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Prkacb protein kinase cAMP-activated catalytic subunit beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 293508, updated on 2-Nov-2024

Summary

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Official Symbol
Prkacbprovided by RGD
Official Full Name
protein kinase cAMP-activated catalytic subunit betaprovided by RGD
Primary source
RGD:1310574
See related
EnsemblRapid:ENSRNOG00000004978 AllianceGenome:RGD:1310574
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables cAMP-dependent protein kinase activity. Involved in negative regulation of meiotic cell cycle and protein phosphorylation. Located in perinuclear region of cytoplasm. Part of cAMP-dependent protein kinase complex. Biomarker of brain ischemia. Orthologous to human PRKACB (protein kinase cAMP-activated catalytic subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 561.4), Adrenal (RPKM 229.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Prkacb in Genome Data Viewer
Location:
2q44
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (238297140..238389317, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (235636878..235726928, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (252602197..252691886, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100966 Neighboring gene uncharacterized LOC134485994 Neighboring gene tubulin tyrosine ligase like 7 Neighboring gene uncharacterized LOC108350293

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular structure of the C beta catalytic subunit of rat cAMP-dependent protein kinase and differential expression of C alpha and C beta isoforms in rat tissues and cultured cells. Shuntoh H, et al. Biochim Biophys Acta, 1992 Jun 15. PMID 1610898
  2. Isolation of a complementary DNA encoding the catalytic subunit of protein kinase A and studies on the expression of this sequence in rat hepatomas and regenerating liver. Roth JS, et al. Cancer Res, 1990 Mar 15. PMID 2306720
  3. Regulation of mRNA expression involved in Ras and PKA signal pathways during rat hypoglossal nerve regeneration. Kiryu S, et al. Brain Res Mol Brain Res, 1995 Mar. PMID 7769990
  4. Impairment of cerebral cAMP-mediated signal transduction system and of spatial memory function after microsphere embolism in rats. Nagakura A, et al. Neuroscience, 2002. PMID 12150772
  5. Stimulation of c-Rel transcriptional activity by PKA catalytic subunit beta. Yu SH, et al. J Mol Med (Berl), 2004 Sep. PMID 15197457

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cAMP-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cAMP-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cAMP-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cAMP-dependent protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein kinase A regulatory subunit binding IC
Inferred by Curator
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
  
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of TORC1 signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of TORC1 signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of meiotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in neural tube closure IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neural tube closure ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of protein processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of cAMP-dependent protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cAMP-dependent protein kinase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary base IEA
Inferred from Electronic Annotation
more info
  
located_in ciliary base ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cAMP-dependent protein kinase catalytic subunit beta
Names
PKA C-beta
protein kinase, cAMP dependent, catalytic, beta
protein kinase, cAMP-dependent, beta catalytic subunit
NP_001071113.1
XP_006233513.1
XP_006233514.1
XP_006233515.1
XP_038957812.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077645.1 → NP_001071113.1  cAMP-dependent protein kinase catalytic subunit beta

    See identical proteins and their annotated locations for NP_001071113.1

    Status: PROVISIONAL

    Source sequence(s)
    D10770
    UniProtKB/Swiss-Prot
    P68182
    UniProtKB/TrEMBL
    A0A8I6GBC1, A6HWE9
    Related
    ENSRNOP00000062228.1, ENSRNOT00000068739.3
    Conserved Domains (1) summary
    cd14209
    Location:42 → 331
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    238297140..238389317 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233451.5 → XP_006233513.1  cAMP-dependent protein kinase catalytic subunit beta isoform X1

    See identical proteins and their annotated locations for XP_006233513.1

    UniProtKB/TrEMBL
    A0A8I6A4F6, A0A8I6GBC1, A6HWF0
    Related
    ENSRNOP00000086804.1, ENSRNOT00000119887.2
    Conserved Domains (2) summary
    PTZ00263
    Location:79 → 398
    PTZ00263; protein kinase A catalytic subunit; Provisional
    cd14209
    Location:89 → 378
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  2. XM_006233452.5 → XP_006233514.1  cAMP-dependent protein kinase catalytic subunit beta isoform X2

    See identical proteins and their annotated locations for XP_006233514.1

    UniProtKB/TrEMBL
    A0A8I6GBC1, A6HWF1
    Related
    ENSRNOP00000109470.1, ENSRNOT00000127717.1
    Conserved Domains (1) summary
    cd14209
    Location:30 → 319
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  3. XM_006233453.5 → XP_006233515.1  cAMP-dependent protein kinase catalytic subunit beta isoform X3

    See identical proteins and their annotated locations for XP_006233515.1

    UniProtKB/TrEMBL
    A0A8I6AV42, A6HWF2, Q05759
    Related
    ENSRNOP00000092040.1, ENSRNOT00000117576.2
    Conserved Domains (1) summary
    cd14209
    Location:29 → 318
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  4. XM_039101884.2 → XP_038957812.2  cAMP-dependent protein kinase catalytic subunit beta isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P68182.2 GenPept UniProtKB/Swiss-Prot:P68182

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