Pla2g5 phospholipase A2, group V [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pla2g5provided by RGD
Official Full Name: phospholipase A2, group Vprovided by RGD
Primary source: RGD:62051
See related: EnsemblRapid:ENSRNOG00000016838 AllianceGenome:RGD:62051
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PLA2-10
Summary: Enables calcium-dependent phospholipase A2 activity and heparin binding activity. Involved in several processes, including arachidonate secretion; leukotriene biosynthetic process; and platelet activating factor biosynthetic process. Located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in familial benign fleck retina. Orthologous to human PLA2G5 (phospholipase A2 group V). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 104.3), Thymus (RPKM 11.1) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 5q36

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (156324628..156393065, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (151041339..151109433, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (157247601..157268968, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prostaglandin E1 plays a role in therapy of coronary heart disease and atherosclerosis by regulating serum estrogen and FSH levels, and myocardium sPLA2-V protein expression.
Title: Expression of sPLA2-V, estrogen and its target protein in myocardium tissue.
During pleurisy resolution there is a switch to a sequential induction of first sPLA2 (types IIa and V) that mediates the release of PAF and lipoxin A4.
Title: A novel role for phospholipase A2 isoforms in the checkpoint control of acute inflammation.

Submit: New GeneRIF Correction

General gene information

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Markers

RH143028 (e-PCR)
- UniSTS:232275

RH134706 (e-PCR)
- UniSTS:217984

RH144651 (e-PCR)
- UniSTS:233896

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium-independent phospholipase A2 activity	IEA Inferred from Electronic Annotation more info
enables calcium-independent phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase A2 activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in arachidonate secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in arachidonate secretion	IEA Inferred from Electronic Annotation more info
involved_in arachidonate secretion	ISO Inferred from Sequence Orthology more info
involved_in cardiolipin acyl-chain remodeling	IEA Inferred from Electronic Annotation more info
involved_in cardiolipin acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in cardiolipin acyl-chain remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in leukotriene biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in leukotriene biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in leukotriene biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within low-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in low-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in low-density lipoprotein particle remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in phagosome-lysosome fusion	ISO Inferred from Sequence Orthology more info
involved_in phagosome-lysosome fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylcholine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylcholine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylcholine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylglycerol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in platelet activating factor biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of antifungal innate immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of antifungal innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of immune complex clearance by monocytes and macrophages	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of immune complex clearance by monocytes and macrophages	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immune complex clearance by monocytes and macrophages	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of macrophage derived foam cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage derived foam cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of opsonization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of opsonization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phagosome maturation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagosome maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phospholipase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phospholipase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cytokine	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in early phagosome	ISO Inferred from Sequence Orthology more info
located_in early phagosome	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in phagolysosome	ISO Inferred from Sequence Orthology more info
located_in phagolysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phospholipase A2 group V

Names: calcium-dependent phospholipase A2; group V phospholipase A2; phosphatidylcholine 2-acylhydrolase 5; phospholipase A2, group 5

NP_058870.1

EC 3.1.1.4

XP_006239201.1

EC 3.1.1.4

XP_008762432.1

EC 3.1.1.4

XP_063143324.1

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429594.1 → NP_001416523.1 phospholipase A2 group V precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P51433, Q6DQ96

UniProtKB/TrEMBL

A6ITI7
NM_001429595.1 → NP_001416524.1 phospholipase A2 group V precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P51433, Q6DQ96

UniProtKB/TrEMBL

A6ITI7
NM_001429596.1 → NP_001416525.1 phospholipase A2 group V precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P51433, Q6DQ96

UniProtKB/TrEMBL

A6ITI7
NM_001429597.1 → NP_001416526.1 phospholipase A2 group V precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P51433, Q6DQ96

UniProtKB/TrEMBL

A6ITI7
NM_017174.3 → NP_058870.1 phospholipase A2 group V precursor

See identical proteins and their annotated locations for NP_058870.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P51433, Q6DQ96

UniProtKB/TrEMBL

A0A8I6A5J8, A6ITI7

Related

ENSRNOP00000107135.1, ENSRNOT00000125347.1

Conserved Domains (1) summary

smart00085
Location:22 → 137

PA2c; Phospholipase A2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

156324628..156393065 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287254.1 → XP_063143324.1 phospholipase A2 group V isoform X1

UniProtKB/Swiss-Prot

P51433, Q6DQ96

UniProtKB/TrEMBL

A6ITI7
XM_006239139.5 → XP_006239201.1 phospholipase A2 group V isoform X1

Conserved Domains (1) summary

smart00085
Location:22 → 137

PA2c; Phospholipase A2
XM_008764210.4 → XP_008762432.1 phospholipase A2 group V isoform X1

Conserved Domains (1) summary

smart00085
Location:22 → 137

PA2c; Phospholipase A2