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Map7 microtubule-associated protein 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293016, updated on 10-Oct-2024

Summary

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Official Symbol
Map7provided by RGD
Official Full Name
microtubule-associated protein 7provided by RGD
Primary source
RGD:1308866
See related
EnsemblRapid:ENSRNOG00000012701 AllianceGenome:RGD:1308866
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mtap7
Summary
Predicted to enable signaling receptor binding activity. Predicted to be involved in microtubule cytoskeleton organization and protein localization to plasma membrane. Predicted to act upstream of or within several processes, including gamete generation; male gonad development; and response to retinoic acid. Located in axon. Orthologous to human MAP7 (microtubule associated protein 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 198.7), Brain (RPKM 95.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Map7 in Genome Data Viewer
Location:
1p12
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (16730000..16857173)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (14910433..15037574)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (15620665..15748203)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 5 Neighboring gene small nucleolar RNA SNORA42/SNORA80 family Neighboring gene uncharacterized LOC102547350 Neighboring gene uncharacterized LOC120098800 Neighboring gene uncharacterized LOC120098801 Neighboring gene U6 spliceosomal RNA Neighboring gene BCL2-associated transcription factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MAP7 regulates axon morphogenesis by recruiting kinesin-1 to microtubules and modulating organelle transport. Tymanskyj SR, et al. Elife, 2018 Aug 22. PMID 30132755, Free PMC Article
  2. MAP7 Regulates Axon Collateral Branch Development in Dorsal Root Ganglion Neurons. Tymanskyj SR, et al. J Neurosci, 2017 Feb 8. PMID 28069923, Free PMC Article
  3. E-MAP-115, encoding a microtubule-associated protein, is a retinoic acid-inducible gene required for spermatogenesis. Komada M, et al. Genes Dev, 2000 Jun 1. PMID 10837026, Free PMC Article
  4. Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4). Suzuki M, et al. J Biol Chem, 2003 Dec 19. PMID 14517216
  5. Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3. Rabionet M, et al. J Biol Chem, 2008 May 9. PMID 18308723, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MAP7 recruits kinesin-1 dynamically to microtubules, leading to alterations in organelle transport behaviors, particularly pause/speed switching.
    Title: MAP7 regulates axon morphogenesis by recruiting kinesin-1 to microtubules and modulating organelle transport.
  2. MAP7 promotes axon collateral branch morphogenesis and neural circuit function in dorsal root ganglion neurons.
    Title: MAP7 Regulates Axon Collateral Branch Development in Dorsal Root Ganglion Neurons.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Leydig cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within Sertoli cell development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fertilization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within germ cell development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glycosphingolipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within homeostasis of number of cells ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within microtubule bundle formation ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within nucleus organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within organ growth ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to osmotic stress ISO
Inferred from Sequence Orthology
more info
  
involved_in response to osmotic stress ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to retinoic acid ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ensconsin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106270.2 → NP_001099740.2  ensconsin isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6GKH8
    Related
    ENSRNOP00000099528.1, ENSRNOT00000126107.1
    Conserved Domains (1) summary
    pfam05672
    Location:471 → 623
    MAP7; MAP7 (E-MAP-115) family

  2. NM_001198638.2 → NP_001185567.1  ensconsin isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon and lacks in-frame two consecutive exons in the CDS, as comapared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus and lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6AJJ5
    Related
    ENSRNOP00000098641.1, ENSRNOT00000139018.1
    Conserved Domains (1) summary
    pfam05672
    Location:368 → 520
    MAP7; MAP7 (E-MAP-115) family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    16730000..16857173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105408.2 → XP_038961336.1  ensconsin isoform X4

    UniProtKB/TrEMBL
    A0A8I6AJJ5, F1MA82
    Related
    ENSRNOP00000017401.6, ENSRNOT00000017401.7
    Conserved Domains (2) summary
    pfam05672
    Location:451 → 603
    MAP7; MAP7 (E-MAP-115) family
    pfam06098
    Location:89 → 146
    Radial_spoke_3; Radial spoke protein 3

  2. XM_063284418.1 → XP_063140488.1  ensconsin isoform X10

    Related
    ENSRNOP00000093262.2, ENSRNOT00000094977.2

  3. XM_039105409.2 → XP_038961337.1  ensconsin isoform X5

    UniProtKB/TrEMBL
    A0A8I6AJJ5
    Related
    ENSRNOP00000079962.2, ENSRNOT00000096725.2
    Conserved Domains (2) summary
    pfam05672
    Location:443 → 595
    MAP7; MAP7 (E-MAP-115) family
    pfam06098
    Location:89 → 146
    Radial_spoke_3; Radial spoke protein 3

  4. XM_063284425.1 → XP_063140495.1  ensconsin isoform X12

  5. XM_039105391.2 → XP_038961319.1  ensconsin isoform X1

    UniProtKB/TrEMBL
    A0A8I6GKH8
    Conserved Domains (2) summary
    pfam05672
    Location:473 → 625
    MAP7; MAP7 (E-MAP-115) family
    pfam06098
    Location:111 → 168
    Radial_spoke_3; Radial spoke protein 3

  6. XM_063284427.1 → XP_063140497.1  ensconsin isoform X12

  7. XM_063284432.1 → XP_063140502.1  ensconsin isoform X13

  8. XM_039105431.2 → XP_038961359.1  ensconsin isoform X6

    UniProtKB/TrEMBL
    A0A8I6AJJ5
    Conserved Domains (2) summary
    pfam05672
    Location:431 → 583
    MAP7; MAP7 (E-MAP-115) family
    pfam06098
    Location:69 → 126
    Radial_spoke_3; Radial spoke protein 3

  9. XM_063284408.1 → XP_063140478.1  ensconsin isoform X7

    UniProtKB/TrEMBL
    A0A8I6AJA9
    Related
    ENSRNOP00000075655.3, ENSRNOT00000079845.3

  10. XM_039105407.2 → XP_038961335.1  ensconsin isoform X2

    UniProtKB/TrEMBL
    A0A8I6AJJ5
    Conserved Domains (2) summary
    pfam05672
    Location:460 → 612
    MAP7; MAP7 (E-MAP-115) family
    pfam06098
    Location:98 → 155
    Radial_spoke_3; Radial spoke protein 3

  11. XM_063284402.1 → XP_063140472.1  ensconsin isoform X3

    UniProtKB/TrEMBL
    A0A0G2KB52
    Related
    ENSRNOP00000093069.2, ENSRNOT00000098943.2

  12. XM_063284410.1 → XP_063140480.1  ensconsin isoform X8

  13. XM_063284414.1 → XP_063140484.1  ensconsin isoform X9

    UniProtKB/TrEMBL
    A0A8I5ZPN4

  14. XM_063284422.1 → XP_063140492.1  ensconsin isoform X11

Nucleotide Protein Strain
Heading Accession and Version

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