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Reps1 RALBP1 associated Eps domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 292944, updated on 10-Oct-2024

Summary

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Symbol
Reps1provided by RGD
Full Name
RALBP1 associated Eps domain containing 1provided by RGD
Primary source
RGD:1307131
See related
EnsemblRapid:ENSRNOG00000059224 AllianceGenome:RGD:1307131
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable SH3 domain binding activity. Predicted to be involved in endocytosis and endosomal transport. Predicted to be located in clathrin-coated pit. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation. Orthologous to human REPS1 (RALBP1 associated Eps domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 150.6), Spleen (RPKM 82.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Reps1 in Genome Data Viewer
Location:
1p12
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (14517589..14595404)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (12697742..12775562)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (13262049..13298347)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene hdc homolog, cell cycle regulator Neighboring gene ABRA C-terminal like Neighboring gene epithelial cell transforming 2 like Neighboring gene uncharacterized LOC102549233 Neighboring gene coiled-coil domain containing 28A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Intersectin 1 forms complexes with SGIP1 and Reps1 in clathrin-coated pits. Dergai O, et al. Biochem Biophys Res Commun, 2010 Nov 12. PMID 20946875
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ralBP1-associated Eps domain-containing protein 1
Names
RalBP1 associated Eps domain containing protein
ralBP1-associated Eps domain-containing protein 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394899.2 → NP_001381828.1  ralBP1-associated Eps domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A0G2JZY3
    Conserved Domains (3) summary
    smart00027
    Location:278 → 369
    EH; Eps15 homology domain
    PRK07764
    Location:131 → 228
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cl27812
    Location:6 → 85
    EF-hand_4; Cytoskeletal-regulatory complex EF hand

  2. NM_001394900.2 → NP_001381829.1  ralBP1-associated Eps domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A0G2JZY3
    Related
    ENSRNOP00000071230.2, ENSRNOT00000090703.3
    Conserved Domains (3) summary
    smart00027
    Location:278 → 369
    EH; Eps15 homology domain
    PRK07764
    Location:131 → 228
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cl27812
    Location:6 → 85
    EF-hand_4; Cytoskeletal-regulatory complex EF hand

  3. NM_001415798.1 → NP_001402727.1  ralBP1-associated Eps domain-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    Related
    ENSRNOP00000103583.1, ENSRNOT00000146715.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    14517589..14595404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105158.2 → XP_038961086.1  ralBP1-associated Eps domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GJC5
    Conserved Domains (3) summary
    smart00027
    Location:310 → 401
    EH; Eps15 homology domain
    PRK07764
    Location:163 → 260
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cl27812
    Location:6 → 85
    EF-hand_4; Cytoskeletal-regulatory complex EF hand

  2. XM_039105167.2 → XP_038961095.1  ralBP1-associated Eps domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GJC5
    Conserved Domains (3) summary
    smart00027
    Location:310 → 401
    EH; Eps15 homology domain
    PRK07764
    Location:163 → 260
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cl27812
    Location:6 → 85
    EF-hand_4; Cytoskeletal-regulatory complex EF hand

  3. XM_039105163.2 → XP_038961091.1  ralBP1-associated Eps domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6GJC5
    Conserved Domains (3) summary
    smart00027
    Location:310 → 401
    EH; Eps15 homology domain
    PRK07764
    Location:163 → 260
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cl27812
    Location:6 → 85
    EF-hand_4; Cytoskeletal-regulatory complex EF hand

  4. XM_039105171.2 → XP_038961099.1  ralBP1-associated Eps domain-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6GJC5
    Conserved Domains (3) summary
    smart00027
    Location:310 → 401
    EH; Eps15 homology domain
    PRK07764
    Location:163 → 260
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cl27812
    Location:6 → 85
    EF-hand_4; Cytoskeletal-regulatory complex EF hand

  5. XM_039105181.2 → XP_038961109.1  ralBP1-associated Eps domain-containing protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I6GJC5
    Conserved Domains (3) summary
    smart00027
    Location:310 → 401
    EH; Eps15 homology domain
    PRK07764
    Location:163 → 260
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cl27812
    Location:6 → 85
    EF-hand_4; Cytoskeletal-regulatory complex EF hand

  6. XM_039105185.2 → XP_038961113.1  ralBP1-associated Eps domain-containing protein 1 isoform X7

    UniProtKB/TrEMBL
    A0A8I6GJC5
    Conserved Domains (3) summary
    smart00027
    Location:310 → 401
    EH; Eps15 homology domain
    PRK07764
    Location:163 → 260
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cl27812
    Location:6 → 85
    EF-hand_4; Cytoskeletal-regulatory complex EF hand

  7. XM_039105175.2 → XP_038961103.1  ralBP1-associated Eps domain-containing protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I6GJC5
    Conserved Domains (3) summary
    smart00027
    Location:289 → 380
    EH; Eps15 homology domain
    PRK07764
    Location:163 → 260
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cl27812
    Location:6 → 85
    EF-hand_4; Cytoskeletal-regulatory complex EF hand

  8. XM_063284299.1 → XP_063140369.1  ralBP1-associated Eps domain-containing protein 1 isoform X8

  9. XM_039105212.2 → XP_038961140.1  ralBP1-associated Eps domain-containing protein 1 isoform X14

    UniProtKB/TrEMBL
    A0A0G2JZY3
    Related
    ENSRNOP00000091930.2, ENSRNOT00000096610.2
    Conserved Domains (3) summary
    smart00027
    Location:278 → 369
    EH; Eps15 homology domain
    PRK07764
    Location:131 → 228
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cl27812
    Location:6 → 85
    EF-hand_4; Cytoskeletal-regulatory complex EF hand

  10. XM_063284301.1 → XP_063140371.1  ralBP1-associated Eps domain-containing protein 1 isoform X11

  11. XM_063284305.1 → XP_063140375.1  ralBP1-associated Eps domain-containing protein 1 isoform X13

  12. XM_063284303.1 → XP_063140373.1  ralBP1-associated Eps domain-containing protein 1 isoform X12

  13. XM_039105204.2 → XP_038961132.1  ralBP1-associated Eps domain-containing protein 1 isoform X10

    UniProtKB/TrEMBL
    A0A8I6GJC5
    Related
    ENSRNOP00000075677.3, ENSRNOT00000089607.3
    Conserved Domains (2) summary
    smart00027
    Location:258 → 349
    EH; Eps15 homology domain
    PRK07764
    Location:111 → 208
    PRK07764; DNA polymerase III subunits gamma and tau; Validated

  14. XM_039105200.2 → XP_038961128.1  ralBP1-associated Eps domain-containing protein 1 isoform X9

    UniProtKB/TrEMBL
    A0A8I6GJC5
    Conserved Domains (2) summary
    smart00027
    Location:264 → 355
    EH; Eps15 homology domain
    PRK07764
    Location:117 → 214
    PRK07764; DNA polymerase III subunits gamma and tau; Validated

  15. XM_063284307.1 → XP_063140377.1  ralBP1-associated Eps domain-containing protein 1 isoform X15

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106264.1: Suppressed sequence

    Description
    NM_001106264.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version

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