U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hbe1 hemoglobin subunit epsilon 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293267, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Hbe1provided by RGD
Official Full Name
hemoglobin subunit epsilon 1provided by RGD
Primary source
RGD:1305115
See related
EnsemblRapid:ENSRNOG00000029286 AllianceGenome:RGD:1305115
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Glnb1; Hbb-y
Summary
Enables hemoglobin alpha binding activity. Involved in response to organic cyclic compound. Part of hemoglobin complex. Human ortholog(s) of this gene implicated in sickle cell anemia. Orthologous to human HBE1 (hemoglobin subunit epsilon 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 52.8) and Testes (RPKM 13.2) See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Hbe1 in Genome Data Viewer
Location:
1q32
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (167694820..167872091, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (158282931..158458855, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (169003904..169005184, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene hemoglobin subunit gamma 1 Neighboring gene hemoglobin, epsilon 2 Neighboring gene olfactory receptor family 51 subfamily B member 4B Neighboring gene olfactory receptor family 51 subfamily B member 4 Neighboring gene olfactory receptor family 51 subfamily B member 17 Neighboring gene olfactory receptor family 51 subfamily B member 6 Neighboring gene olfactory receptor family 51 subfamily M member 1, pseudogene 1 Neighboring gene olfactory receptor pseudogene 134 Neighboring gene olfactory receptor family 51 subfamily K member 2 Neighboring gene olfactory receptor family 51 subfamily K member 7 Neighboring gene transmembrane p24 trafficking protein 5, pseudogene 1 Neighboring gene olfactory receptor family 51 subfamily K member 1B, pseudogene 1 Neighboring gene olfactory receptor family 51 subfamily Q member 1D Neighboring gene uncharacterized LOC134484818 Neighboring gene MLV-related proviral Env polyprotein-like Neighboring gene sorting nexin 12, pseudogene 1 Neighboring gene olfactory receptor family 51 subfamily Q member 1 Neighboring gene olfactory receptor family 51 subfamily Q member 1E Neighboring gene olfactory receptor family 51 subfamily K member 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Candidate sequence variants and fetal hemoglobin in children with sickle cell disease treated with hydroxyurea. Green NS, et al. PLoS One, 2013. PMID 23409025, Free PMC Article
  2. Gene expression profiling of androgen receptor antagonists in the rat fetal testis reveals few common gene targets. Mu X, et al. J Biochem Mol Toxicol, 2006. PMID 16498641
  3. A human embryonic hemoglobin inhibits Hb S polymerization in vitro and restores a normal phenotype to mouse models of sickle cell disease. He Z, et al. Proc Natl Acad Sci U S A, 2002 Aug 6. PMID 12124399, Free PMC Article
  4. Identification of five embryonic hemoglobins of rat and ontogeny of their constituent globins during fetal development. Iwahara SI, et al. J Biochem, 1996 Feb. PMID 8882731
  5. Molecular cloning and characterization of two sets of alpha-theta genes in the rat alpha-like globin gene cluster. Satoh H, et al. Gene, 1999 Apr 1. PMID 10196478

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to haptoglobin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hemoglobin alpha binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hemoglobin alpha binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables organic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxygen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxygen carrier activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in oxygen transport ISO
Inferred from Sequence Orthology
more info
  
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
part_of haptoglobin-hemoglobin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of hemoglobin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of hemoglobin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of hemoglobin complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
hemoglobin subunit epsilon 1
Names
epsilon 1 globin
globin b1
hemoglobin Y, beta-like embryonic chain
hemoglobin, epsilon 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008890.2 → NP_001008890.1  hemoglobin subunit epsilon 1

    See identical proteins and their annotated locations for NP_001008890.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A1K0GY47, O88752
    Related
    ENSRNOP00000040010.2, ENSRNOT00000043719.6
    Conserved Domains (1) summary
    cd08925
    Location:7 → 146
    Hb-beta_like; Hemoglobin beta, gamma, delta, epsilon, and related Hb subunits

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    167694820..167872091 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039106648.2 → XP_038962576.1  hemoglobin subunit epsilon 1 isoform X1

    Conserved Domains (1) summary
    cd08925
    Location:8 → 123
    Hb-beta-like; Hemoglobin beta, gamma, delta, epsilon, and related Hb subunits

  2. XM_039106650.2 → XP_038962578.1  hemoglobin subunit epsilon 1 isoform X1

    Conserved Domains (1) summary
    cd08925
    Location:8 → 123
    Hb-beta-like; Hemoglobin beta, gamma, delta, epsilon, and related Hb subunits

  3. XM_063285351.1 → XP_063141421.1  hemoglobin subunit epsilon 1 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools