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Tmem135 transmembrane protein 135 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293098, updated on 17-Aug-2024

Summary

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Official Symbol
Tmem135provided by RGD
Official Full Name
transmembrane protein 135provided by RGD
Primary source
RGD:1309948
See related
EnsemblRapid:ENSRNOG00000016815 AllianceGenome:RGD:1309948
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PMP52; RGD1309948
Summary
Involved in peroxisome organization. Located in peroxisome. Orthologous to human TMEM135 (transmembrane protein 135). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 245.9), Adrenal (RPKM 147.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tmem135 in Genome Data Viewer
Location:
1q32
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (152418929..152692405, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (143006343..143279824, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (152886496..153096225, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene phosphoglycerate kinase 1, pseudogene 7 Neighboring gene ribosomal protein S19, pseudogene 10 Neighboring gene frizzled class receptor 4 Neighboring gene protein tyrosine phosphatase 4A1, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies. Lee WH, et al. Elife, 2016 Nov 15. PMID 27863209, Free PMC Article
  2. Proteomics characterization of mouse kidney peroxisomes by tandem mass spectrometry and protein correlation profiling. Wiese S, et al. Mol Cell Proteomics, 2007 Dec. PMID 17768142
  3. Rat liver peroxisomes after fibrate treatment. A survey using quantitative mass spectrometry. Islinger M, et al. J Biol Chem, 2007 Aug 10. PMID 17522052
  4. Stressed-induced TMEM135 protein is part of a conserved genetic network involved in fat storage and longevity regulation in Caenorhabditis elegans. Exil VJ, et al. PLoS One, 2010 Dec 3. PMID 21151927, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
involved_in peroxisome organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of mitochondrial fission ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrial fission ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of oxidative phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to cold ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to food ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within retinal pigment epithelium development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane protein 135
Names
peroxisomal membrane protein 52

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013896.1 → NP_001013918.1  transmembrane protein 135

    See identical proteins and their annotated locations for NP_001013918.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085115
    UniProtKB/Swiss-Prot
    Q5U4F4
    UniProtKB/TrEMBL
    A0A8I6G425, A6I5Z6
    Related
    ENSRNOP00000022578.4, ENSRNOT00000022578.7
    Conserved Domains (2) summary
    pfam02466
    Location:249 → 338
    Tim17; Tim17/Tim22/Tim23/Pmp24 family
    pfam15982
    Location:9 → 142
    TMEM135_C_rich; N-terminal cysteine-rich region of Transmembrane protein 135

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    152418929..152692405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105814.2 → XP_038961742.1  transmembrane protein 135 isoform X3

    Conserved Domains (1) summary
    pfam02466
    Location:171 → 223
    Tim17; Tim17/Tim22/Tim23/Pmp24 family

  2. XM_039105818.2 → XP_038961746.1  transmembrane protein 135 isoform X4

    Conserved Domains (1) summary
    pfam02466
    Location:160 → 212
    Tim17; Tim17/Tim22/Tim23/Pmp24 family

  3. XM_039105799.2 → XP_038961727.1  transmembrane protein 135 isoform X1

    Conserved Domains (2) summary
    pfam15982
    Location:2 → 23
    TMEM135_C_rich; N-terminal cysteine-rich region of Transmembrane protein 135
    pfam02466
    Location:180 → 232
    Tim17; Tim17/Tim22/Tim23/Pmp24 family

  4. XM_039105807.2 → XP_038961735.1  transmembrane protein 135 isoform X2

    Conserved Domains (2) summary
    pfam15982
    Location:2 → 22
    TMEM135_C_rich; N-terminal cysteine-rich region of Transmembrane protein 135
    pfam02466
    Location:179 → 231
    Tim17; Tim17/Tim22/Tim23/Pmp24 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U4F4.1 GenPept UniProtKB/Swiss-Prot:Q5U4F4

Gene LinkOut

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