Prdx2 peroxiredoxin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prdx2provided by RGD
Official Full Name: peroxiredoxin 2provided by RGD
Primary source: RGD:3838
See related: EnsemblRapid:ENSRNOG00000003520 AllianceGenome:RGD:3838
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tdpx1
Summary: Predicted to enable thioredoxin peroxidase activity. Involved in negative regulation of neuron apoptotic process and response to oxidative stress. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human PRDX2 (peroxiredoxin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 2379.0), Spleen (RPKM 2155.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (40085788..40091083, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (23180927..23186217, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (26084816..26090095)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intracerebral Hemorrhage-Induced Brain Injury in Rats: the Role of Extracellular Peroxiredoxin 2.
Title: Intracerebral Hemorrhage-Induced Brain Injury in Rats: the Role of Extracellular Peroxiredoxin 2.
Peroxiredoxin2 (Prdx2) Reduces Oxidative Stress and Apoptosis of Myocardial Cells Induced by Acute Myocardial Infarction by Inhibiting the TLR4/Nuclear Factor kappa B (NF-kappaB) Signaling Pathway.
Title: Peroxiredoxin2 (Prdx2) Reduces Oxidative Stress and Apoptosis of Myocardial Cells Induced by Acute Myocardial Infarction by Inhibiting the TLR4/Nuclear Factor kappa B (NF-κB) Signaling Pathway.
Prx2 (Peroxiredoxin 2) as a Cause of Hydrocephalus After Intraventricular Hemorrhage.
Title: Prx2 (Peroxiredoxin 2) as a Cause of Hydrocephalus After Intraventricular Hemorrhage.
Effects of the Prdx2 depletion on blood pressure and life span in spontaneously hypertensive rats.
Title: Effects of the Prdx2 depletion on blood pressure and life span in spontaneously hypertensive rats.
a critical role for Trx1 and Prdx2 in the cardiac hypertrophy of H9c2 cells and in the transition from compensated hypertrophy to de-compensated hypertrophy in H9c2 cells.
Title: Alterations in NO/ROS ratio and expression of Trx1 and Prdx2 in isoproterenol-induced cardiac hypertrophy.
Prdx2 may prevent H2O2 accumulation in Leydig cells, and may be important in oxidative stressinduced apoptosis and decreased testosterone production.
Title: Role of peroxiredoxin 2 in H2O2‑induced oxidative stress of primary Leydig cells.
Prdx 2 expression in perinatal rat brain remained largely unchanged.
Title: Expression of peroxiredoxin 1, 2, and 6 in the rat brain during perinatal development and in response to dexamethasone.
Peroxiredoxin 2 is an important modulator of angiotensin II-induced podocyte injury.
Title: Downregulation of the antioxidant protein peroxiredoxin 2 contributes to angiotensin II-mediated podocyte apoptosis.
ATP and exogenous H2O2 stimulated Prx II shifting from oxidized form to reduced form. RBA-2 astrocytes expressed Prx II that might also serve as a protective mechanism to control the concentration of reactive oxygen species.
Title: Elucidation of ATP-stimulated stress protein expression of RBA-2 type-2 astrocytes: ATP potentiate HSP60 and Cu/Zn SOD expression and stimulates pI shift of peroxiredoxin II.
Prx2 is implied in the regulation of hydrogen peroxide production in the bone marrow during aging.
Title: Proteomic analysis of interstitial fluid in bone marrow identified that peroxiredoxin 2 regulates H(2)O(2) level of bone marrow during aging.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tdpx-ps2 (e-PCR), detects polymorphism
- UniSTS:259335

UniSTS:234183 (e-PCR)
- UniSTS:234183

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables antioxidant activity	ISO Inferred from Sequence Orthology more info
enables peroxidase activity	IEA Inferred from Electronic Annotation more info
enables thioredoxin peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thioredoxin peroxidase activity	IEA Inferred from Electronic Annotation more info
enables thioredoxin peroxidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within T cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in T cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell redox homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in defense response to tumor cell	IEA Inferred from Electronic Annotation more info
involved_in defense response to tumor cell	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in hydrogen peroxide catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hydrogen peroxide catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hydrogen peroxide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in leukocyte activation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipopolysaccharide-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of hydrogen peroxide metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of hydrogen peroxide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in removal of superoxide radicals	IBA Inferred from Biological aspect of Ancestor more info
involved_in removal of superoxide radicals	IEA Inferred from Electronic Annotation more info
involved_in removal of superoxide radicals	ISO Inferred from Sequence Orthology more info
involved_in respiratory burst involved in inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within respiratory burst involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in thymus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within thymus development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: peroxiredoxin-2

Names: TSA; thiol-specific antioxidant protein; thioredoxin peroxidase 1; thioredoxin-dependent peroxide reductase 1; thioredoxin-dependent peroxiredoxin 2

NP_058865.2

EC 1.11.1.24

XP_006255306.1

EC 1.11.1.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017169.2 → NP_058865.2 peroxiredoxin-2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

P35704, Q6PDV3

UniProtKB/TrEMBL

A0A0G2JSH9, A6IY46

Conserved Domains (1) summary

cd03015
Location:8 → 179

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

40085788..40091083 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006255244.3 → XP_006255306.1 peroxiredoxin-2 isoform X1

See identical proteins and their annotated locations for XP_006255306.1

UniProtKB/Swiss-Prot

P35704, Q6PDV3

UniProtKB/TrEMBL

A0A0G2JSH9, A6IY46

Related

ENSRNOP00000004799.2, ENSRNOT00000004799.7

Conserved Domains (1) summary

cd03015
Location:8 → 179

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...