSRNOP00000091200.1, ENSRNOT00000118261.2
  6. XM_063283928.1XP_063139998.1  josephin-2 isoform X6

    UniProtKB/TrEMBL
    A0A8I6GJF0
  7. XM_006228998.5XP_006229060.1  josephin-2 isoform X3

    See identical proteins and their annotated locations for XP_006229060.1

    UniProtKB/TrEMBL
    A6JAP3
    Conserved Domains (1) summary
    pfam02099
    Location:19166
    Josephin
  8. XM_039104787.2XP_038960715.1  josephin-2 isoform X7

    UniProtKB/TrEMBL
    A6JAP7
    Conserved Domains (1) summary
    pfam02099
    Location:293
    Josephin