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Rhod ras homolog family member D [ Rattus norvegicus (Norway rat) ]

Gene ID: 293660, updated on 2-Nov-2024

Summary

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Official Symbol
Rhodprovided by RGD
Official Full Name
ras homolog family member Dprovided by RGD
Primary source
RGD:1310985
See related
EnsemblRapid:ENSRNOG00000019220 AllianceGenome:RGD:1310985
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including focal adhesion assembly; lamellipodium assembly; and regulation of focal adhesion assembly. Predicted to act upstream of or within several processes, including actin filament polymerization; fibroblast growth factor receptor signaling pathway; and protein targeting. Predicted to be active in cell projection; cytosol; and plasma membrane. Orthologous to human RHOD (ras homolog family member D). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 101.1), Kidney (RPKM 69.2) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rhod in Genome Data Viewer
Location:
1q43
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (211138126..211153953, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201708699..201724405, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219668352..219682287, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor kinase 2 Neighboring gene lysine demethylase 2A Neighboring gene small nucleolar RNA SNORA32 Neighboring gene uncharacterized LOC134483956 Neighboring gene synaptotagmin 12 Neighboring gene solute carrier family 25 member 5, pseudogene 10 Neighboring gene similar to human chromosome 11 open reading frame 86

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Interaction of RhoD and ZIP kinase modulates actin filament assembly and focal adhesion dynamics. Nehru V, et al. Biochem Biophys Res Commun, 2013 Apr 5. PMID 23454120
  2. RhoD regulates cytoskeletal dynamics via the actin nucleation-promoting factor WASp homologue associated with actin Golgi membranes and microtubules. Gad AK, et al. Mol Biol Cell, 2012 Dec. PMID 23087206, Free PMC Article
  3. Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis. Karner CM, et al. Nat Genet, 2009 Jul. PMID 19543268, Free PMC Article
  4. The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements. Sandilands E, et al. J Cell Sci, 2007 Aug 1. PMID 17623777
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell projection assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein targeting ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to fibroblast growth factor ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell projection ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
rho-related GTP-binding protein RhoD
Names
ras homolog gene family, member D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106323.1 → NP_001099793.1  rho-related GTP-binding protein RhoD

    See identical proteins and their annotated locations for NP_001099793.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473953
    UniProtKB/TrEMBL
    A6HYX3, D4ADM8
    Related
    ENSRNOP00000026092.3, ENSRNOT00000026092.6
    Conserved Domains (1) summary
    cd04132
    Location:16 → 210
    Rho4_like; Ras homology family 4 (Rho4) of small guanosine triphosphatases (GTPases)-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    211138126..211153953 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108298.2 → XP_038964226.1  rho-related GTP-binding protein RhoD isoform X1

    Conserved Domains (1) summary
    cl38936
    Location:2 → 151
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_039108286.2 → XP_038964214.1  rho-related GTP-binding protein RhoD isoform X1

    Conserved Domains (1) summary
    cl38936
    Location:2 → 151
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_039108296.2 → XP_038964224.1  rho-related GTP-binding protein RhoD isoform X1

    Conserved Domains (1) summary
    cl38936
    Location:2 → 151
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version

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