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Ate1 arginyltransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293526, updated on 18-Sep-2024

Summary

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Official Symbol
Ate1provided by RGD
Official Full Name
arginyltransferase 1provided by RGD
Primary source
RGD:1309335
See related
EnsemblRapid:ENSRNOG00000024414 AllianceGenome:RGD:1309335
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable arginyltransferase activity. Predicted to be involved in protein arginylation. Predicted to act upstream of or within proteasomal protein catabolic process. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human ATE1 (arginyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 163.9), Lung (RPKM 162.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ate1 in Genome Data Viewer
Location:
1q37
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (194391843..194514284, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (184961548..185081112, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (200958564..201082100, complement) , (200810741..200885593, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100911081 Neighboring gene protein UXT-like Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene similar to RIKEN cDNA 1700022C21 Neighboring gene uncharacterized LOC134483930 Neighboring gene NSE4 homolog A, SMC5-SMC6 complex component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Arginyltransferase knockdown attenuates cardiac hypertrophy and fibrosis through TAK1-JNK1/2 pathway. Singh K, et al. Sci Rep, 2020 Jan 17. PMID 31953451, Free PMC Article
  2. Identification of mammalian arginyltransferases that modify a specific subset of protein substrates. Rai R, et al. Proc Natl Acad Sci U S A, 2005 Jul 19. PMID 16002466, Free PMC Article
  3. Alternative splicing results in differential expression, activity, and localization of the two forms of arginyl-tRNA-protein transferase, a component of the N-end rule pathway. Kwon YT, et al. Mol Cell Biol, 1999 Jan. PMID 9858543, Free PMC Article
  4. FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex. Sjögren B, et al. PLoS One, 2015. PMID 25970626, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arginyltransferase knockdown attenuates cardiac hypertrophy and fibrosis through TAK1-JNK1/2 pathway.
    Title: Arginyltransferase knockdown attenuates cardiac hypertrophy and fibrosis through TAK1-JNK1/2 pathway.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables arginyl-tRNA--protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arginyl-tRNA--protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in proteasomal protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein arginylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein arginylation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
arginyl-tRNA--protein transferase 1
Names
arginine-tRNA-protein transferase 1
NP_001099770.1
NP_001385686.1
NP_001385687.1
NP_001385688.1
NP_001385689.1
XP_038963488.1
XP_038963491.1
XP_038963503.1
XP_063142421.1
XP_063142431.1
XP_063142435.1
XP_063142439.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106300.2 → NP_001099770.1  arginyl-tRNA--protein transferase 1 isoform 3

    See identical proteins and their annotated locations for NP_001099770.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6IA33, A6IA34, D4A2N1
    Related
    ENSRNOP00000059441.1, ENSRNOT00000067315.4
    Conserved Domains (2) summary
    pfam04376
    Location:20 → 92
    ATE_N; Arginine-tRNA-protein transferase, N terminus
    pfam04377
    Location:292 → 422
    ATE_C; Arginine-tRNA-protein transferase, C terminus

  2. NM_001398757.1 → NP_001385686.1  arginyl-tRNA--protein transferase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6AL43, A0A8I6G6E2
    Related
    ENSRNOP00000100383.1, ENSRNOT00000173542.1
    Conserved Domains (2) summary
    pfam04376
    Location:23 → 92
    ATE_N; Arginine-tRNA-protein transferase, N-terminus
    pfam04377
    Location:292 → 431
    ATE_C; Arginine-tRNA-protein transferase, C-terminus

  3. NM_001398758.1 → NP_001385687.1  arginyl-tRNA--protein transferase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6G6E2
    Conserved Domains (2) summary
    pfam04376
    Location:23 → 92
    ATE_N; Arginine-tRNA-protein transferase, N-terminus
    pfam04377
    Location:292 → 431
    ATE_C; Arginine-tRNA-protein transferase, C-terminus

  4. NM_001398759.1 → NP_001385688.1  arginyl-tRNA--protein transferase 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6GEE1, A6IA33
    Related
    ENSRNOP00000086773.1, ENSRNOT00000101371.2
    Conserved Domains (2) summary
    pfam04376
    Location:23 → 92
    ATE_N; Arginine-tRNA-protein transferase, N-terminus
    pfam04377
    Location:265 → 388
    ATE_C; Arginine-tRNA-protein transferase, C-terminus

  5. NM_001398760.1 → NP_001385689.1  arginyl-tRNA--protein transferase 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6G6E2
    Conserved Domains (2) summary
    pfam04377
    Location:226 → 365
    ATE_C; Arginine-tRNA-protein transferase, C-terminus
    cl27166
    Location:1 → 26
    ATE_N; Arginine-tRNA-protein transferase, N-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    194391843..194514284 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286351.1 → XP_063142421.1  arginyl-tRNA--protein transferase 1 isoform X3

    UniProtKB/TrEMBL
    A6IA33

  2. XM_039107563.2 → XP_038963491.1  arginyl-tRNA--protein transferase 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6G6E2
    Related
    ENSRNOP00000080291.2, ENSRNOT00000106036.2
    Conserved Domains (2) summary
    pfam04376
    Location:16 → 85
    ATE_N; Arginine-tRNA-protein transferase, N-terminus
    pfam04377
    Location:285 → 424
    ATE_C; Arginine-tRNA-protein transferase, C-terminus

  3. XM_039107560.2 → XP_038963488.1  arginyl-tRNA--protein transferase 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JX45, A0A8I6G6E2
    Related
    ENSRNOP00000070130.1, ENSRNOT00000079342.3
    Conserved Domains (2) summary
    pfam04376
    Location:16 → 85
    ATE_N; Arginine-tRNA-protein transferase, N-terminus
    pfam04377
    Location:285 → 424
    ATE_C; Arginine-tRNA-protein transferase, C-terminus

  4. XM_063286369.1 → XP_063142439.1  arginyl-tRNA--protein transferase 1 isoform X7

    UniProtKB/TrEMBL
    A0A8I6G6E2

  5. XM_063286365.1 → XP_063142435.1  arginyl-tRNA--protein transferase 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I6G6E2
    Related
    ENSRNOP00000096095.2, ENSRNOT00000112918.2

  6. XM_039107575.2 → XP_038963503.1  arginyl-tRNA--protein transferase 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6G6E2
    Conserved Domains (2) summary
    pfam04377
    Location:226 → 365
    ATE_C; Arginine-tRNA-protein transferase, C-terminus
    cl27166
    Location:1 → 26
    ATE_N; Arginine-tRNA-protein transferase, N-terminus

  7. XM_063286361.1 → XP_063142431.1  arginyl-tRNA--protein transferase 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I6G6E2
Nucleotide Protein Strain
Heading Accession and Version

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