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Whamm WASP homolog associated with actin, golgi membranes and microtubules [ Rattus norvegicus (Norway rat) ]

Gene ID: 293057, updated on 2-Nov-2024

Summary

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Official Symbol
Whammprovided by RGD
Official Full Name
WASP homolog associated with actin, golgi membranes and microtubulesprovided by RGD
Primary source
RGD:1563506
See related
EnsemblRapid:ENSRNOG00000028113 AllianceGenome:RGD:1563506
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Whdc1; RGD1563506
Summary
Predicted to enable Arp2/3 complex binding activity; microtubule binding activity; and small GTPase binding activity. Predicted to be involved in several processes, including Arp2/3 complex-mediated actin nucleation; focal adhesion assembly; and plasma membrane tubulation. Predicted to be located in Golgi membrane and cytosol. Predicted to be active in endoplasmic reticulum-Golgi intermediate compartment membrane. Orthologous to several human genes including WHAMM (WASP homolog associated with actin, golgi membranes and microtubules). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 55.4), Kidney (RPKM 40.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Whamm in Genome Data Viewer
Location:
1q31
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (144935588..144963989)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (135526363..135557091)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (143401986..143430356)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small Cajal body-specific RNA 15 Neighboring gene small nucleolar RNA SNORA76 Neighboring gene fibronectin type III and SPRY domain containing 2 Neighboring gene homer scaffold protein 2 Neighboring gene RNA, U6 small nuclear 946 Neighboring gene RNA guanine-7 methyltransferase activating subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. WHAMM initiates autolysosome tubulation by promoting actin polymerization on autolysosomes. Dai A, et al. Nat Commun, 2019 Aug 16. PMID 31420534, Free PMC Article
  2. WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport. Campellone KG, et al. Cell, 2008 Jul 11. PMID 18614018, Free PMC Article
  3. RhoD regulates cytoskeletal dynamics via the actin nucleation-promoting factor WASp homologue associated with actin Golgi membranes and microtubules. Gad AK, et al. Mol Biol Cell, 2012 Dec. PMID 23087206, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables Arp2/3 complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Arp2/3 complex binding ISO
Inferred from Sequence Orthology
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in plasma membrane tubulation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of actin nucleation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum-Golgi intermediate compartment membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
WASP homolog-associated protein with actin, membranes and microtubules
Names
WAS protein homolog associated with actin, golgi membranes and microtubules
WAS protein homology region 2 domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130728.1 → NP_001124200.1  WASP homolog-associated protein with actin, membranes and microtubules

    See identical proteins and their annotated locations for NP_001124200.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473980
    UniProtKB/TrEMBL
    A6JCG9, D3ZKN4
    Related
    ENSRNOP00000060843.2, ENSRNOT00000064667.3
    Conserved Domains (2) summary
    pfam15871
    Location:67 → 435
    JMY; Junction-mediating and -regulatory protein
    pfam15920
    Location:5 → 47
    WHAMM-JMY_N; N-terminal of Junction-mediating and WASP homolog-associated

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    144935588..144963989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105687.2 → XP_038961615.1  WASP homolog-associated protein with actin, membranes and microtubules isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y913
    Conserved Domains (1) summary
    pfam15871
    Location:1 → 130
    JMY; Junction-mediating and -regulatory protein

RNA

  1. XR_005501963.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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