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Mrpl48 mitochondrial ribosomal protein L48 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293149, updated on 2-Nov-2024

Summary

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Symbol
Mrpl48provided by RGD
Full Name
mitochondrial ribosomal protein L48provided by RGD
Primary source
RGD:1307576
See related
EnsemblRapid:ENSRNOG00000018042 AllianceGenome:RGD:1307576
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be located in mitochondrion. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in mitochondrial ribosome. Orthologous to human MRPL48 (mitochondrial ribosomal protein L48). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 292.2), Muscle (RPKM 246.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mrpl48 in Genome Data Viewer
Location:
1q32
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (164308787..164370034, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (154896663..154939285, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (165563788..165606375, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103691200 Neighboring gene uncharacterized LOC120099893 Neighboring gene uncharacterized LOC120099894 Neighboring gene cytochrome c oxidase assembly factor 4 homolog Neighboring gene small nucleolar RNA SNORA4 Neighboring gene RAB6A, member RAS oncogene family Neighboring gene pleckstrin homology domain containing B1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Properties of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L and its interactions with mammalian mitochondrial ribosomes. Haque ME, et al. J Biol Chem, 2010 Sep 3. PMID 20601428, Free PMC Article
  2. Structures of the human mitochondrial ribosome in native states of assembly. Brown A, et al. Nat Struct Mol Biol, 2017 Oct. PMID 28892042, Free PMC Article
  3. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrial ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial ribosome ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein mL48
Names
39S ribosomal protein L48, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106282.1 → NP_001099752.1  large ribosomal subunit protein mL48 isoform 2

    See identical proteins and their annotated locations for NP_001099752.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473956
    UniProtKB/TrEMBL
    A0A8I6APR3, A6I6P8, D3ZDX7
    Related
    ENSRNOP00000096505.2, ENSRNOT00000097667.2
    Conserved Domains (2) summary
    smart00487
    Location:132 → 194
    DEXDc; DEAD-like helicases superfamily
    pfam00338
    Location:91 → 185
    Ribosomal_S10; Ribosomal protein S10p/S20e

  2. NM_001428992.1 → NP_001415921.1  large ribosomal subunit protein mL48 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

  3. NM_001428993.1 → NP_001415922.1  large ribosomal subunit protein mL48 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    164308787..164370034 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285143.1 → XP_063141213.1  large ribosomal subunit protein mL48 isoform X1

    Related
    ENSRNOP00000104124.1, ENSRNOT00000140762.1

  2. XM_039106102.2 → XP_038962030.1  large ribosomal subunit protein mL48 isoform X4

    UniProtKB/TrEMBL
    A0A8I5Y9S3, A6I6P9
    Conserved Domains (1) summary
    pfam00338
    Location:1 → 87
    Ribosomal_S10; Ribosomal protein S10p/S20e

  3. XM_039106100.2 → XP_038962028.1  large ribosomal subunit protein mL48 isoform X4

    UniProtKB/TrEMBL
    A0A8I5Y9S3, A6I6P9
    Conserved Domains (1) summary
    pfam00338
    Location:1 → 87
    Ribosomal_S10; Ribosomal protein S10p/S20e

  4. XM_063285156.1 → XP_063141226.1  large ribosomal subunit protein mL48 isoform X3

  5. XM_063285146.1 → XP_063141216.1  large ribosomal subunit protein mL48 isoform X2

RNA

  1. XR_010065073.1 RNA Sequence

  2. XR_010065072.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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